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Note: reimbursed drug prices are in line with the regulations in force from July 1, 2018.
The preparation contains the substance:pantoprazole
The drug is available on prescription
What is Anesteloc?
A drug that inhibits the secretion of hydrochloric acid in the stomach, containing a proton pump inhibitor.
What does Anesteloc contain and how does it work?
The active substance of the preparation is Pantoprazole
, a benzimidazole derivative, a drug from the group of proton pump inhibitors (this group of drugs is sometimes indicated by the abbreviation IPP). This substance blocks the enzyme - a proton pump (ATP-aza K + / H +) in the Pariet
al cells of the gastric mucosa, thereby inhibiting the secretion of hydrochloric acid by these cells. In this way, the acidity (pH increases) of the gastric juice decreases. The degree of inhibition depends on the dose and applies to both basal and stimulated secretion of hydrochloric acid. In addition, the gastrin secretion is increased to a degree proportional to the reduction in the acidity of the gastric juice.
Pantoprazole is rapidly absorbed after oral administration, the maximum concentration in the blood is obtained approximately 2.5 hours after administration. The meal does not affect the maximum concentration or the bioavailability of the drug, it can only delay the onset of action. After 2 weeks of treatment with pantoprazole, the symptom relief is achieved in the majority of patients. Pantoprazole is mainly metabolised in the liver with the cytochrome P450 enzyme system, most metabolites excreted in the urine, partly also in the bile. Pantoprazole passes through the placenta and into the breast milk of women.
When should I use Anesteloc?
The preparation is indicated in adults and adolescents from 12 years of age:
· In reflux oesophagitis.
The preparation is indicated in adults:
· For eradicationHelicobacter pylori (H. pylori) in combination with appropriate antibiotics in patients with peptic ulcer diseaseH. pylori
· In peptic ulcer of the stomach and / or duodenum
· In Zollinger-Ellison syndrome and other conditions associated with excessive secretion of hydrochloric acid.
When not to use this preparation?
Unfortunately, even if there are indications to use the preparation, it can not always be used. You can not use the product if you are allergic (you are hypersensitive) to any of the ingredients or other benzimidazole-based medicines or to peanut or soya.
Take special care with Anesteloc?
Certain diseases and other circumstances may constitute a contraindication to use or indication to change the dosage of the preparation. In some situations it may be necessary to carry out specific check-ups.
Before starting treatment, the cancerous nature of the disease should be ruled out. The use of the preparation may mask the symptoms of cancer, including stomach cancer and delay the proper diagnosis. You should consult your doctor immediately if you have changed the nature of the symptoms or have disturbing symptoms, such as significant weight loss, recurrent vomiting, dysphagia, bloody vomiting, anemia, tar-like stools and if stomach ulceration is suspected or suspected.
If the symptoms persist despite the use of the preparation, a doctor should be consulted who may recommend further diagnostic tests.
If the treatment is long-lasting, especially if it lasts for more than a year, you should be under careful medical supervision.
If the doctor prescribes long-term use of the preparation, liver function should be monitored regularly, especially in patients with severe hepatic impairment. If there is an increase in liver enzymes, a doctor should be consulted because it is usually required to discontinue the preparation.
Parallel administration of the preparation with atazanavir is not recommended. However, if your doctor considers such combination treatment to be necessary, you must remain under careful medical supervision. Your doctor may recommend increasing the dose of antiviral medicines. Do not take a dose of pantoprazole greater than 20 mg per day.
Pantoprazole, like other drugs that reduce the secretion of hydrochloric acid, especially when used for a long time, may reduce the absorption of vitamin B12 (cyanocobalamin) and lead to clinical symptoms of its deficiency. Particular caution and regular check-ups are recommended in people who are deficient in vitamin B12 or with risk factors for its malabsorption.
The use of proton pump inhibitors may be associated with an increase in the number of naturally occurring bacteria in the upper gastrointestinal tract, as well as a slight increase in the risk of gastrointestinal infections by bacteria, such asSalmonella
If the preparation is used for at least 3 months or more, periodic monitoring of the Magnesium
concentration in blood is recommended. During long-term treatment, magnesium deficiency and severe hypomagnesaemia may occur. It may occur with symptoms such as fatigue, tetany, delirium, convulsions, dizziness and irregular heart rhythm, but sometimes these symptoms may remain latent. In case of hypomagnesaemia, it is necessary to supplement magnesium deficiency, and sometimes to discontinue using proton pump inhibitors. Using the product in parallel with some medicines (such as Digoxin
or diuretics) may further increase the risk of hypomagnesaemia; in this case, regular monitoring of the magnesium concentration in the blood is recommended.
Long-term use (more than a year) and / or high doses of pantoprazole or other proton pump inhibitors may be associated with an increased risk of bone fractures, especially in the elderly or with other risk factors. Patients at risk of osteoporosis should consult a physician and explain how to provide adequate supply of vitamin D and Calcium
Additional information about the other ingredients of the preparation:
· The product contains soya lecithin; Do not use in patients with hypersensitivity to peanut or soya.
Does this preparation affect the ability to drive vehicles?
In some people, the preparation may cause side effects such as blurred vision, dizziness and other symptoms that may impair psychophysical fitness. If these side effects occur, do not drive or operate machines or equipment.
Dosage of Anesteloc
The preparation is in the form of gastro-resistant tablets. It is intended for oral use. Use the product as directed by your doctor. Do not exceed the recommended doses because it will not increase the effectiveness of the drug and may harm your health and life. If you have any doubts regarding the use of the preparation, consult a physician.
Adults and adolescents after 12 years of age:
Reflux oesophagitis: usually 40 mg once daily, in some situations the doctor may recommend 80 mg daily. Treatment usually takes 4-8 weeks.
eradicationH. pylori40 mg twice daily in combination with the recommended antibiotics depending on the treatment regimen.The second tablet of the preparation should be taken 1 hour before the supper. Treatment lasts 7 days, if necessary up to 14 days. The doctor may then prescribe taking pantoprazole to completely cure the peptic ulcer, recommending a dosage as for the treatment of gastric and duodenal ulcer.
Peptic ulcer: 40 mg daily, if necessary 80 mg daily. Treatment usually takes 4-8 weeks.
Duodenal ulcer: 40 mg daily, 80 mg daily if needed. Treatment usually takes 2-4 weeks.
Zollinger and Ellison syndrome and other conditions associated with excessive secretion of hydrochloric acid: initially 80 mg once daily, then the dose is determined individually based on the results of gastric acid secretion tests, if necessary, a short-term dose increase to more than 160 mg per day . If doses are higher than 80 mg daily, they should be taken in two divided doses. The doctor will determine the duration of treatment.
Due to the lack of sufficient clinical data, it is not recommended for use in children under 12 years of age.
In patients with severe hepatic impairment, a dose of more than 20 mg per day should not be used. Do not use the product for eradicationH. pylori in patients with impaired renal function or moderate or severe hepatic impairment. There is no need to modify the dosage in the elderly or in patients with impaired renal function.
The preparation in the form of gastro-resistant tablets is intended for oral use. The tablets should be taken 1 hour before a meal, swallowed whole (do not chew, chew or crumble) with water.
Can Anesteloc be used during pregnancy and breastfeeding?
During pregnancy, do not use any medicine without consulting your doctor!
It is very important that before using any medicine during pregnancy or breastfeeding, consult a physician and explain beyond any doubt the potential risks and benefits associated with the use of the drug. If you are pregnant or plan to become pregnant, please inform the doctor prescribing the prescription for this medicine.
The preparation should not be used during pregnancy unless the doctor considers it absolutely necessary.
Do not use the product during breast-feeding.
Can I use other preparations in parallel?
Tell your doctor about all medicines you have recently taken, including those that are over the counter.
Pantoprazole reduces the secretion of hydrochloric acid in the stomach and thus reduces the acidity (increases the pH) of gastric juice. Therefore, pantoprazole may reduce the absorption of certain drugs, such as, for example, antifungal azole (ketoconazole, Itraconazole
, posaconazole) or erlotinib.
The parallel use of the preparation with atazanavir is not recommended. The preparation may significantly reduce the bioavailability and efficacy of atazanavir and other medicines used to treat HIV infection, the absorption of which depends on pH.
In parallel use of the preparation with anticoagulants, coumarin derivatives (warfarin, phenprocoumon), prothrombin time and INR are recommended at the beginning of treatment, after completion and if irregular use of pantoprazole.
Pantoprazole is metabolised in the liver with the cytochrome P450 enzyme system. To date, there has been no clinically significant interaction of pantoprazole with drugs that are metabolised by cytochrome P450.
There was no interaction of pantoprazole with antacids or with antibiotics such as Clarithromycin
What side effects can occur?
Like all medicines, Anesteloc 40 mg may cause side effects, although they will not occur in all patients who use this medicine. Remember that the expected benefits of using the drug are usually greater than the damage resulting from the occurrence of side effects.
Uncommon: sleep disturbances, headache and dizziness, nausea, diarrhea, vomiting, constipation, flatulence, abdominal fullness, dry mouth, epigastric pain and discomfort, increased liver enzymes, weakness, fatigue, malaise, fractures of the hip, wrist or spine bones, allergic reactions (pruritus, rash, eczema, eruptions).Rarely or very rarely: hematological disorders (leukopenia, thrombocytopenia), hypersensitivity and Anaphylactic reactions
(including urticaria, angioneurotic edema
, eg on the face, larynx, tongue, throat that may impede breathing, anaphylactic shock), increased lipid levels (triglycerides, cholesterol) , weight changes, depression, confusion, blurred vision, increased bilirubin, joint pain, myalgia, gynecomastia, increased body temperature, peripheral edema. In addition, hyponatremia, hypomagnesaemia, hallucinations, confusion, damage to liver cells leading to jaundice sometimes with hepatic failure, interstitial nephritis, hypersensitivity to light and severe skin reactions, including Stevens and Johnson syndrome, toxic epidermal necrolysis, may occur with unknown frequency. erythema multiforme.
Other preparations on the Polish market containing pantoprazole
Anesteloc Max (enteric-coated tablets)
Contix (enteric-coated tablets)
Contix ZRD (enteric-coated tablets)
Contracid (enteric-coated tablets)
Controloc (powder for solution for injection)
Controloc 20 (enteric-coated tablets)
Controloc 40 (enteric-coated tablets)
Controloc Control (enteric-coated tablets)
Gastrostad (enteric-coated tablets)
Gerdin (enteric-coated tablets)
Gerdin Max (gastro-resistant tablets)
IPP (powder for solution for injection)
IPP 20 (enteric-coated tablets)
IPP 40 (enteric-coated tablets)
Noacid (enteric-coated tablets)
Nolpaza 20 mg (enteric-coated tablets)
Nolpaza 40 mg (enteric-coated tablets)
Nolpaza Control (coated tablets)
Ozzion (enteric-coated tablets)
Pamyl 20 mg (enteric-coated tablets)
Pamyl 40 mg (enteric-coated tablets)
Panprazox (enteric-coated tablets)
Panrazol (enteric-coated tablets)
Pantogen 40 mg (enteric-coated tablets)
Pantopraz 20 mg (enteric-coated tablets)
Pantopraz 40 mg (enteric-coated tablets)
Pantopraz Bio (enteric-coated tablets)
Pantoprazole Krka (enteric-coated tablets)
Pantoprazole Teva (enteric-coated tablets)
Pantamrazole Vitama (enteric-coated tablets)
Pantoprazole Bluefish (enteric-coated tablets)
Pantoprazole Genoptim (enteric-coated tablets)
Pantoprazole Genoptim SPH (enteric-coated tablets)
Pantoprazole Mercapharm (enteric-coated tablets)
Panzol (enteric-coated tablets)
Panzol Pro (enteric-coated tablets)
Prazopant (powder for solution for injection)
Ranloc (enteric-coated tablets)
Ranloc Med (enteric-coated tablets)
Xotepic (enteric-coated tablets)