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► Naxii (naproxen (naproxen sodium)) - Practical Medicine

Naxii (naproxen (naproxen sodium)) - coated tablets

The name of the preparation Character; dose; package Manufacturer Price 100% Price after refund In which pharmacy?
Naxii coated tablets; 220 mg; 10 tables US Pharmacia 7.48 Check
Naxii coated tablets; 220 mg; 20 tables US Pharmacia 11.99

Note: reimbursed drug prices are in line with the regulations in force from July 1, 2018.

The preparation contains the substance:naproxen (naproxen sodium)

The drug is available without a prescription

What is Naxii?

It is a preparation with general action containing a non-steroidal anti-inflammatory drug.

What does it contain and how does Naxia work?

The active substance is Naproxen , a non-steroidal anti-inflammatory drug (NSAID) from the group of propionic acid derivatives (a naphthalene derivative). It has strong anti-inflammatory, analgesic and antipyretic effects. Naproxen counteracts the synthesis of prostaglandins, substances that play a significant role in the development of inflammation. The effect of naproxen is to inhibit the activity of cyclooxygenases (both COX-1 and COX-2). These enzymes take part in the reactions leading to the formation of prostaglandins from the lipids of cell membranes. Naproxen reduces the symptoms of inflammatory response (swelling, increased body temperature, pain, stiffness of the joints). The product is used in the treatment of inflammatory and pain conditions of rheumatic and non-rheumatic origin. It does not have antimicrobial activity. It also has an anti-platelet aggregation effect. The product contains naproxen in the form of sodium salt, which ensures faster absorption of the active substance and a faster start of analgesia. The analgesic effect occurs after 20 minutes, and the maximum concentration in the blood is usually obtained within 1 hour after administration. Naproxen sodium is almost completely absorbed from the gastrointestinal tract. The naproxen penetrates slowly into the joint cavities (stationary naproxen concentration in the synovial fluid is obtained after about 7 days of application). Naproxen passes through the placenta and into the breast milk of women.

When to use Naxii?

The preparation is indicated for symptomatic treatment:
· Low to moderate pain associated with colds, headaches, teeth, muscles, rheumatic pains, back pains
· Painful menstruation
· Fever.

When not to use this preparation?

Unfortunately, even if there are indications to use the preparation, it can not always be used. You can not use the preparation if you are allergic (you are hypersensitive) to any of the ingredients.
Contraindication to the preparation is allergic to Acetylsalicylic acid (colloquially called sometimes Aspirin ) or other non-steroidal anti-inflammatory drugs. Allergy to these drugs may be manifested as an attack of asthma, urticaria or acute rhinitis.
The use of the preparation is contraindicated in people:
with active or past peptic ulcer of the stomach and / or duodenum, bleeding or perforation, including NSAIDs
with severe heart failure
using other painkillers, including Ibuprofen , acetylsalicylic acid, Paracetamol , other medicines containing naproxen
and
in women in the third trimester of pregnancy.
Do not use in breast-feeding women.
Do not use the preparation in people prone to allergic reactions.
Do not use children under 12 without consulting a doctor.

Take special care with Naxii?

Certain diseases and other circumstances may constitute a contraindication to use or indication to change the dosage of the preparation.In some situations it may be necessary to carry out specific check-ups.
Use of the product at the lowest effective dose over the shortest possible period reduces the risk of side effects.
It must not be used in conjunction with other naproxen-containing medicines, including naproxenone or other non-steroidal anti-inflammatory drugs, including selective COX-2 inhibitors (increased risk of serious side effects).
Prolonged use of naproxen at high doses may increase the risk of heart attack or stroke.
Consumption of alcohol during the use of the preparation may cause gastric bleeding.
The use of non-steroidal anti-inflammatory drugs is associated with the risk of gastrointestinal haemorrhage, ulceration or perforation, which may be the cause of death and may not be preceded by warning signs. These symptoms can occur at any time during treatment, also in people without previous gastrointestinal disorders. These complications are particularly dangerous in the elderly. Always tell your doctor immediately if you have any unusual symptoms on the part of the digestive tract (especially bleeding). If there is bleeding from the gastrointestinal tract, immediate discontinuation of the preparation is necessary.
In the case of long-term treatment, regular monitoring of renal function is recommended, especially in people with heart failure, functional disorders and / or cirrhosis. Special care and medical supervision is required when using the preparation in the elderly, in whom the risk of serious side effects is increased. The lowest effective doses should always be used in the elderly.
Special care should be taken in people:
· With a history of a digestive tract, including chronic inflammatory bowel diseases such as ulcerative colitis, Leśniowski's disease and Crohn's disease (risk of exacerbation)
· With active or past bronchial asthma, respiratory diseases with bronchospasm and allergic diseases (risk of bronchospasm causing difficulty in breathing and / or angioneurotic edema that may impede breathing and be life-threatening, it is necessary to provide quick access to help medical)
· With blood clotting disorders or using anticoagulants (increased risk of bleeding, naproxen inhibits platelet aggregation and prolongs bleeding time)
· In the elderly (increased risk of side effects, be especially careful and use the lowest effective dose for the shortest possible time, long-term use only under strict medical supervision).
If you suspect or have been diagnosed with any of the above conditions, consult a physician before using the preparation.
The preparation may mask the symptoms of infection. If you suspect an infection, consult your doctor, as appropriate treatment may be necessary. The preparation does not have an antimicrobial effect.
The preparation, like other non-steroidal anti-inflammatory drugs, can rarely cause hypersensitivity reactions and severe Anaphylactic reactions that can be life-threatening. If hypersensitivity symptoms such as urticaria, dyspnoea, angioneurotic edema or side effects occur such as nausea, vomiting or abdominal pain, stop using the product immediately.
The use of the preparation may cause fertility problems in women and is not recommended in women who are planning to become pregnant.
Additional information about the other ingredients of the preparation:
the preparation contains lactose; people with galactose intolerance, lactase deficiency or malabsorption of Glucose -galactose should not use this preparation.

Does this preparation affect the ability to drive vehicles?
In some people, the preparation may cause side effects affecting psychophysical fitness, such as blurred vision, drowsiness, dizziness or other disorders of the central nervous system, which may impair the speed of reaction and the ability to drive vehicles and operate equipment / machines. If the above-mentioned symptoms occur, refrain from performing activities requiring psychophysical fitness.

Dosage of Naxia

The preparation is in the form of coated tablets. It is intended for oral use. Use the preparation as recommended. Do not exceed the recommended doses because it will not increase the effectiveness of the drug and may harm your health and life. If you have any doubts regarding the use of the preparation, consult a physician.
Adults: 220 mg (1 tablet) every 8-12 hours or 440 mg (2 tablets) as the starting dose, then 220 mg (1 tablet) every 12 hours. Do not use a dose greater than 660 mg (3 tablets) per day.
Elderly patients should not take a dose greater than 220 mg (1 tablet) every 12 hours.
The preparation should not be used in children under 12 without consulting a doctor.

Can I use Naxii during pregnancy and breastfeeding?

During pregnancy, do not use any medicine without consulting your doctor!
It is very important that before using any medicine during pregnancy or breastfeeding, consult a physician and explain beyond any doubt the potential risks and benefits associated with the use of the drug. If you are pregnant or planning to become pregnant, consult your doctor before using the product (see the warnings in the section "Take special care with the preparation?").
The use of the preparation is contraindicated in women in the third trimester of pregnancy due to the risk of premature closure of the ductus arteriosus and suppression of uterine contraction. Do not use the preparation in the first and second trimester of pregnancy. The use of the preparation in the I and II trimesters of pregnancy is allowed only at the express request of the doctor and under his supervision, in cases when, after considering the ratio of expected benefits for the mother to possible risk to the fetus, he considers the use of the preparation absolutely necessary. Only a doctor can assess the benefit / risk ratio in your case.
Do not use in breast-feeding women.

Can I use other preparations in parallel?

Tell your doctor about all medicines you have recently taken, including those that are over the counter.
It must not be used in conjunction with other naproxen-containing medicines, including naproxenone or other NSAIDs, including selective COX-2 inhibitors (increased risk of serious side effects).
Caution should be exercised when using naproxen with:
anticoagulants (eg Warfarin , acenocoumarol, Heparin ) and drugs that inhibit platelet aggregation (possible increase in their effect, increase the risk of haemorrhage, the patient should remain under close medical supervision)
diuretics, e.g. Furosemide (possible reduction of their effectiveness)
antihypertensive agents, including angiotensin-converting enzyme inhibitors and beta-blockers (possible reduction in their effectiveness, increased risk of damaging kidneys)
methotrexate and lithium (possible increase in plasma concentrations of both lithium and Methotrexate and intensification of their toxic effects)
probenecid and sulfinpyrazone (severity and prolonged naproxen time)
phenytoin or sulfonamides (the risk of their effect)
corticosteroids or serotonin reuptake inhibitors (increased risk of side effects, especially Gastrointestinal bleeding )
sulphonylurea derivatives.

What side effects can occur?

Like all medicines, Naxii can also cause side effects, although it will not occur in all patients who use this medicine. Remember that the expected benefits of using the drug are usually greater than the damage resulting from the occurrence of side effects.
The most common are gastrointestinal side effects: heartburn, abdominal pain, nausea, constipation, less frequently diarrhea, dyspepsia , and oral mucositis. Rare bleeding from the gastrointestinal tract, tar-like stools, bloody vomiting, gastric ulcer and / or duodenal ulcers with perforation, colitis, exacerbation of colitis, exacerbation of Leśniowski and Crohn's disease, hepatitis (also fatal cases), jaundice. Possible headaches and dizziness, insomnia, drowsiness, feeling of bewilderment, muscle weakness, rarely depression, malaise, seizures, impaired concentration, aseptic meningitis . Visual disturbances, Corn eal opacities, optic neuritis, optic disc edema, tinnitus, and hearing disorders may occur.Other side effects include: dyspnea, edema, palpitations, hypertension, heart failure, kidney problems, renal failure, renal papillary necrosis, haematuria , proteinuria, interstitial nephritis, nephrotic syndrome, hyperkalemia, increased blood creatinine, hematologic disorders (haemolytic and aplastic anemia, agranulocytosis, leukopenia, thrombocytopenia, prolonged bleeding time if symptoms such as fever, sore throat, flu-like symptoms, superficial oral ulceration, fatigue, epistaxis, bruising, ecchymosis or purpura occur consult a doctor, because they may be the first symptoms of hematological disorders), vasculitis, asthma, pulmonary edema, eosinophilic pneumonia, increased thirst, menstrual disorders. Hypersensitivity reactions (rash, urticaria, pruritus, photosensitivity) and anaphylactic reactions, including life-threatening anaphylactic shock (sudden decrease in blood pressure, arrhythmia), angioneurotic edema (swelling of the face, larynx, tongue, throat that may impede breathing), exacerbation of asthma, bronchospasm and severe skin reactions: toxic epidermal necrolysis, Stevens and Johnson syndrome, exfoliative dermatitis, erythema multiforme, purpura, haemorrhagic diathesis, porphyria. Prolonged use of naproxen at high doses may increase the risk of heart attack or stroke.

Other preparations on the Polish market containing naproxen (naproxen sodium)

Aleve (coated tablets)
Anapran (coated tablets)
Anapran neo (coated tablets)
Nalgesin (coated tablets)
Nalgesin Forte (coated tablets)
Nalgesin Mini (coated tablets)