|The name of the preparation||Character; dose; package||Manufacturer||Price 100%||Price after refund||In which pharmacy?|
|Aerius||oral solution; 0.5 mg / ml; 150 ml||Merck Sharp & Dohme||36.50|
|Aerius||oral solution; 0.5 mg / ml; 60 ml||Merck Sharp & Dohme||17.50||Check|
Note: reimbursed drug prices are in line with the regulations in force from July 1, 2018.
An antihistamine with antiallergic activity.
The active substance of the preparation is desloratadine, a second generation antihistamine (unlike first generation drugs, second generation antihistamines used at the recommended doses are practically free of sedation, because they do not affect the central nervous system). Desloratadine is the main active metabolite of Loratadin e. Desloratadine, like loratadine , is a histamine antagonist, selectively blocks peripheral histamine type 1 (H1) receptors. In this way, it circumferentially inhibits the action of histamine, a substance that causes allergic symptoms.In vitro desloratadine inhibits the release of cytokines by human mast cells and basophils. These mechanisms are probably responsible for reducing the allergic reaction. Relieves allergic symptoms such as sneezing, runny nose, swelling and itching of mucous membranes, tears and redness of the eyes, urticaria (relieves pruritus and reduces the number and size of urticaria changes).
Desloratadine is well absorbed after oral administration, the maximum concentration in blood is reached after about 3 hours. The enzyme responsible for the metabolism of desloratadine has not been known so far, so interaction with other drugs can not be ruled out. The effect of desloratadine persists for more than 24 hours.
The product is indicated for use in adults, adolescents and children after one year of age to relieve symptoms associated with:
• with allergic rhinitis
• with urticaria.
Unfortunately, even if there are indications to use the preparation, it can not always be used. You can not use the product if you are allergic (you are hypersensitive) to any of the ingredients or to loratadine.
It is not recommended for pregnant women or breast-feeding women.
Certain diseases and other circumstances may constitute a contraindication to use or indication to change the dosage of the preparation. In some situations it may be necessary to carry out specific check-ups.
It is not recommended for use in children up to 1 year of age due to the lack of data on the safety and efficacy of the preparation in this age group.
Before using the product in children under the age of 2, it is necessary to ensure that the rhinitis is allergic. In children up to two years of age, it is particularly difficult to distinguish the allergic form from other forms of rhinitis. Your doctor may recommend that you perform appropriate laboratory tests and skin tests.
In some people (approximately 6% of the Caucasian race), the metabolism of desloratadine is slowed down, resulting in a risk of increased exposure to the drug.
In case of suspected or confirmed kidney dysfunction, consult a doctor before using the product. Caution should be exercised in people with severe renal impairment.
Additional information about the other ingredients of the preparation:
• the preparation contains sorbitol; people with inherited disorders associated with fructose intolerance should not use the preparation.
Does this preparation affect the ability to drive vehicles?
In clinical trials, there was no reduction in psychomotor performance in people taking desloratadine. However, before driving or operating machinery / equipment, check the individual response to the medicine and be careful.
Very rarely, some people may experience side effects, such as drowsiness, which may impair your ability to drive or use machines / machines.
The preparation is in the form of an oral solution. A dosing syringe is included in the package. Take orally. Can be taken with or without food. Do not exceed the recommended doses because it will not increase the effectiveness of the drug and may harm your health and life. If you have any doubts regarding the use of the preparation, consult a physician.
Adults and children over 12 years: 5 mg (10 ml) once a day.
Children 6-12. 2.5 mg (5 ml) once a day.
Children 1-6. year of life: 1.25 mg (2.5 ml) once a day.
Do not use the preparation in children up to 1 year of age due to the lack of data on the safety and efficacy of the preparation in this age group.
In the case of severe renal failure, your doctor will adjust the dosage.
During pregnancy, do not use any medicine without consulting your doctor!
It is very important that before using any medicine during pregnancy or breastfeeding, consult a physician and explain beyond any doubt the potential risks and benefits associated with the use of the drug. If you are pregnant or plan to become pregnant, please inform the doctor prescribing the prescription for this medicine.
It is not recommended during pregnancy or during breastfeeding.
Tell your doctor about all medicines you have recently taken, including those that are over the counter.
Parallel administration of the preparation with ketoconazole or Erythromycin does not result in clinically significant interactions.
In clinical trials, desloratadine did not potentiate the effects of alcohol and psychomotor disorders caused by alcohol. However, alcohol intolerance and alcohol intoxication have been reported after the medicine has been placed on the market.
The enzyme responsible for the metabolism of desloratadine has not yet been identified, so interaction with other drugs can not be ruled out.
Like all medicines, Aerius can also cause side effects, although it will not occur in all patients who use this medicine. Remember that the expected benefits of using the drug are usually greater than the damage resulting from the occurrence of side effects.
Fatigue, dry mouth, headache and dizziness, drowsiness, insomnia, psychomotor agitation, convulsions, hallucinations, increased heart rate (tachycardia), palpitations, QT prolongation in ECG, arrhythmia, nausea, vomiting may occur , abdominal pain, diarrhea, indigestion, abnormal liver function (including increased liver enzymes, increased bilirubin, hepatitis), muscle pain, hypersensitivity reactions (rash, urticaria, pruritus) and Anaphylactic reactions (including severe reactions that may be a threat life including throat edema, larynx, bronchospasm, dyspnea, hypotension, anaphylactic shock). In clinical trials in children 6-23. one month of life the most common side effects were diarrhea, fever and insomnia.
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