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Note: reimbursed drug prices are in line with the regulations in force from July 1, 2018.
The preparation contains the substance:mesalazine
The drug is available on prescription
What is Asamax?
Anti-inflammatory preparation used in diseases of the gastrointestinal tract.
What does Asamax contain and how does it work?
The active substance of the preparation is mesalazine (another name is aminosalicylic acid), a derivative of salicylic acid. A drug with anti-inflammatory effect, used to treat inflammatory bowel diseases. Mesalazine inhibits the activity of cyclooxygenases and lipoxygenases, i.e. enzymes involved in the synthesis of prostaglandins and leukotrienes. Prostaglandins and leukotrienes play a significant role in the development of inflammation. Mesalazine also prevents the synthesis of other inflammatory mediators and reduces the harmful effects of free radicals. Thanks to a special coating, enteral messengers are released in the final section of the small intestine and the initial section of the large intestine. It has a direct anti-inflammatory effect in the intestinal wall. Mesalazine and its metabolites are excreted partly in the urine and partly in the faeces. Mesalazine crosses the placenta and into breast milk.
When should I use Asamax?
The preparation is indicated for use:
· In mild or moderate forms of ulcerative colitis, both in the acute phase and in the remission phase of the disease
· In Crohn's disease in the colon, both in the acute phase and in the remission phase of the disease.
When not to use this preparation?
Unfortunately, even if there are indications to use the preparation, it can not always be used. You can not use the preparation if you are allergic (you are hypersensitive) to any of the ingredients of the preparation or to other salicylates.
The preparation can not be used in case of severe renal and / or hepatic failure.
Take special care with Asamax?
Certain diseases and other circumstances may constitute a contraindication to use or indication to change the dosage of the preparation. In some situations it may be necessary to carry out specific check-ups.
Experience in the use of the preparation in children 6-18. is relatively small and there is no full data on the safety and efficacy of the preparation in this age group.
Before starting treatment and during the period of application, the doctor will recommend performing appropriate diagnostic tests, such as: complete blood count with smear and blood creatinine, determination of liver enzymes, and urinalysis. At the beginning of the treatment, the tests should be performed after 2 weeks from the start of treatment, and then 2-3 times, with an interval of 4 weeks. If the results are corr
ect, subsequent tests should be performed every 3 months, and if additional symptoms occur, the tests should be performed immediately.
Take special care if the preparation is used in people with hepatic impairment.Do not use the preparation in people with impaired renal function. If your kidney function worsens during treatment, you should immediately consult your doctor for early diagnosis of the kidney toxicity.
People with bronchial asthma or lung disease should remain under special medical observation during treatment.
In the event of symptoms such as: abdominal pain, stomach and intestinal cramps, bloody diarrhea, fever, severe headache and rash, stop using the product immediately and consult a physician. These symptoms may be indicative of an acute intolerance syndrome. Particular care should be taken in patients with adverse reactions after sulfasalazine.
The preparation may reduce sperm count and motility, which may affect fertility. This effect is usually reversible after treatment.
Does this preparation affect the ability to drive vehicles?
There was no effect of the preparation on the ability to drive vehicles and operate equipment / machines.
Dosage of Asamax
The preparation is in the form of gastro-resistant tablets for oral use. Do not exceed the recommended doses because it will not increase the effectiveness of the drug and may harm your health and life. If you have any doubts regarding the use of the preparation, consult a physician.
The tablets should be taken after a meal, whole (do not chew, chew), with liquid.
Ulcerative colitis: in the acute phase 2-4,5 g per day in 3-4 divided doses; in the remission phase, to prevent relapse, at least 2 g per day in divided doses.
Leśniowski and Crohn's disease: in the acute phase up to 4.5 g per day in 3-4 divided doses; in the remission phase, to prevent relapse, up to 3 g daily in 3-4 divided doses.
Youth and children over 6:
There are limited data on the use of the preparation in children 6-18. age. The doctor will determine the dose individually; at the stage of acute symptoms in children after the age of 6, initially 30-50 mg / kg body weight per day in divided doses. The maximum dose is 75 mg / kg body weight per day in divided doses. The maximum total daily dose is 4 g.
During the remission period initially 15-30 mg / kg body weight per day in divided doses. The maximum dose is 75 mg / kg body weight per day in divided doses. The maximum total daily dose is 2 g.
For children weighing up to 40 kg, it is recommended to administer 1/2 dose for adults, and for children weighing more than 40 kg, dosing is recommended as for adults.
Can I use Asamax during pregnancy and breastfeeding?
During pregnancy, do not use any medicine without consulting your doctor!
It is very important that before using any medicine during pregnancy or breastfeeding, consult a physician and explain beyond any doubt the potential risks and benefits associated with the use of the drug. If you are pregnant or plan to become pregnant, please inform the doctor prescribing the prescription for this medicine.
The use of the preparation during pregnancy is only allowed if the doctor considers it absolutely necessary and if in the opinion of the physician the expected benefits clearly outweigh the possible risks. Only a doctor can assess the benefit / risk ratio in your case!
Before using the preparation during breastfeeding, consult a doctor. Mesalazine is excreted in human breast milk.
Can I use other preparations in parallel?
Tell your doctor about all medicines you have recently taken, including those that are over the counter.
The preparation may affect the action of anticoagulants, coumarin derivatives (eg Warfarin
If mercaptopurine, thioguanine or azathioprine are used during treatment, haematological disorders (leukopenia) and increased bone marrow suppression may occur.
What side effects can occur?
Like all medicines, Asamax 250, -500 can cause side effects, although they will not occur in all patients who use this medicine. Remember that the expected benefits of using the drug are usually greater than the damage resulting from the occurrence of side effects.
Rarely: headache and dizziness, myocarditis, pericarditis, abdominal pain, diarrhea, bloating, nausea and vomiting. Very rare: hematological disorders (agranulocytosis, thrombocytopenia, leukopenia, neutropenia, aplastic anemia), hypersensitivity reactions (allergic eczema, drug-induced fever, lupus erythematosus, pancolitis), peripheral neuropathy, allergic and pulmonary fibrosis (dyspnoea, cough, bronchospasm, inflammation alveoli, pulmonary eosinophilia, pulmonary infiltrates, pneumonia), hepatitis, bile retention, hepatic dysfunction, acute pancreatitis, renal failure, interstitial nephritis, transient after discontinuation of the product reduction in sperm count and motility, muscle and joint pain baldness.
Other preparations on the Polish market containing mesalazine
Asamax 250 (suppositories)
Asamax 250 (enteric-coated tablets)
Asamax 500 (suppositories)
Pentasa (prolonged release tablets)
Pentasa (rectal suspension)
Pentasa (prolonged release granules)
Salofalk (enteric-coated tablets)
Salofalk (rectal suspension)
Salofalk 1 g (suppositories)