► Adeksa (acarbose) - Practical Medicine

Adeksa (acarbose) - tablets

The name of the preparation Character; dose; package Manufacturer Price 100% Price after refund In which pharmacy?
Adeks tablets; 100 mg; 30 tabl. Polfarmex 14.29 4.29
Adeks tablets; 50 mg; 30 tabl. Polfarmex 7.55 2.55

Note: reimbursed drug prices are in line with the regulations in force from July 1, 2018.

The preparation contains the substance:acarbose

The drug is available on prescription

What is Adeksa?

Oral anti-diabetic drug. A medicine that reduces blood Glucose (a hypoglycaemic agent); it inhibits alpha-glucosidase activity and slows digestion of complex carbohydrates.

What does Adeksa contain and how does it work?

The active substance is acarbose, an oral antidiabetic medicine. Acarbose is used to reduce the level of glucose in the blood in the course of type 2 diabetes (previously the term "non-insulin dependent diabetes" was used). Acarbose only works locally in the intestine, where it inhibits the activity of alpha-glucosidases, enzymes involved in the digestion of complex carbohydrates. Glucose particles are released during digestion with these enzymes. Inhibition of alpha-glucosidase activity therefore leads to a decrease in glucose release in the intestine and limits postprandial increase in blood glucose (the main stimulus for insulin release). The daily fluctuations in blood glucose are reduced. During treatment, there is a significant reduction in fasting glucose and glycated hemoglobin. The effect of acarbose is the most effective if it is taken at the beginning of a meal. Taking acarbose 30 minutes before a meal or 15 minutes after starting a meal significantly reduces its effectiveness.

When to use Adeksa?

The preparation is indicated for the treatment of type 2 diabetes, especially in obese patients, in which the use of non-pharmacological methods (diet and exercise) is insufficient.

When not to use this preparation?

Unfortunately, even if there are indications to use the preparation, it can not always be used. You can not use the preparation if you are allergic (you are hypersensitive) to any of the ingredients.
The preparation can not be used in the case of:
· Chronic bowel diseases associated with digestion and absorption disorders
Conditions that may deteriorate as a result of increased gas accumulation in the gut (such as, for example, Roemheld's syndrome, large hernia, intestinal obstruction , intestinal ulceration)
· Severe renal failure (creatinine clearance less than 25 ml / min).
The preparation is contraindicated in pregnant women and women during breastfeeding.
It is not recommended for use in children and adolescents up to 18 years of age.

Take special care with Adeksa?

Certain diseases and other circumstances may constitute a contraindication to use or indication to change the dosage of the preparation. In certain situations, it may be necessary to carry out specific check-ups.
After starting treatment, for 6-12 months, liver enzymes should be monitored; rarely the use of the preparation may be associated with asymptomatic increase of their activity. These changes usually disappear after discontinuation of the preparation.
The safety and efficacy of the preparation in children and adolescents up to 18 years have not been established and therefore its use is not recommended in this age group.
It should be remembered that proper diet and regular physical activity have a significant impact on blood glucose control and treatment effectiveness. During the treatment period, it is essential to follow the recommended diabetic diet.
Do not stop taking your regular use yourself as this may result in increased blood glucose and loss of glycemic control.
It should be noted that the medicine is used in a book that is diabetic.
The preparation does not cause hypoglycaemia, but caution should be used if it is used in combination with insulin or other antidiabetic agents (eg sulphonylureas or Metformin ). If hypoglycaemia occurs during combination therapy, a doctor should be consulted as the dosage of antidiabetic medicinal products may need to be adjusted. If an acute hypoglycaemia occurs, the patient should take glucose to achieve rapid normalization of blood glucose.

Does this preparation affect the ability to drive vehicles?
If the preparation is used as monotherapy, it does not cause hypoglycaemia and therefore does not affect the ability to drive vehicles and operate machines / machines.
However, if the preparation is used in combination with other antidiabetic medicines (eg sulphonylureas, insulin, metformin) there is a risk of hypoglycaemia. In the case of hypoglycaemia, psychophysical fitness, including the speed of reaction, may be impaired. This can be a hazard when driving or operating equipment / machines.

Dosage of Adeksa

The preparation is in the form of tablets for oral use. Do not exceed the recommended doses because it will not increase the effectiveness of the drug and may harm your health and life. If you have any doubts regarding the use of the preparation, consult a physician.
The doctor will individually adjust the dosage. The tablets should be swallowed whole (without chewing) with a small amount of liquid. Take it immediately before or at the beginning of the meal.
Initially 50 mg once daily (dinner) for 3 days, then 50 mg 2 times a day (lunch and dinner) for the next 3 days, then 50 mg 3 times a day for 7 days, in the following days the dose should be further increased gradually according to the doctor's instructions; usually 50 mg (breakfast), 50 mg (lunch) and 100 mg (dinner) for 3 days, followed by 50 mg (breakfast), 100 mg (lunch) and 100 mg (dinner) for the next 3 days, so that from 4 .-8. weekly use 100 mg 3 times a day. In some cases, if necessary, the doctor may further increase the dose to 200 mg 3 times a day. The dose can be increased after 4-8 weeks if there is insufficient response to treatment. If the annoying side effects persist despite adherence to the diabetic diet, do not increase the dose, and in some cases you need to reduce the dose (as recommended by your doctor).
There is no need to modify the dosage in the elderly or with liver failure.
The safety and efficacy of the preparation in children and adolescents up to 18 years have not been established and therefore its use is not recommended in this age group.

Can I use Adeksa during pregnancy and breastfeeding?

During pregnancy, do not use any medicine without consulting your doctor!
It is very important that before using any medicine during pregnancy or breastfeeding, consult a physician and explain beyond any doubt the potential risks and benefits associated with the use of the drug. If you are pregnant or plan to become pregnant, please inform the doctor prescribing the prescription for this medicine.
The use of the preparation during pregnancy is contraindicated. If during pregnancy, a woman becomes pregnant or plans to become pregnant, please consult a doctor as soon as possible because it is recommended to change the treatment for insulin therapy as soon as possible.
The use of the preparation during breast-feeding is contraindicated.

Can I use other preparations in parallel?

Tell your doctor about all medicines you have recently taken, including those that are over the counter. During the period of application, taking any other medicines can only take place with the consent of the doctor or on his recommendation.
If the preparation is used in combination with insulin or other antidiabetes medicines (eg sulphonylureas or metformin), hypoglycaemia may occur.If hypoglycaemia occurs during combination therapy, a doctor should be consulted as the dosage of antidiabetic medicinal products may need to be adjusted. Acute hypoglycaemia may occur occasionally. In this situation, the patient should take glucose to quickly normalize the blood glucose (glucose is the most appropriate, because the use of the preparation causes a slower decomposition of sucrose to glucose and fructose).
Avoid consumption of sucrose; eating sucrose can often cause gastrointestinal discomfort, including diarrhea associated with increased fermentation of carbohydrates in the large intestine.
The preparation may alter the bioavailability of Digoxin ; it may be necessary to adjust the doctor's dosage of digoxin.
During the treatment period, the simultaneous use of cholestyramine, adsorption preparations and digestive enzymes should be avoided as they may reduce the effect of the preparation.
Orally administered neomycin may additionally exacerbate postprandial glucose lowering and gastrointestinal side effects. In the event of a significant increase in adverse reactions, your doctor may recommend reducing the doses used.
No interaction was observed between the preparation and dimethicone / simeticone.

What side effects can occur?

Like all medicines, Adeksa can cause side effects, although they will not occur in all patients who use this medicine. Remember that the expected benefits of using the drug are usually greater than the damage resulting from the occurrence of side effects.
Bloating is very common; often: diarrhea, abdominal pain and other gastrointestinal disorders; uncommon: nausea, vomiting, indigestion, increased liver enzymes. Failure to comply with a diabetic diet, i.e. eating foods containing sucrose, may exacerbate these symptoms. If, despite adherence to the diet, bothersome side effects persist, it is usually necessary to temporarily or permanently reduce the dose (any dosage changes are possible only on the order of a physician). Rare edema and jaundice are rare. Hypoglycaemia may occur in combination with other antidiabetic agents. There may also be other side effects for which their incidence has not been established, including: thrombocytopenia, allergic reactions (rash, erythema, urticaria), intestinal obstruction or near intestinal obstruction, intestinal malfunction, hepatitis, liver dysfunction, damage to the intestines liver, isolated cases of fulminant hepatic failure leading to death (in this case the causal relationship with the use of the preparation has not been elucidated).

Other preparations on the Polish market containing acarbose

Glucobay (tablets)