|The name of the preparation
||Character; dose; package
||Price after refund
||In which pharmacy?
Note: reimbursed drug prices are in line with the regulations in force from July 1, 2018.
The drug is available without a prescription
What is Aleve?
It is a preparation with general action containing a non-steroidal anti-inflammatory drug.
What does Aleve contain and how does it work?
The active substance is Naproxen
, a non-steroidal anti-inflammatory drug (NSAID) from the group of propionic acid derivatives (a naphthalene derivative). It has strong anti-inflammatory, analgesic and antipyretic effects. Naproxen counteracts the synthesis of prostaglandins, substances that play a significant role in the development of inflammation. The effect of naproxen is to inhibit the activity of cyclooxygenases (both COX-1 and COX-2). These enzymes take part in the reactions leading to the formation of prostaglandins from the lipids of cell membranes. Naproxen reduces the symptoms of inflammatory response (swelling, increased body temperature, pain, stiffness of the joints). The product is used in the treatment of inflammatory and pain conditions of rheumatic and non-rheumatic origin. It does not have antimicrobial activity. It also has an anti-platelet aggregation effect. The product contains naproxen in the form of sodium salt, which ensures faster absorption of the active substance and a faster start of analgesia. The analgesic effect occurs after 20 minutes, and the maximum concentration in the blood is usually obtained within 1 hour after administration. Naproxen sodium is almost completely absorbed from the gastrointestinal tract. The naproxen penetrates slowly into the joint cavities (stationary naproxen concentration in the synovial fluid is obtained after about 7 days of application). Naproxen passes through the placenta and into the breast milk of women.
When to use Aleve?
The product is indicated for the treatment of low or moderate pain, such as: headache, toothache, muscle pain, joint pain, back pain, dysmenorrhea, cold and fever pain.
When not to use this preparation?
Unfortunately, even if there are indications to use the preparation, it can not always be used. You can not use the preparation if you are allergic (you are hypersensitive) to any of the ingredients.
Contraindication to the preparation is allergic to Acetylsalicylic acid
(colloquially called sometimes Aspirin
) or other non-steroidal anti-inflammatory drugs. Allergy to these drugs may be manifested as an attack of asthma, urticaria or acute rhinitis.
The use of the preparation is contraindicated in people:
with active or past gastric and / or duodenal ulcers, bleeding or perforation, including NSAIDs
(2 or more confirmed ulcerations or bleeding episodes)
with severe kidney, liver or heart failure
with an increased risk of bleeding (haemorrhagic diathesis)
in women in the third trimester of pregnancy.
Do not use in breast-feeding women.
Do not use in children and adolescents up to 16 years of age.
When should you exercise extreme caution when using Aleve?
Certain diseases and other circumstances may constitute a contraindication to use or indication to change the dosage of the preparation.In some situations it may be necessary to carry out specific check-ups.
Use of the product at the lowest effective dose over the shortest possible period reduces the risk of side effects.
Special care and close medical supervision is required when using the preparation in elderly patients who are at increased risk of serious side effects.
It must not be used in conjunction with other naproxen-containing medicines, including naproxen sodium. Do not use the preparation with other NSAIDs, including selective COX-2 inhibitors (increased risk of serious side effects).
The use of non-steroidal anti-inflammatory drugs is associated with the risk of gastrointestinal haemorrhage, ulceration or perforation, which may be the cause of death and may not be preceded by warning signs. These symptoms can occur at any time during treatment, also in people without previous gastrointestinal disorders. These complications are particularly dangerous in the elderly. Always tell your doctor immediately if you have any unusual symptoms on the part of the digestive tract (especially bleeding). If there is bleeding from the gastrointestinal tract, immediate discontinuation of the preparation is necessary.
In patients with previous gastrointestinal diseases, the use of the preparation is possible only under strict medical supervision. In these patients, it is necessary to use the lowest effective doses. High doses and advanced age increase the risk of Gastrointestinal bleeding
in these patients. Take care and consult a doctor if you are taking other medicines at the same time increasing the risk of gastrointestinal side effects, including peptic ulceration or bleeding (eg corticosteroid
s with a general effect, anticoagulants, eg Warfarin
, platelet aggregation inhibitors, including even small doses of acetylsalicylic acid [colloquially called aspirin], drugs from the group of selective serotonin reuptake inhibitors). In the above cases, the doctor may sometimes recommend the use of protective drugs (eg misoprostol, proton pump inhibitors).
The preparation may mask the symptoms of infection. If you suspect an infection, consult your doctor, as appropriate treatment may be necessary. The preparation does not have an antimicrobial effect.
Special care should be taken in people:
· With a history of a digestive tract, including chronic inflammatory bowel diseases such as ulcerative colitis, Leśniowski's disease and Crohn's disease (risk of exacerbation)
· With active or past bronchial asthma, with allergic seasonal rhinitis, with polyps or chronic respiratory infections and in people allergic to any allergens (risk of developing bronchoconstriction causing difficulty in breathing and / or angioneurotic edema
that may impede breathing and be a threat life, it is necessary to provide the possibility of quick access to medical help)
· With blood clotting disorders or using anticoagulants (increased risk of bleeding, naproxen inhibits platelet aggregation and prolongs bleeding time)
· Hypertension, congestive heart failure, fluid retention, edema (use of NSAIDs may cause fluid retention and edema)
· With hepatic impairment, liver cirrhosis (the lowest effective dose should be used)
· With impaired renal function (risk of further deterioration of their activities, regular monitoring of renal function is recommended)
· With systemic lupus erythematosus and mixed connective tissue disease (increased risk of developing sterile meningitis)
· Using other medications, especially analgesics, steroids or diuretics
· In the elderly (increased risk of side effects, be especially careful and use the lowest effective dose for the shortest possible time, long-term use only under strict medical supervision).
If you suspect or have been diagnosed with any of the above conditions, consult a physician before using the preparation.
Prolonged use of naproxen at high doses may increase the risk of heart attack or stroke.
Special care and close medical supervision is required when using the product in hypertensive patients with congestive heart failure, fluid retention and edema, ischemic heart disease, peripheral artery disease or cerebrovascular disease, and in patients with risk factors for systemic diseases cardiovascular (diabetes, smoking, hyperlipidemia). If you belong to any of the above groups, consult a physician before using the preparation.
The preparation, like other non-steroidal anti-inflammatory drugs, may cause severe skin reactions, sometimes leading to death, such as Stevens and Johnson syndrome, toxic epidermal necrolysis, exfoliative dermatitis. These reactions are very rare and most often appear in the first month of application. In the event of the first symptoms of skin lesions (rash, mucosal lesions) or any symptoms of hypersensitivity, the preparation should be discontinued immediately and a physician should be consulted.
The preparation, like other non-steroidal anti-inflammatory drugs, can rarely cause hypersensitivity reactions, including angioedema, severe Anaphylactic reactions
that can be life-threatening.
The preparation may cause visual disturbances or other eye discomfort, the occurrence of which requires consultation with an ophthalmologist.
The use of the preparation may cause fertility problems in women and is not recommended in women who are planning to become pregnant. This effect is transient and disappears after treatment.
Additional information about the other ingredients of the preparation:
one tablet contains 20 mg of sodium; which should be taken into account for those who are on a low sodium diet.
Does this preparation affect the ability to drive vehicles?
In some people, the preparation may cause side effects affecting psychophysical fitness, such as blurred vision, drowsiness, dizziness, insomnia or other disorders of the central nervous system, which may impair the ability to drive vehicles and operate machines / machines. Exercise caution and refrain from activities requiring psychophysical fitness in the event of the above mentioned side effects.
Dosage of Aleve
The preparation is in the form of coated tablets. It is intended for oral use. Use the preparation as recommended. Do not exceed the recommended doses because it will not increase the effectiveness of the drug and may harm your health and life. If you have any doubts regarding the use of the preparation, consult a physician.
Adults: 220 mg every 8-12 hours until symptoms subside; in some people, the initial dose of 440 mg and then 220 mg after 12 hours may cause an increase in analgesia.
Do not use a dose greater than 660 mg a day.
You should not use the preparation for more than 10 days for the treatment of pain or for more than 3 days for the treatment of fever without consulting a doctor.
Do not use in children and adolescents up to 16 years of age.
If you have kidney or liver problems, your doctor may need to adjust your dose accordingly. The preparation is contraindicated if the creatinine clearance is less than 30 ml / min.
The preparation in the form of coated tablets is intended for oral use. The tablets can be taken with or without food, swallowed whole (do not chew or break), with a glass of water.
Can Aleve be used during pregnancy and breastfeeding?
During pregnancy, do not use any medicine without consulting your doctor!
It is very important that before using any medicine during pregnancy or breastfeeding, consult a physician and explain beyond any doubt the potential risks and benefits associated with the use of the drug. If you are pregnant or planning to become pregnant, consult your doctor before using the product (see the warnings in the section "Take special care with the preparation?").
The use of the preparation is contraindicated in women in the third trimester of pregnancy due to the risk of premature closure of the ductus arteriosus and suppression of uterine contraction. Do not use the preparation in the first and second trimester of pregnancy. The use of the preparation in the I and II trimesters of pregnancy is allowed only at the express request of the doctor and under his supervision, in cases when, after considering the ratio of expected benefits for the mother to possible risk to the fetus, he considers the use of the preparation absolutely necessary. Only a doctor can assess the benefit / risk ratio in your case.
Do not use in breast-feeding women.
Can I use other preparations in parallel?
Tell your doctor about all medicines you have recently taken, including those that are over the counter.
The use of antacids or cholestyramine may delay the absorption of naproxen.
Caution should be exercised when using naproxen with:
anticoagulants (eg warfarin, acenocoumarol, Heparin
) and drugs that inhibit platelet aggregation (possible increase in their effect, increase the risk of haemorrhage, the patient should remain under close medical supervision)
diuretics, e.g. Furosemide
(possible reduction of their effectiveness)
potassium-sparing diuretics (the risk of hyperkalemia)
antihypertensive agents, including angiotensin-converting enzyme inhibitors or angiotensin-blockers and beta-blockers (possible reduction in their efficacy, increased risk of renal damaging effects)
methotrexate and lithium (possible increase in plasma concentrations of both lithium and Methotrexate
and intensification of their toxic effects)
probenecid (severity and prolonged naproxen time)
cardiac glycosides, e.g. Digoxin
(the risk of increasing heart failure and increasing the concentration of cardiac glycosides in the blood)
cyclosporine and tacrolimus (increased risk of kidney damage)
zidovudine (prolonged bleeding time)
Hydantoin derivatives or sulphonamides (risk of increased activity)
acetylsalicylic acid or other non-steroidal anti-inflammatory drugs (increased risk of side effects, especially gastrointestinal bleeding; acetylsalicylic acid reduces the effect of naproxen)
quinolone antibiotics (increased risk of seizures)
corticosteroids or serotonin reuptake inhibitors (increased risk of side effects, especially gastrointestinal bleeding)
Impact on the results of laboratory tests:
It is recommended to stop taking naproxen for 48 hours before assessing adrenal function.
What side effects can occur?
Like all medicines, Aleve can cause side effects, although they will not occur in all patients who use this medicine. Remember that the expected benefits of using the drug are usually greater than the damage resulting from the occurrence of side effects.
Common or uncommon: indigestion, heartburn, abdominal pain, nausea, diarrhea, constipation, vomiting, headache and dizziness, drowsiness, insomnia, drowsiness, rash, urticaria, pruritus. Other side effects are rare or very rare and include: bleeding from the gastrointestinal tract, tar-like stools, bloody vomiting, gastric ulcer and / or duodenal ulcers with perforation, colitis, exacerbation of colitis, exacerbation of Leśniowski and Crohn's disease, inflammation of the mucous membrane of the cavity oral, esophagitis, acute pancreatitis, liver dysfunction, hepatitis (also fatal cases), jaundice, renal dysfunction, renal failure, renal papillary necrosis, haematuria
, proteinuria, interstitial nephritis, nephrotic syndrome, hyperkalemia, increase in creatinine in the blood, edema, hypertension, heart failure, palpitations, hematological disorders (haemolytic and aplastic anemia, agranulocytosis, leukopenia, thrombocytopenia, prolonged bleeding time if symptoms such as: sore throat, flu-like symptoms, superficial mouth ulcers, fatigue, nosebleeds, bruising, ecchymosis or purpura should be consulted doctor immediately, because they may be the first symptoms of hematological disorders), vasculitis, asthma, pulmonary edema , eosinophilic pneumonia, nervous system disorders (seizures, disturbances in the ability to concentrate, aseptic meningitis
, depression, paresthesia), visual disturbances, Corn
eal opacity, optic neuritis, optic nerve edema, tinnitus, impaired hearing.Hypersensitivity reactions (rash, urticaria, pruritus, photosensitivity) and anaphylactic reactions, including life-threatening anaphylactic shock (sudden decrease in blood pressure, arrhythmia), angioneurotic edema (swelling of the face, larynx, tongue, throat that may impede breathing), exacerbation of asthma, bronchospasm and severe skin reactions: toxic epidermal necrolysis, Stevens and Johnson syndrome, exfoliative dermatitis, erythema multiforme, purpura, haemorrhagic diathesis, porphyria. Prolonged use of naproxen at high doses may increase the risk of heart attack or stroke.
Other preparations on the Polish market containing naproxen (naproxen sodium)
Anapran (coated tablets)
Anapran neo (coated tablets)
Nalgesin (coated tablets)
Nalgesin Forte (coated tablets)
Nalgesin Mini (coated tablets)
Naxii (coated tablets)