|The name of the preparation
||Character; dose; package
||Price after refund
||In which pharmacy?
||nasal spray, suspension;
27.5 μg / dose;
||GlaxoSmithKline - United Kingdom
Note: reimbursed drug prices are in line with the regulations in force from July 1, 2018.
The drug is available on prescription
What is Avamys?
A nasal spray containing a corticosteroid. The preparation with local anti-inflammatory and antiallergic.
What does Avamys contain and how does it work?
The active substance is fluticasone. Fluticasone is a synthetic corticosteroid with a strong anti-inflammatory and antiallergic effect. When applied topically to the nose, it inhibits the inflammatory process, reduces swelling and irritation. Relieves allergic symptoms such as sneezing, runny nose, swelling and itching of nasal mucous membranes, nasal congestion, as well as pruritus, burning, tearing and redness of the eyes. The main mechanism of action of fluticasone in the target cell is to inhibit or stimulate the expression of genes whose protein products influence the inflammatory process. Corticosteroids may also work in a different way without affecting gene expression. However, the mechanism of such their operation is still little known. The beginning of the preparation's action occurs about 8 hours after application, and further improvement is observed within the next few days. Effectiveness is maintained within 24 hours between successive administrations. Intranasal administration of the recommended dose of 110 μg once a day usually does not cause significant systemic effects, and the concentration of fluticasone in the blood in most patients is unambiguous (smaller than the threshold of measurability).
When should I use Avamys?
The preparation is indicated in adults, adolescents and children after the age of 6 in the treatment of the symptoms of allergic rhinitis.
When not to use this preparation?
Unfortunately, even if there are indications to use the preparation, it can not always be used. You can not use the preparation if you are allergic (you are hypersensitive) to any of the ingredients.
Do not use in children under 6 years of age.
Take special care with Avamys?
Certain diseases and other circumstances may constitute a contraindication to use or indication to change the dosage of the preparation. In some situations it may be necessary to carry out specific check-ups.
The preparation is intended only for nasal use (spray nasal). Protect eyes from contact with the preparation. If the product accidentally gets into your eyes, rinse thoroughly with water.
Intranasal use of corticosteroids may result in systemic side effects, especially when used for long-term and / or high doses. However, the risk of systemic side effects after intranasal corticosteroids is significantly lower than with the oral administration of these drugs. Systemic side effects of corticosteroids may include inhibition of the natural production of steroid hormones by the adrenal cortex (decrease in blood cortisol levels), occurrence of Cushing's syndrome, slow growth in children and adolescents, decrease in bone density, cataracts, glaucoma and psychiatric disorders such as increased psychomotor activity , sleep disturbances, anxiety, depression or aggression (especially in children).
Your doctor will advise you to use the lowest effective dose to control the symptoms of rhinitis.It is recommended that, during long-term treatment with nasal corticosteroid, regular control of growth in children. If growth slows, your doctor will check your treatment and recommend that you reduce the dose accordingly.
The use of doses higher than recommended may cause clinically significant suppression of adrenocortical function. If you are using high doses of steroids and are particularly vulnerable to stress or planning surgery, please inform your doctor who can assess the degree of adrenal insufficiency and recommend you additionally oral corticosteroids.
If other preparations containing corticosteroids (including, for example, aerosols, inhalers, tablets, ointments, creams) are used in parallel, a physician should be consulted who will adjust their dosage accordingly.
If you have used steroids / steroids orally (acting systemically) and replace them with nasal steroids (fluticasone), consult a physician and explain what precautions you should keep. There is a risk of symptoms of adrenocortical insufficiency.
Intranasal or inhaled corticosteroids may cause the development of glaucoma and / or cataracts. Persons with visual impairment, with increased intraocular pressure or suspected glaucoma or cataracts (also in the past) should remain under the special supervision of a physician.
The concomitant use of the preparation with ritonavir should be avoided.
Caution should be exercised in patients with severe hepatic impairment; in this group of patients it is possible to increase exposure to fluticasone and the occurrence of systemic side effects.
Additional information about the other ingredients of the preparation:
· The preparation contains benzalkonium chloride, which may cause irritation of the nasal mucosa; if irritation / discomfort occurs during the use of the preparation, a physician should be consulted.
Does this preparation affect the ability to drive vehicles?
There was no effect on the ability to drive or use machines / machines.
Dosage of Avamys
The preparation is a nasal spray. 1 dose (1 press) contains 27.5 μg of active substance. Do not exceed the recommended doses because it will not increase the effectiveness of the drug and may harm your health and life. If you have any doubts regarding the use of the preparation, consult a physician.
For effective treatment, the product should be used regularly according to the dosing schedule. The onset of action occurs approximately 8 hours after administration of the preparation. Full effect usually occurs after a few days of regular use. The duration of treatment should be limited to the period of exposure to the allergen.
The container should be shaken before each use. Before using the dispenser for the first time, press the button on the side of the container at least 6 times to hold the container vertically until a homogeneous mist is visible. Reprocessing the dispenser by pressing the button 6 times will only be necessary if the dispenser has not been protected with a nozzle for 5 days or if the nasal spray has not been used for 30 days or more. After each use, clean the dispenser and attach the cap to it.
Adults and children over 12:
Initially 2 doses for each nostril once daily (total daily dose 110 μg). Once the symptoms have been controlled, one dose can be used in each nostril once daily (total daily dose 55 μg) in maintenance therapy.
Always seek the lowest dose to ensure effective symptom control. If you have good control over your symptoms, your doctor may recommend a dose reduction.
Children 6-11. age:
Initially 1 dose for each nostril once daily (total daily dose 55 μg). If this dose does not allow symptoms control, your doctor may prescribe 2 doses to each nostril once daily (total daily dose 110 μg). Once the symptoms have been controlled, it is recommended to reduce to 1 dose to each nostril once daily (total daily dose 55 μg).
Children under 6:
The safety of the preparation in this age group has not been determined.
There is no need to adjust the dosage in the elderly and in patients with impaired renal function or mild to moderate hepatic impairment.Caution should be exercised in people with severe hepatic impairment because of the increased risk of systemic adverse reactions of corticosteroids.
Can I use Avamys during pregnancy and breastfeeding?
During pregnancy, do not use any medicine without consulting your doctor!
It is very important that before using any medicine during pregnancy or breastfeeding, consult a physician and explain beyond any doubt the potential risks and benefits associated with the use of the drug. If you are pregnant or plan to become pregnant, please inform the doctor prescribing the prescription for this medicine.
There are no adequate data on the safety of the preparation in pregnant women. In pregnant women, the use of the preparation is limited only to cases when the doctor deems it absolutely necessary and when in the physician's opinion the expected benefits clearly outweigh the possible risks. Only a doctor can assess the benefit / risk ratio in your case!
It is not known whether after intranasal administration the active substance is excreted in human milk. Do not use the product during breastfeeding unless the doctor considers it absolutely necessary.
Can I use other preparations in parallel?
Tell your doctor about all medicines you have recently taken, including those that are over the counter. In particular, inform your doctor if you use:
· Ritonavir (a medicine used to treat HIV infection)
· Ketoconazole, itraconazole (antifungal medicines)
· Oral corticosteroids or injections or other forms of corticosteroids (inhalation preparations used to treat asthma, ointments, creams).
Ritonavir and other potent inhibitors of cytochrome P 450 3A4 isoenzyme (ketoconazole) can significantly increase fluticasone plasma concentrations. Increased fluticasone levels are associated with the risk of systemic side effects of corticosteroids (Cushing's syndrome, suppression of the adrenal cortex). Do not use the product in parallel with ritonavir. Avoid parallel use with other drugs that inhibit cytochrome P450 3A4 isoenzyme activity.
What side effects can occur?
Like all medicines, Avamys can also cause side effects, although it will not occur in all patients who use this medicine. Remember that the expected benefits of using the drug are usually greater than the damage resulting from the occurrence of side effects.
The following may occur: irritation of the nasal mucous membranes (burning, tenderness, discomfort), nosebleeds, nose ulcers, nasal pain, dry nose, headaches, transient eye changes, slower growth of children. Rarely possible hypersensitivity reactions (rash, pruritus, urticaria) and angioneurotic edema and anaphylactic reactions (these reactions may be severe and may be life-threatening, angioedema of the tongue, throat, larynx that may impede breathing, bronchospasm, hypotension, shock). Systemic side effects of corticosteroids may occur (including adrenal suppression, Cushing's syndrome, lunar face, slow growth in children and adolescents, decrease in bone density, cataracts, glaucoma) especially if the preparation is used in high doses and / or long-term.