|The name of the preparation
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Note: reimbursed drug prices are in line with the regulations in force from July 1, 2018.
The preparation contains the substance:olanzapine
The drug is available on prescription
What is Anzorin?
A drug from the group of neuroleptics used in the treatment of certain mental disorders, containing olanzapine
What does Anzorin contain and how does it work?
The detailed mechanism of action of olanzapine is not known, it is probably associated with the blocking of serotonin-dependent receptors (5-HT2A / 2C, 5-HT3, 5-HT6), and Dopamine
(D1, D2, D3, D4, D5) as well as cholinergic muscarinic (M1-M5), 1-adrenergic and histamine H1 receptors. It has a greater impact on 5-HT2A receptors than on D2 receptors. It also has anti-mania effect and stabilizes the mood. It has a beneficial effect on both the negative and positive symptoms of schizophrenia.
When to use Anzorin?
The preparation is indicated in:
· Treatment of schizophrenia
· Long-term maintenance treatment in people who have a good response to initial treatment
· Treatment of moderately severe and severe manic episodes
· Preventing the recurrence of bipolar disorder in people who have responded well to olanzapine in the treatment of mania.
When not to use this preparation?
Unfortunately, even if there are indications to use the preparation, it can not always be used. You must not use the product if you are allergic (you are hypersensitive) to any of the ingredients or if you have been diagnosed with glaucoma with an occlusive angle of glaucoma.
When should you take extra care with Anzorin?
Certain diseases and other circumstances may constitute a contraindication to use or indication to change the dosage of the preparation. In some situations it may be necessary to carry out specific check-ups.
When using antipsychotics, improvement of the clinical condition may occur after a few days or weeks. During this time, the patient should be under the special care of a physician.
The preparation is not indicated for the treatment of patients with symptoms of psychosis and / or behavioral disorders due to dementia due to increased mortality and the risk of adverse cerebrovascular events. Risk factors predisposing to increased mortality are: age over 65 years, dysphagia, sedation, malnutrition and dehydration, lung diseases or concomitant use of benzodiazepines.
Olanzapine should not be used to treat psychosis caused by the intake of dopamine agonists in people with Parkinson's disease (symptoms may worsen and hallucinations occur).
If a significant, unexplained increase in body temperature occurs without treatment during treatment, immediately consult a physician, as this may be a sign of a so-called "neuroleptic malignant syndrome" that is dangerous to your health and life. Other symptoms are:
· Increase in muscle tone
·\tdisturbances of consciousness
· Signs of instability of the autonomic nervous system (irregular heart rate or fluctuations in blood pressure, tachycardia, profuse sweating, arrhythmias);
· In addition, there may be an increase in creatinine phosphokinase and myoglobinuria due to muscle breakdown (rhabdomyolysis) and acute renal failure
The doctor will probably recommend discontinuation of the preparation and will inform you about further treatment.
In some patients, orthostatic hypotension may occur at the beginning of treatment in combination with tachycardia, dizziness and syncope. The risk of these phenomena can be reduced by reducing the initial doses of the preparation by the physician.
Particular care should be taken in people with known cardiovascular disease (myocardial infarction, ischemia, heart failure
or conductive disorders), in people with cerebrovascular disease and in conditions that may predispose patients to hypotension (dehydration, small vascular bed filling, use of antihypertensive drugs). Periodic blood pressure measurements are recommended in patients over 65 years of age.
In the following cases, the patient should be under the supervision of a physician (who will commission appropriate additional examinations):
· If you have diabetes or are at high risk of developing this disease (you should be able to control your weight and your blood Glucose
· If you have lipid disturbances or are in a group of people predisposed to such disorders
· If you suffer from prostatic hypertrophy, paralytic ileus and similar diseases that may be exacerbated by the anticholinergic properties of olanzapine
· If you have a small number of leukocytes and / or neutrophils, if you are taking medicines that can cause neutropenia, have been found to have a depressed activity and / or bone marrow toxicity to a medication, suffer from myelosuppression caused by co-existing disease, radiation or Chemotherapy
and if it was diagnosed with hypereosinophilia or myeloproliferative disease.
The preparation should be used with caution in people:
· Using other medicines that may cause QT prolongation in the elderly with congenital long QT syndrome, congestive heart failure, cardiac hypertrophy, reduced potassium or Magnesium
in the blood
· With convulsive seizures or with a low convulsive threshold, e.g. in Alzheimer's disease; lowering of the seizure threshold is more likely in patients over 65 years of age
· With liver problems and those using medicines with potentially hepatotoxic properties; (transient increase in aminotransferase levels has been observed, especially at the beginning of treatment, periodic monitoring of ALT and AST is recommended, if you suspect hepatitis, the doctor will probably recommend discontinuation of the preparation)
· With risk factors for venous thromboembolism
· In parallel using drugs that act on the central nervous system or alcohol.
Due to the risk of withdrawal syndrome (sweating, insomnia, tremor, anxiety, nausea or vomiting), you should not stop your treatment suddenly.
If you experience symptoms of tardive dyskinesia (involuntary movements of masseter muscles, tongue, upper limbs and torso), you should immediately consult a physician.
The effect of a combination of factors such as age, smoking, sex, can lead to significant changes in the concentration of the preparation in the blood. In young smoking men, it can be three times higher than in older, non-smoking women. Modification of the dosage by the physician may be necessary for people exposed to the combination of factors that have an effect on the release of the metabolism of the preparation.
Do not use the preparation in children and adolescents up to 18 years of age.
Information on additional components of the preparation:
The preparation contains aspartame, which is a source of phenylalanine, people with phenylketonuria should not use it.
Does this preparation affect the ability to drive vehicles?
The preparation may impair your ability to drive or use machines. Be careful when using it!
Dosage of Anzorin
The preparation is in the form of orodispersible tablets. It is intended for oral use. Use the preparation as recommended. Do not exceed the recommended doses because it will not increase the effectiveness of the drug and may harm your health and life. If you have any doubts regarding the use of the preparation, consult a physician.
Adults, regardless of meals; orodispersible tablets should be taken immediately after taking them out of the container, or dissolved in a glass of water or other suitable drink (orange or apple juice, milk, coffee) just before taking. Initially, usually 10 mg / day, and in the case of moderate and severe manic episodes 15 mg 1 × / day as monotherapy or 10 mg / day in combination therapy. Then the daily dose should be determined depending on the patient's clinical condition, usually in the range of 5-20 mg / day. Your doctor will advise you to increase the dose accordingly after assessing the clinical condition of the patient, no more frequently than every 24 hours.
In the elderly, a lower starting dose (5 mg / day) is not routinely recommended, however, it should be considered in patients over 65, if clinical data supports this.
In patients with impaired renal and / or hepatic function, and if more than one factor that can slow down metabolism (female gender, old age, non-tobacco use), consider a starting dose of 5 mg / day. In people with moderate hepatic impairment, initially 5 mg / day; the dose should be increased with extreme caution.
Can you use Anzorin during pregnancy and breastfeeding?
During pregnancy, do not use any medicine without consulting your doctor!
It is very important that before using any medicine during pregnancy or breastfeeding, consult a physician and explain beyond any doubt the potential risks and benefits associated with the use of the drug.
During pregnancy, the preparation can only be used if, in the doctor's opinion, the benefits for the mother outweigh the risks to the fetus.
You should not breast-feed while using the product.
Can I use other preparations in parallel?
Tell your doctor about all medicines you have recently taken, including those that are over the counter.
Some drugs and other substances that are metabolized by the same enzyme system may affect the concentration of olanzapine. Carbamazepine and smoking may cause a decrease in blood levels, fluvoxamine and Ciprofloxacin
may increase them. In some cases, it may be necessary to modify the dosage by the doctor.
Activated carbon reduces the bioavailability of olanzapine, these lei should be administered with a 2-hour break.
Caution should be exercised in patients who consume alcohol or use medications that may inhibit the activity of the central nervous system.
The parallel use of olanzapine and products administered to treat Parkinson's disease in patients with Parkinson's disease and dementia is not recommended.
Caution should be exercised when using olanzapine in parallel and medicines that prolong the QT interval.
What side effects can occur?
Like all medicines, Anzorin can cause side effects, although it will not occur in all patients using this product. Remember that the expected benefits of using the drug are usually greater than the damage resulting from the occurrence of side effects. If in doubt about any side effects, please consult your doctor.
Very common: drowsiness, weight gain, increased plasma prolactin levels.
Common: eosinophilia, increased cholesterol, glucose and / or triglycerides in the blood, glycosuria, increased appetite, dizziness, parkinsonism, akathisia, dyskinesia, orthostatic hypotension, mild, transient anticholinergic effects (dryness of the oral mucosa, fragrance), transient, asymptomatic elevation of hepatic transaminases, especially at the beginning of treatment, rash, erectile dysfunction, decreased libido in men and women, asthenia, fatigue, edema.
Uncommon: leukopenia, neutropenia, bradycardia, QT prolongation, thromboembolism (including pulmonary embolism and deep vein thrombosis), hypersensitivity to light, urinary incontinence, urinary retention, alopecia, amenorrhea, breast enlargement, milk production beyond breastfeeding, gynecomastia or breast enlargement in men, high creatinine phosphokinase, increased total bilirubin.
Moreover, with an undefined frequency, thrombocytopenia, allergic reaction, development or exacerbation of diabetes occasionally associated with ketoacidosis or coma may occur, including fatal cases, hypothermia, seizures (in predisposed individuals), neuroleptic malignant syndrome, dystonia (including eye rotation), tardive dyskinesia, withdrawal symptoms, ventricular tachycardia or ventricular fibrillation, sudden death, pancreatitis, hepatitis, transverse striated muscle disorder, bladder feeling, withdrawal syndrome in newborns, priapism (prolonged, painful erection without sexual arousal) ), increase in alkaline phosphatase.
Other preparations on the Polish market containing olanzapine
Egolanza (coated tablets)
Olanzapin Actavis (orodispersible tablets)
Olanzapine Mylan (orodispersible tablets)
Olanzapine STADA (coated tablets)
Olanzapine Apotex (coated tablets)
Olanzapine Apotex (orodispersible tablets)
Olanzapine Bluefish (orodispersible tablets)
Olanzapine Lekam (orodispersible tablets)
Olanzapine Mylan (coated tablets)
Olanzaran (orodispersible tablets)
Olanzin (coated tablets)
Olazax Disperzi (orodispersible tablets)
Olpinat (coated tablets)
Olzapin (coated tablets)
Synza 5 mg (tablets)
Synza 10 mg (tablets)
Zalasta (coated tablets)
Zalasta (disintegrating tablets in the mouth)
Zolafren (coated tablets)
Zolafren-Swift (orodispersible tablets)
Zolaxa (coated tablets)
Zolaxa Rapid (orodispersible tablets)
Zopridoxin (orodispersible tablets)
Zypadhera (powder and solvent for prolonged release suspension for injection)
Zyprexa (powder for solution for injection)