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► Aldan 5 (amlodipine) - Practical Medicine

Aldan 5 (amlodipine) - tablets

The name of the preparation Character; dose; package Manufacturer Price 100% Price after refund In which pharmacy?
Aldan 5 tablets; 5 mg; 30 tabl. Polfarmex 6.40 0.00
1.96
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Note: reimbursed drug prices are in line with the regulations in force from July 1, 2018.

The preparation contains the substance:amlodipine

The drug is available on prescription

What is Aldan?

A drug blocking Calcium channels. It mainly works on blood vessels causing a reduction in muscle tone of the vascular walls and vasodilation. It lowers blood pressure and reduces peripheral vascular resistance.

What does Aldan contain and how does it work?

The active substance is Amlodipine , a dihydropyridine derivative belonging to a group of medicines called calcium channel blockers (or calcium channel blockers). Calcium antagonists act by blocking calcium channels, structures that allow the passage of calcium ions across the cell membrane. Amlodipine blocks the inflow of calcium ions from the extracellular space into the smooth muscle cells of the walls of the blood vessels and to a lesser extent into the cells of the heart muscle. Increasing the intracellular calcium concentration is necessary for the contraction of muscle cells. Amlodipine works mainly on peripheral blood vessels. Blockage of calcium channels reduces the tension of the vessel walls and vasodilation. The immediate effect of this action of amlodipine is lowering blood pressure. Enlargement of peripheral arterioles reduces peripheral vascular resistance, which relieves the heart (it reduces energy consumption by the myocardium and its oxygen demand). Coronary arteries are also likely to expand, which increases oxygen transport to the myocardium, also in patients with vasospastic angina (Prinzmetal). As a result, in patients with angina pectoris, exercise tolerance increases (the time to angina pain increases during exercise) and the incidence and severity of angina pains decreases. The clinical condition of patients with angina pectoris improves and Nitroglycerin consumption decreases.
Preparations from this group are used as medicines to lower blood pressure and to relieve symptoms of angina. In hypertensive patients, taking once daily provides a clinically significant reduction in blood pressure, both standing and lying, for 24 hours. The effect of amlodipine appears gradually, so it does not cause sudden hypotension. To obtain a stationary concentration of amlodipine in the blood requires 7.-8. days of daily use.

When should I use Aldan?

The preparation is indicated for the treatment of:
Hypertension
· Stable angina
· Vasospastic angina (Prinzmetal).

When not to use this preparation?

Unfortunately, even if there are indications to use the preparation, it can not always be used. You can not use the preparation if you are allergic (you are hypersensitive) to any of the ingredients of the preparation or to dihydropyridine derivatives.
You can not use the preparation if you are present:
· Hypotension
· Cardiogenic shock
· Clinically significant aortic stenosis
· Unstable angina with the exception of vasospastic form (Prinzmetal).
The preparation should not be used during pregnancy unless it is absolutely necessary in the opinion of the doctor. The preparation is contraindicated during breast-feeding.

Take special care with Aldan?

Certain diseases and other circumstances may constitute a contraindication to use or indication to change the dosage of the preparation. In some situations it may be necessary to carry out specific check-ups.
When initiating treatment and increasing the dose in people with significant organic changes (severe stenosis) in the coronary arteries, exacerbation of coronary heart disease or myocardial infarction may occur (causation with the use of the preparation has not been confirmed). Be careful.
Caution should be exercised in patients with heart failure , especially severe (NYHA grade III and IV); in this group of patients, there is an increased risk of pulmonary edema during the period of application.
Caution should be exercised in patients with aortic stenosis and other antihypertensive agents due to the risk of excessive hypotension.
People with hepatic impairment should be treated with caution as the effect of the preparation may be exacerbated. It is necessary to adjust the dosage by the doctor (it is recommended to reduce the dose).
There is no need to adjust the dose in patients with impaired renal function. Amlodipine is not removed during dialysis.
In the elderly, it is recommended to start treatment with the lowest possible dose and gradually increase it.
Use of the preparation in people with severe heart failure (NYHA class IV) requires caution.
The preparation should not be sipped with grapefruit juice because it increases the bioavailability of amlodipine.
There are no clinical data on the safety and efficacy of the preparation in children.

Does this preparation affect the ability to drive vehicles?
The reactions on the preparation are individually varied. The preparation may, especially in the initial period of treatment, cause headache, dizziness, fatigue, fainting, drowsiness or other symptoms that may impair psychophysical fitness, ability to drive vehicles and operate equipment / machines.

Dosage of Aldan

The preparation is in the form of tablets. It is intended for oral use. Do not exceed the recommended doses because it will not increase the effectiveness of the drug and may harm your health and life. If you have any doubts regarding the use of the preparation, consult a physician.
Adults:
Hypertension: the usual recommended starting dose is 5 mg once daily. The maximum dose is 10 mg a day. The doctor will individually adjust the dosage depending on the response to treatment. In elderly patients and patients with liver failure, the doctor will start treatment at a lower dose (usually 2.5 mg once daily). If necessary, gradually, at intervals of 1 to 2. weekly, will increase the dose. If monotherapy is ineffective, your doctor may include other antihypertensive agents (beta blockers, angiotensin converting enzyme inhibitors or thiazide diuretics).
Stable angina, vasospastic angina (Prinzmetal): the usual recommended dose is 5-10 mg once daily. In elderly patients and in patients with hepatic impairment, it is recommended to start treatment with a dose of 5 mg daily. The preparation, if prescribed by a doctor, may be used in parallel with thiazide diuretics, beta-blockers, angiotensin-converting enzyme inhibitors, prolonged-release nitrates, and sublingual nitroglycerine.
There is no need to adjust the dose in patients with impaired renal function. Amlodipine is not removed during dialysis.
There are no clinical data on the safety and efficacy of the preparation in children.

Can Aldan be used during pregnancy and breastfeeding?

During pregnancy, do not use any medicine without consulting your doctor!
It is very important that before using any medicine during pregnancy or breastfeeding, consult a physician and explain beyond any doubt the potential risks and benefits associated with the use of the drug.If you are pregnant or plan to become pregnant, please inform the doctor prescribing the prescription for this medicine.
Use of the preparation in pregnancy is only allowed if the doctor deems it absolutely necessary and a safer alternative medicine can not be used and when the doctor believes that the benefits associated with the treatment clearly outweigh the risks associated with the use of the preparation.
The use of the preparation during breast-feeding is contraindicated.

Can I use other preparations in parallel?

Tell your doctor about all medicines you have recently taken, including those that are over the counter.
The preparation, if prescribed by a doctor, may be used in parallel with thiazide diuretics, beta-blockers, angiotensin-converting enzyme inhibitors, sustained action, sublingual nitroglycerine, non-steroidal anti-inflammatory drugs, antibiotics, oral antidiabetic agents, Digoxin , Warfarin , estrogens, Lithium preparations, sympathomimetics.
Cimetidine, antacids containing aluminum or Magnesium and Sildenafil do not affect the pharmacokinetics of amlodipine.
Amlodipine does not affect the pharmacokinetics of Atorvastatin , digoxin, warfarin or cyclosporine.
Parallel consumption of grapefruit juice is not recommended, because grapefruit juice may affect the effect of amlodipine and may increase blood pressure in some people.
Preparations that reduce the activity of cytochrome P450 3A4 isoenzyme, such as, for example, diltiazem, Verapamil , azole antifungals (ketoconazole, Itraconazole ), protease inhibitors (ritonavir), macrolide antibiotics (erythromycin, Clarithromycin ) can inhibit the metabolism of amlodipine and increase its concentration in the blood and intensifying its operation. Caution should be exercised, especially in the elderly.
Preparations that increase the activity of the cytochrome P450 3A4 isoenzyme (such as, for example, rifampicin, St. John's wort, phenobarbital, phenytoin and carbamazepine) may reduce amlodipine levels in the blood and reduce its effect. Be careful.
Due to the aggregation of the antihypertensive effect of various preparations, amlodipine may potentiate the effect of parallel antihypertensive agents (such as beta-blockers, angiotensin-converting enzyme inhibitors, alpha-blockers, diuretics).

What side effects can occur?

Like all medicines, Aldan 5, -10 can cause side effects, although they will not occur in all patients using this medicine. Remember that the expected benefits of using the drug are usually greater than the damage resulting from the occurrence of side effects.
Common side effects include: swelling, headache and dizziness, drowsiness, fatigue, weakness, palpitations, redness of the face and flushing, nausea, abdominal pain. Uncommonly possible: tachycardia / bradycardia (increase / decrease in heart rate), chest pain, flutter / atrial flutter, hypotension, tingling or numbness (paresthesia), peripheral neuropathy, convulsions, constipation, indigestion, vomiting, diarrhea, pancreatitis, gingival hyperplasia, muscle aches and pains, joint pain, sexual dysfunction, depression, nervousness, sleep disturbances, urination disorders, mouth tremors, general weakness, back pain, hot flushes, malaise. Very rare: increased activity of liver enzymes, jaundice, skin rashes.

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Amlozek (tablets)
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Normodipine (tablets)
Norvasc (tablets)
Tenox (tablets)
Vilpin (tablets)