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Note: reimbursed drug prices are in line with the regulations in force from July 1, 2018.
The preparation contains the substance:valsartan
The drug is available on prescription
What is Avasart?
The drug from the group of angiotensin II receptor antagonists, which, like all preparations in this group, limits the action of angiotensin II, a substance that causes vasoconstriction and aldosterone-stimulating release.
What does Avasart contain and how does it work?
The active substance is valsartan belonging to a group of medicines called angiotensin II receptor antagonists or sartans. The common mechanism of action of drugs in this group is the blocking of angiotensin II receptors which prevents them from binding to angiotensin II and inhibits its action (drugs from this group are often indicated by the abbreviation ARB, which comes from the English nameAngiotensin II Receptor Blockers
). Agiotensin II plays an important role in the pathophysiology of hypertension. The effect of angiotensin II is vasoconstriction and the increase in the release of aldosterone, which leads to increased blood pressure. The effect of valsartan, like other sartans, effectively counteracts the effects of angiotensin II and leads to a decrease in blood pressure. Unlike drugs from the angiotensin-converting enzyme inhibitors, sartans do not exacerbate the effects of bradykinin-dependent, for example, cough. Sartans are used as medicines to lower blood pressure and to treat and prevent diseases of the cardiovascular system. In patients with heart failure
, they reduce vascular resistance, which improves hemodynamic conditions, increases exercise capacity and improves the clinical condition. They have a protective effect on the kidneys, slow down the rate of development associated with high blood pressure and diabetes renal dysfunction.
Valsartan lowers blood pressure without affecting the heart rate. Lowering blood pressure occurs within 2 hours after taking a single dose of valsartan (the maximum pressure drop occurs after 4-6 hours) and lasts for 24 hours. Full development of antihypertensive activity usually requires 2.-4. weeks of use and persists during long-term treatment.
When to use Avasart?
The preparation is indicated for the treatment of:
· Spontaneous hypertension
· In the treatment of symptomatic heart failure, if angiotensin converting enzyme inhibitors (ACE inhibitors) can not be used, or as a combination therapy with ACE inhibitors, if beta-blockers can not be used.
When not to use this preparation?
Unfortunately, even if there are indications to use the preparation, it can not always be used. You can not use the preparation if you are allergic (you are hypersensitive) to any of the ingredients.
Contraindications are contraindicated in people with severe hepatic impairment, cirrhosis or cholestasis
The preparation is contraindicated in the second and third trimester of pregnancy and during breastfeeding. It is not recommended during the first trimester of pregnancy.
Take special care with Avasart?
Certain diseases and other circumstances may constitute a contraindication to use or indication to change the dosage of the preparation. In some situations it may be necessary to carry out specific check-ups.
It is not recommended to use the preparation and medicines that increase the level of potassium in the blood (eg potassium sparing diuretics, potassium supplements, potassium chloride replacers, Heparin
, non-steroidal anti-inflammatory drugs, trimethoprim, immunosuppressive drugs such as cyclosporin or tacrolimus, etc.). at the risk of hyperkalemia (increased potassium in the blood). Hyperkalaemia may cause serious arrhythmias. Blood potassium levels should often be monitored.
Caution should be exercised because the preparation may cause symptomatic hypotension, especially in patients with circulating, dehydrated or sodium deficient circulating blood (eg, people who have previously received high doses of diuretics, low salt diets, diarrhea or vomiting). Before starting treatment, electrolyte deficits should be leveled and adequate hydration should be ensured. If necessary, your doctor will adjust the dosage of diuretics.
After the use of other preparations acting on the renin-angiotensin-aldosterone system in patients with bilateral renal artery stenosis or stenosis of the artery of the only active kidney there was an increase in urea and creatinine in the blood. The safety of valsartan in this group of patients has not been established. Caution and regular monitoring of renal function (creatinine and urea blood levels) should be undertaken.
There are insufficient data on the use of the preparation in patients after recent kidney transplantation.
It is not recommended to use the preparation in patients with primary hyperaldosteronism, because the effect of the preparation in this group of patients is not effective.
Caution should be exercised in the case of impaired left-ventricular blood flow (occurrence of aortic or mitral stenosis, hypertrophic cardiomyopathy).
No dose adjustment is necessary for adults with renal impairment, provided the creatinine clearance is greater than 10 ml / min. If the creatinine clearance is less than 10 ml / min or the patient undergoes hemodialysis, caution should be exercised because there is no clinical experience regarding the use of the product in this group of patients.
People should be treated with caution in patients with mild or moderate hepatic dysfunction without bile stasis. The preparation is contraindicated in the presence of severe hepatic impairment, liver cirrhosis or cholestasis (cholestasis).
In the presence of heart failure, the parallel use of preparations from three groups of drugs, i.e. ACE inhibitors, beta-blockers and valsartan, is not recommended, due to the increased risk of side effects while not providing clinically significant benefits. The evaluation of renal function is necessary before starting the use in this group of patients. Caution should be exercised, especially at the beginning of treatment. The use of the preparation may cause a decrease in blood pressure, but it is not usually necessary to stop using it because of persistent symptomatic hypotension.
In patients at higher risk of renal dysfunction, renal function depends on the activity of the renin-angiotensin-aldosterone system (e.g.in patients with severe congestive heart failure or with kidney disease) the use of ACE inhibitor drugs is associated with the risk of oliguria, increased urea and creatinine in the blood and rarely, acute renal failure
. Caution should be exercised and treatment should be under special medical supervision. It can not be ruled out that valsartan and other drugs that, like ACE inhibitors, act on the renin-angiotensin-aldosterone system can cause kidney problems.
Does this preparation affect the ability to drive vehicles?
No studies on the effects on the ability to drive and use machines / machines have been performed. However, it should be taken into account that the preparation may cause dizziness, fatigue or other symptoms that may impair psychophysical fitness and the ability to drive vehicles and operate machinery and equipment.
Dosage of Avasart
The preparation is in the form of coated tablets. It is intended for oral use. The tablets can be taken with or without water. Do not exceed the recommended doses because it will not increase the effectiveness of the drug and may harm your health and life. If you have any doubts regarding the use of the preparation, consult a physician.
Hypertension: starting dose of 80 mg once daily. The antihypertensive effect is noticeable within 2 weeks of use and the full antihypertensive effect is achieved after 4 weeks. If necessary, your doctor may increase the dose to 160 mg per day or up to a maximum dose of 320 mg per day. In addition, your doctor may prescribe hydrochlorothiazide (a diuretic) that enhances the antihypertensive effect of valsartan.
Heart failure: the starting dose is 40 mg 2 times a day and treatment can only be started under close medical supervision; then the doctor will increase the dose to 80 mg and 160 mg taken twice a day at intervals of at least two weeks. The maximum dose is 160 mg 2 times a day. If a diuretic is used in parallel, your doctor will consider reducing your dose. The preparation can be used in combination with medicines used to treat heart failure. Parallel reception of valsartan, ACE inhibitors and beta-blockers (triple combination) is not recommended. The kidneys should be monitored regularly.
Elderly patients do not need to adjust their dosage.
There is no need to adjust the dose in adults with renal impairment if creatinine clearance is greater than 10 ml / min.
In adults with mild or moderate hepatic impairment without bile stasis, doses higher than 80 mg per day should not be used. The preparation is contraindicated in the presence of severe hepatic impairment, liver cirrhosis or cholestasis (cholestasis).
Do not use the preparation in children and adolescents up to 18 years of age due to lack of sufficient clinical experience.
Can I use Avasart during pregnancy and breastfeeding?
During pregnancy, do not use any medicine without consulting your doctor!
It is very important that before using any medicine during pregnancy or breastfeeding, consult a physician and explain beyond any doubt the potential risks and benefits associated with the use of the drug. If you are pregnant or plan to become pregnant, please inform the doctor prescribing the prescription for this medicine.
The preparation should not be used during the first trimester of pregnancy. The use of the preparation in the second and third trimester of pregnancy is contraindicated. If a woman plans to become pregnant she should consult a doctor because it is recommended to change the way of antihypertensive treatment. If you suspect or confirm pregnancy during the period of taking the preparation, you should consult a doctor as soon as possible because immediate discontinuation of the preparation is required. Your doctor will prescribe other antihypertensive agents.
Do not use the product during breast-feeding.
Can I use other preparations in parallel?
Tell your doctor about all medicines you have recently taken, including those that are over the counter.
The preparation, like angiotensin-converting enzyme (ACE inhibitors), may increase the toxic effects of lithium salts. The simultaneous use of lithium is not recommended, and if necessary, combination therapy should be used with caution and control of the concentration of lithium in the blood.
Parallel use of drugs that affect the level of potassium in the blood (potassium salts, potassium supplements, potassium sparing diuretics, such as, for example, spironolactone, triamterene, amiloride, eplerenone, immunosuppressants, such as tacrolimus, cyclosporine, ACE inhibitors, angiotensin II receptor antagonists, trimethoprim, heparin, non-steroidal anti-inflammatory drugs) and potassium chloride substitutes may lead to increased levels of potassium in the blood (hyperkalemia). The parallel use of valsartan with the preparations mentioned above is not recommended. If it is necessary to use them, the doctor will recommend regular monitoring of potassium in the blood.
Non-steroidal anti-inflammatory drugs (eg Acetylsalicylic acid
, indomethacin) may reduce the antihypertensive effect of the preparation and cause renal dysfunction and increase in potassium in the blood. Adequate hydration and regular renal function should be ensured. Be careful.
There were no clinically significant interactions when the product was used in parallel with the following drugs: Furosemide
, cimetidine, Atenolol
, indometacin, hydrochlorothiazide, Amlodipine
What side effects can occur?
Like all medicines, Avasart can cause side effects, although they will not occur in all patients who use this medicine. Remember that the expected benefits of using the drug are usually greater than the damage resulting from the occurrence of side effects.
Frequent or not very common side effects include: dizziness, hypotension, including orthostatic hypotension (associated with a change in body position), weakness, fatigue, kidney problems, increased creatinine
and urea in the blood, acute renal failure, angioneurotic edema
(swelling of the face, lips, tongue, throat, larynx in sporadic cases that may cause narrowing of the airways, impede breathing and life-threatening), cough, nausea, diarrhea, abdominal pain, heart failure (in patients after myocardial infarction), fainting, headaches, increase in potassium in the blood (hyperkalemia). In addition, possible other side effects for which their incidence has not been determined: anemia, thrombocytopenia, hematocrit reduction, neutropenia, hypersensitivity, serum sickness, decreased sodium in the blood (hyponatraemia), increase in potassium in the blood, inflammation blood vessels, increased liver enzymes, increased bilirubin in the blood, muscle pain, rash, pruritus.
Other preparations on the Polish market containing valsartan
Apo-Valsart (coated tablets)
Awalone (coated tablets)
Axudan (coated tablets)
Bespres (coated tablets)
Diovan (coated tablets)
Ivisart (coated tablets)
Nortivan (coated tablets)
Nortivan Neo (coated tablets)
Tensart (coated tablets)
Valorion (coated tablets)
Valsacor 80 mg (coated tablets)
Valsacor 160 mg (coated tablets)
Valsacor 320 mg (coated tablets)
Valsargen (hard capsules)
Valsartan 123ratio (hard capsules)
Valsartan Aurobindo (coated tablets)
Valsartan Genoptim (coated tablets)
Valsotens (coated tablets)
Valtap (coated tablets)
Vanatex (coated tablets)
Valsartan KRKA (coated tablets)