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Note: reimbursed drug prices are in line with the regulations in force from July 1, 2018.
The preparation contains the substance:alprazolam
The drug is available on prescription
What is Alprox?
Anxiolytic medicine from the group of benzodiazepine derivatives.
What does Alprox contain and how does it work?
The active substance is alprazolam. Alprazolam is a benzodiazepine derivative with short to medium duration. It exerts a dose-dependent inhibitory effect on all levels of the central nervous system, ranging from slight sedation, through sleep, to coma. It stimulates and facilitates the inhibitory action of gamma-aminobutyric acid (GABA), which is the main inhibitor of neurotransmission in the brain and is responsible for the pre- and post-synaptic inhibition in all parts of the central nervous system. In comparison to other benzodiazepines, alprazolam exerts a stronger anxiolytic and anxiolytic effect, while maintaining the effect of reducing muscle tone, anticonvulsant and sedative-hypnotic.
When to use Alprox?
The preparation is indicated for the treatment of:
· Anxiety disorders with anxiety attacks (panic disorder)
· Symptomatic anxiety.
It is recommended to use the preparation only in those cases where the symptoms are severe, disturb the proper functioning or are very troublesome for the patient.
When not to use this preparation?
Unfortunately, even if there are indications to use the preparation, it can not always be used. You can not use the product if you are allergic (you are hypersensitive) to any of the ingredients or other benzodiazepines.
Contraindications to the use of the preparation are also:
· Muscle tiredness (myasthenia gravis)
· Severe respiratory failure
· Periodic severe sleep apnea
· Severe liver failure.
The preparation should not be used in children and adolescents up to 18 years of age.
Take special care with Alprox?
Certain diseases and other circumstances may constitute a contraindication to use or indication to change the dosage of the preparation. In some situations it may be necessary to carry out specific check-ups.
During the several weeks of the use of drugs in this group, the phenomenon of tolerance may occur; then you need ever higher doses of the preparation to achieve the same therapeutic effect.
During treatment, there may be a development of addiction or psychological or physical dependence on the drug. Special risk groups include people with a tendency to abuse drugs (including drugs) and alcohol.
Special care is required when treating people with depression and suicidal tendencies. Any disturbing change in behavior, noticed by the patient or those around him, should be notified immediately to the doctor.
Mania and hypomania have been reported in people with depression treated with this preparation.
Due to the possible occurrence of so-called "withdrawal syndrome" (headache, muscle pain, strong anxiety, tension, anxiety, confusion and irritability, and in severe cases also: feelings of unreality, depersonalization, hyperaesthesia, tingling and burning sensations in the extremities, hypersensitivity to light, noise and physical contact, hallucinations or fits), do not interrupt the use of the preparation. Your doctor will advise you to gradually reduce your dose over a period of time that is long enough for you.
Drugs from this group may cause amnesia. It occurs most often within a few hours after taking the preparation.In order to reduce the risk, the patient should make sure that he will have the possibility of uninterrupted sleep lasting 7 to 8 hours.
In the case of symptoms such as:
please contact your doctor who will probably recommend stopping the use of the preparation will inform you about the further procedure.
The preparation is not intended for the basic treatment of psychosis. It should not be used as monotherapy for anxiety disorders associated with depression due to the increased risk of suicide in the patient. Use in people with severe depression or people with suicidal tendencies requires special attention from the doctor.
Special care should be taken in people:
· Currently or in the past, abusing alcohol or medication
· With impaired liver or kidney function
· With angle-closure glaucoma.
Persons with chronic respiratory failure, as well as elderly and weakened persons should receive lower doses of the preparation.
Do not use the preparation in children and adolescents up to 18 years of age.
Information on additional components of the preparation:
The preparation contains lactose, people with hereditary galactose intolerance, primary lactase deficiency or malabsorption of Glucose
-galactose should not use it.
Does this preparation affect the ability to drive vehicles?
Due to the calming effect, alprazolam may, especially at the beginning of treatment and during the dose escalation, have an adverse effect on activities requiring increased alertness, coordination of movements and rapid response (eg when driving vehicles, operating machines, working at heights, etc.). Be careful!
Dosage of Alprox
The preparation is in the form of tablets. It is intended for oral use. Do not exceed the recommended doses because it will not increase the effectiveness of the drug and may harm your health and life. If you have any doubts regarding the use of the preparation, consult a physician.
Anxiety disorder with anxiety attacks.
Adults. Initially, 0.5-1 mg 1 / day in the evening, then the doctor may decide to increase the dose, not faster than 1 mg every 3-4 days. In the elderly, people with liver or kidney failure and sensitive to treatment initially 0.25 mg 2-3x / day are used; the maximum maintenance dose is 6 mg / day in 3-4 divided doses, in rare cases 10 mg / day, and in the elderly 4.5 mg / day.
Symptomatic treatment of anxiety.
Adults. Initially 0.25-0.5 mg 3x / day, then the dose should be adjusted individually; the maintenance dose is 0.5-3 mg / day in divided doses. In the elderly, people with liver or kidney failure and sensitive to treatment initially 0.25 mg 2-3x / day are used.
The drug is intended for use only in case of severe symptoms, disturbing normal activity. The duration of treatment should not exceed 8-12 weeks. The dose should be reduced gradually, not faster than by 0.5 mg every 3 days, in some people more slowly.
Can Alprox be used during pregnancy and breastfeeding?
During pregnancy, do not use any medicine without consulting your doctor!
It is very important to consult a physician before taking any medicine during pregnancy (and also during breastfeeding) and to explain beyond any doubt the potential risks and benefits of using the medicine. If you are pregnant or plan to become pregnant, please inform the doctor prescribing the prescription for this medicine.
During pregnancy, the use of the drug is acceptable, only if in the doctor's opinion it is absolutely necessary.
Do not use the product during breast-feeding.
Can I use other preparations in parallel?
Tell your doctor about all medicines you have recently taken, including those that are over the counter.
Caution should be used in parallel:
Drugs that depress the central nervous system, such as: painkillers, antiepileptics, neuroleptics, hypnotics, sedatives, antidepressants, antihistamines with a sedative effect, because their actions may be intensified; your doctor will probably recommend a reduction in the dose of one or both medicines used simultaneously
· Opioid analgesics; there is a danger of euphoria, which can increase psychological dependence
· Clozapine; there is an increased risk of respiratory arrest and cardiac arrest
· Muscle relaxants; there may be an increase in their activity and increased exposure to falls
· Substances that inhibit specific liver enzymes (especially CYP3A4
cytochrome P450 isoenzyme); they can increase the concentration of alprazolam and increase its effect
HIV protease inhibitors (e.g., ritonavir); your doctor will probably recommend a dose adjustment or discontinuation of alprazolam
· Nefazodone, fluvoxamine and cimetidine; your doctor may decide to reduce your doses accordingly
, propoxyphene, oral contraceptives, sertraline, diltiazem or macrolide antibiotics such as Erythromycin
· Imipramine and desipramine; their plasma concentration may increase
; there may be an increase in its concentration in the blood.
Co-administration of alprazolam, ketoconazole, Itraconazole
and other azole antifungals is not recommended.
You should not drink alcohol during treatment.
What side effects can occur?
Like all medicines, Alprox can also cause side effects, although they will not occur in all patients who use this medicine. Remember that the expected benefits of using the drug are usually greater than the damage resulting from the occurrence of side effects.
Adverse reactions usually occur at the beginning of treatment and disappear as it continues.
Very often may occur: sedation, drowsiness.
Common: appetite suppression, depression, confusion, akathisia, ataxia, coordination disorders, memory disorders, speech disorders, concentration difficulties, headache, dizziness, dizziness, blurred vision, tachycardia, palpitations, nasal obstruction, gastrointestinal (constipation, diarrhea, dry mouth, increased salivation, difficulty swallowing), allergic dermatitis, fatigue, asthenia, irritability.
Uncommon: hyperprolactinemia, anorexia, psychiatric and paradoxical disorders, insomnia, abnormal thinking, nervousness, agitation, changes of sex drive, amnesia, dystonia, tremor, blurred vision, double vision, increased intraocular pressure, vomiting, jaundice, liver dysfunction, pruritus, musculoskeletal weakness, urinary incontinence or retention, menstrual disorders, sexual dysfunction, weight changes.
Rarely may occur: increased appetite, addiction, numbness, decreased alertness, hypotension, skin disorders.
In addition, vegetative symptoms, hepatitis, vascular edema, peripheral edema may occur with an unknown frequency.
Other preparations on the Polish market containing alprazolam
Neurol 0.25 (tablets)
Neurol 1.0 (tablets)
Neurol SR 0.5 (prolonged release tablets)
Xanax SR (prolonged release tablets)
Zomiren SR (modified release tablets)