|The name of the preparation||Character; dose; package||Manufacturer||Price 100%||Price after refund||In which pharmacy?|
|Asmenol||coated tablets; 10 mg; 28 tabl.||Polpharma||22.31||
Note: reimbursed drug prices are in line with the regulations in force from July 1, 2018.
An oral anti-asthmatic drug with anti-inflammatory and anti-bronchial spasms. Recommended additionally or as an alternative to other anti-inflammatory drugs (corticosteroids) in the long-term treatment of asthma. The therapeutic effect is already present after the first dose and lasts for 24 hours.
The active substance is montelukast . It belongs to a group of anti-inflammatory drugs called leukotriene receptor antagonists. The mechanism of action of montelukast is the inhibition of the activation of leukotriene receptors located in the airways. Activation of these receptors by leukotrienes, which are mediators of inflammation, leads to increased vascular permeability in the bronchial mucosa, edema, mucus secretion and bronchoconstriction. Leukotrienes are released in the respiratory tract of mast cells (eosinophils) and eosinophils (granulocytes). The preparation inhibits the effects of leukotrienes. It alleviates inflammatory symptoms such as swelling and irritation, inhibits the secretion of excessive amounts of dense mucus, stops the accumulation of inflammation cells (including eosinophils), and also has a bronchodilator effect and improves lung ventilation. It counteracts bronchoconstriction caused by physical effort.
The preparation is used:
• helpful in the treatment of asthma in patients with mild or moderate chronic asthma, in whom the effects of treatment with inhaled corticosteroid s and short-acting beta-agonists which are used are unsatisfactory;
• in the prevention of asthma, in which the spasm of the bronchi is caused mainly by physical effort.
In patients from the age of 2 to 14 years, chewable tablets may also be used instead of low doses of inhaled corticosteroids in those patients with mild asthma who have recently experienced severe asthma attacks oral corticosteroids, as well as in patients who are unable to use inhaled corticosteroids.
In patients over 15 years of age, in which the preparation is used to treat bronchial asthma, it can also relieve the symptoms of seasonal allergic rhinitis.
Unfortunately, even if there are indications to use the preparation, it can not always be used. You can not use the product if you are allergic (you are hypersensitive) to any of the ingredients.
Never use Asmenol to stop an acute asthma attack! In the case of acute asthma attack, use an inhaled medicine from a group of beta-agonists with a rapid onset of action (eg Salbutamol ). Always carry a inhaler with a fast-acting bronchodilator. If you notice that you must use a larger than usual dose of inhaled beta-agonist, you should consult your doctor as soon as possible.
The preparation does not replace inhalation or oral corticosteroids.When starting treatment with the product, do not stop taking or reduce doses of inhaled corticosteroids or tablets.
Rarely, some people taking anti-asthmatics, including montelukast, may experience eosinophilia (an increase in the number of eosinophils, or eosinophils in the blood), sometimes with clinical manifestations of vasculitis, which corr esponds to the diagnosis of Churg and Strauss syndrome (also known as allergic granulomatous vasculitis). This syndrome is often treated with systemic corticosteroids, and its occurrence is usually, but not always, associated with dose reduction or discontinuation of oral corticosteroid therapy. It can not be ruled out or confirmed that the use of montelukast is associated with the occurrence of the Churg and Strauss syndrome. Exercise caution and if eosinophilia, rash, inflammatory infiltration in the skin, worsening of respiratory symptoms, cardiac dysfunction and / or neuropathy (pain, numbness, tingling, burning or weakness in the extremities) should be consulted with a physician . The doctor will carry out thorough diagnostic tests and will verify further treatment.
People with asthma who are hypersensitive to Acetylsalicylic acid should continue to avoid acetylsalicylic acid and other non-steroidal anti-inflammatory drugs despite Montelukast treatment.
The safety and efficacy of the preparation in children under the age of 2 have not been established.
Additional information about the other ingredients of the preparation:
- chewing and chewing tablets 4 and 5 mg contain aspartame, a source of phenylalanine (1 tablet contains 4.8 and 6 mg aspartame, respectively) which may be harmful for people with phenylketonuria;
- 10 mg film-coated tablets contain lactose (1 tablet contains 100 mg lactose); people with galactose intolerance, lactase deficiency or malabsorption of Glucose -galactose should not use this preparation.
Important information about the use of the preparation.
After oral administration, the drug is rapidly absorbed. The preparation works already on the first day after the start of its use. Treatment should be continued both at periods of lower intensity of symptoms and during periods of asthma exacerbation. Other medicines containing the same active substance, i.e. montelukast, should not be used in parallel.
Montelukast is not recommended for use as monotherapy (as the only drug) for moderate persistent asthma. In mild-intensity asthma, the doctor may consider the use of Asmenol chewable and chewable tablets at 4 or 5 mg instead of small doses of inhaled corticosteroids in children from 2 to 14 years of age only when severe seizures have not occurred recently. asths requiring the use of oral corticosteroids, and in people who can not use inhaled corticosteroids. It is important to remember about regular follow-up visits to determine if an adequate level of control of asthma symptoms has been achieved.
If the preparation is used to prevent asthma in people whose bronchoconstriction is caused mainly by physical effort, a doctor should be consulted 2-4 weeks after the start of treatment. If the doctor considers the result of treatment unsatisfactory, he may recommend changing the drug or the use of additional drugs (eg inhaled corticosteroids).
Do not substitute inhaled corticosteroids with 10 mg film-coated tablets. The preparation in this dose can be used as an auxiliary medicine in people who do not provide adequate asthma control if other medicines such as inhaled corticosteroids are used. Asmenol 10 mg may also be included in addition to treatment in people who are not adequately controlled by bronchial asthma with short-acting adjunctive beta-agonists.
If the preparation has been added to treatment with inhaled corticosteroids, sudden inhaled corticosteroids should not be discontinued and replaced with Asmenol.
- To always buy your prescription in time and buy a new one before you use up the previous one.
- Always have a quick-acting inhaler with a bronchodilator.
Does this preparation affect the ability to drive vehicles?
Montelukast is not expected to affect the ability to drive, however, if such side effects like drowsiness or dizziness occur, the ability to drive or use machines may be impaired.
Use the product as directed by your doctor. Do not exceed the recommended doses because it will not increase the effectiveness of the drug and may harm your health and life.There is no need to change the dosage in the elderly, with renal insufficiency or with mild to moderate hepatic impairment. There are no data on the use of the preparation in people with severe hepatic impairment. If you have any doubts regarding the use of the preparation, consult a physician. Unless your doctor tells you otherwise, the usual doses are:
Adults and adolescents over 15 years of age.
Asthma or asthma and concurrent seasonal allergic rhinitis: 1 10 mg tablet once a day, administered in the evening. The preparation can be taken regardless of meals.
Children 6 to 14 years old.
1 tablet 5 mg once daily administered in the evening. The preparation should be taken 1 hour before meals or 2 hours after a meal.
Children 2 to 5 years old.
1 tablet 4 mg once daily administered in the evening. The preparation should be taken 1 hour before meals or 2 hours after a meal.
There are no data on the efficacy and safety of the preparation in children up to the age of 2 years.
During pregnancy, do not use any medicine without consulting your doctor!
It is very important that before using any medicine during pregnancy or breastfeeding, consult a physician and explain beyond any doubt the potential risks and benefits associated with the use of the drug. If you are pregnant or plan to become pregnant, please inform the doctor prescribing the prescription for this medicine.
Data regarding the safety of the preparation during pregnancy are limited. The preparation can be used during pregnancy only if the doctor considers it absolutely necessary. Only a doctor can assess the risk-benefit ratio in your case.
It is not known if the product is excreted in human milk. The preparation can be used during breastfeeding only if the doctor considers it absolutely necessary.
Tell your doctor about all medicines you have recently taken, including those that are over the counter.
Caution should be exercised, especially in children, during the parallel use of the preparation and drugs such as phenytoin, phenobarbital and rifampicin (as well as other drugs metabolized with the use of the cytochrome P 450 3A4 isoenzyme).
Montelukast can be used in parallel with other medicines commonly used for the prevention and long-term treatment of asthma. The preparation in therapeutic doses does not have a clinically relevant effect on the pharmacokinetics of the following drugs: theophylline, prednisone, Prednisolone , oral contraceptives (ethinyl estradiol and norethindrone), terfenadine, Digoxin and Warfarin . Montelukast is not considered to significantly alter the metabolism of drugs such as Paclitaxel , rosiglitazone and repaglinide.
Like all medicines, Asmenol can cause side effects, although they will not occur in all patients who use this medicine. Remember that the expected benefits of using the drug are usually greater than the damage resulting from the occurrence of side effects.
After applying the preparation may occur: headaches, drowsiness, abdominal pain, increased thirst. Rarely side effects or side effects that have not been identified include dizziness, sleep disturbances, weakness, fatigue, malaise, paresthesia, irritability, hallucinations, agitation, aggressive behavior, anxiety, convulsions, palpitations, diarrhea, dryness oral mucus, indigestion, nausea, vomiting, joint and muscle pain, muscle cramps, increased bleeding tendency, hypersensitivity reactions (rash, pruritus, urticaria), eosinophil infiltrates in the liver. Some rare but serious side effects include hypersensitivity reactions of the anaphylactic type (severe urticaria, angioneurotic edema of the mouth, tongue, throat that may impede breathing and / or swallowing and others). If you notice the appearance of anaphylactic reaction symptoms, you should stop using the preparation immediately and seek medical help immediately. Rarely may increase serum aminotranferase (ALT, AST), cholestatic hepatitis.Rarely, some people using the product may experience systemic eosinophilia, sometimes with clinical signs of vasculitis, which corresponds to the diagnosis of Churg and Strauss syndrome (see the comments in the paragraph above, entitled 'Take special care with this medicine?').
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