|The name of the preparation
||Character; dose; package
||Price after refund
||In which pharmacy?
|Apap pain and C plus fever
1 tabl contains: 500 mg of paracetamol, 300 mg of ascorbic acid;
Note: reimbursed drug prices are in line with the regulations in force from July 1, 2018.
The drug is available without a prescription
What is Apap pain and C plus fever?
It is a medicine with analgesic and antipyretic effect, containing Paracetamol
and vitamin C.
What does the pain and C Plus fever contain and how does Apap work?
It is a combined preparation containing paracetamol and vitamin C (ascorbic acid). Paracetamol has analgesic and antipyretic effects. The mechanism of its action consists in inhibiting the activity of cyclooxygenase 2 (COX-2) in the brain and in the spinal cord, the enzyme responsible for the synthesis of prostaglandins. Paracetamol has no anti-inflammatory activity because it practically does not inhibit the activity of cyclooxygenases and prostaglandin synthesis in peripheral tissues. It does not damage the gastric mucosa. It does not inhibit platelet aggregation and does not affect the coagulation process. The second component of the preparation is vitamin C (ascorbic acid), necessary in many metabolic processes (it participates in oxidation and reduction processes, is an antioxidant, takes part in the biosynthesis of collagen, folic acid, adrenocortical hormones, facilitates the absorption of iron). After oral administration, paracetamol and Ascorbic acid
are well and rapidly absorbed from the gastrointestinal tract. Both components of the preparation penetrate the placenta and into breast milk.
When to use Apap pain and C plus fever?
The product is indicated for the short-term treatment of cold or flu symptoms such as fever, headache, sore throat, muscle and bone-joint pain.
When not to use this preparation?
Unfortunately, even if there are indications to use the preparation, it can not always be used. You can not use the preparation if you are allergic (you are hypersensitive) to any of the ingredients.
The use of the preparation is contraindicated in people:
with severe renal or hepatic impairment
with viral hepatitis
with congenital deficiency of Glucose
suffering from alcoholism
patients with phenylketonuria
MAO inhibitors that have been used concurrently or over the last two weeks
using zidovudine (AZT)
in children up to 12 years old.
Take special care with Apap pain and C plus fever?
Certain diseases and other circumstances may constitute a contraindication to use or indication to change the dosage of the preparation. In some situations it may be necessary to carry out specific check-ups.
Other paracetamol-containing medicines should not be used in parallel because of the risk of overdose and serious side effects. Check whether other medicines used do not contain paracetamol.
Caution should be exercised in patients with impaired renal or hepatic function, in patients with bronchial asthma and patients with hemochromatosis.
In people who are tired, starved or regularly consuming alcohol there is an increased risk of liver damage.
Alcohol should not be consumed while using the product. Consumption of alcohol during the use of the preparation may lead to toxic liver damage and its inefficiency.
Additional information about the other ingredients of the preparation:
the preparation contains 167 mg of sodium in one tablet, which should be taken into account in people using a low sodium diet;
the preparation contains aspartame (source of phenylalanine) and should not be used by patients with phenylketonuria.
Does this preparation affect the ability to drive vehicles?
There was no effect on the ability to drive or use machines / machines.
Dosing with Apap pain and C plus fever
The preparation is in the form of effervescent tablets for oral use. Use the preparation as recommended. Do not exceed the recommended doses because it will not increase the effectiveness of the drug and may harm your health and life. If you have any doubts regarding the use of the preparation, consult a physician.
Adults and adolescents after the age of 12: 1 tablet, every 4-6 hours. Take after dissolving the tablet in 0.5 glasses of water. Do not use more than 3 tablets a day.
Do not use in children under 12 years of age.
Can I use Apap pain and C plus fever during pregnancy and breastfeeding?
During pregnancy, do not use any medicine without consulting your doctor!
It is very important that before using any medicine during pregnancy or breastfeeding, consult a physician and explain beyond any doubt the potential risks and benefits associated with the use of the drug. If you are pregnant or planning to become pregnant, consult your doctor before using the product.
The use of the preparation in pregnant women and during breastfeeding is possible only when absolutely necessary.
Before using the product during pregnancy or during breastfeeding, please consult your doctor.
Can I use other preparations in parallel?
Tell your doctor about all medicines you have recently taken, including those that are over the counter. In particular, consult your doctor if you are using any of the medicines listed below, as you may need to change your dosage or stop taking your medicine.
It must not be used with other paracetamol medicines (risk of paracetamol overdose and serious side effects).
Metoclopramide and other preparations that enhance gastrointestinal peristalsis increase the rate of absorption of paracetamol.
Preparations that inhibit gastrointestinal peristalsis delay the absorption of paracetamol.
Do not use with MAO inhibitors
or within 2 weeks after discontinuing their use. Paracetamol used with MAO inhibitors may cause arousal and high fever.
Do not use with zidovudine. Paracetamol may increase the toxic effects of zidovudine (risk of neutropenia, risk of liver damage).
Paracetamol taken for a prolonged period of time may increase the effect of anticoagulants from the coumarin group (eg Warfarin
), increasing the risk of bleeding.
Caffeine enhances the analgesic effect of paracetamol.
Medicines increasing hepatic metabolism, including rifampicin, isoniazid, antiepileptics (eg phenytoin, carbamazepine), barbiturates (eg phenobarbital), hypnotics and alcohol, used in parallel with paracetamol can lead to liver damage, even at the recommended doses.
Paracetamol slows down the excretion of chloramphenicol.
The use of paracetamol with non-steroidal anti-inflammatory drugs (NSAIDs) in people with impaired renal function may cause further deterioration of their function and severity of failure.
Consumption of alcohol during the use of the preparation may lead to toxic liver damage and its inefficiency.
Ascorbic acid increases the absorption of aluminum and iron.
Paracetamol may affect the results of some laboratory tests (such as the determination of blood glucose).
What side effects can occur?
Like all medicines, Apap C Plus can cause side effects, although they will not occur in all patients who use this medicine.Remember that the expected benefits of using the drug are usually greater than the damage resulting from the occurrence of side effects.
Possible side effects include: nausea, vomiting, renal dysfunction, renal colic, renal papillary necrosis, acute renal failure
, urolithiasis, liver dysfunction (in the case of paracetamol overdose may experience acute liver failure, liver damage or necrosis), haematological abnormalities ( thrombocytopenia, leukopenia, neutropenia, agranulocytosis, haemolytic anemia). Possible hypersensitivity reactions: pruritus, urticaria, rash, erythema as well as life-threatening angioedema and anaphylactic shock (symptoms may include swelling of the larynx, tongue, throat, shortness of breath, bronchospasm, confluent sweating, increased heart rate, rapid drop in blood pressure, loss of consciousness).
Other preparations on the Polish market containing ascorbic acid + paracetamol
Efferalgan Vitamin C (effervescent tablets)