|The name of the preparation||Character; dose; package||Manufacturer||Price 100%||Price after refund||In which pharmacy?|
|Aerius||coated tablets; 5 mg; 10 tables||Merck Sharp & Dohme||15.50||Check|
|Aerius||coated tablets; 5 mg; 30 tabl.||Merck Sharp & Dohme||32.90||Check|
Note: reimbursed drug prices are in line with the regulations in force from July 1, 2018.
An antihistamine with antiallergic activity.
The active substance of the preparation is desloratadine, a second generation antihistamine (unlike first generation drugs, second generation antihistamines used at the recommended doses are practically free of sedation, because they do not affect the central nervous system). Desloratadine is the main active metabolite of Loratadin e. Desloratadine, like loratadine , is a histamine antagonist, selectively blocks peripheral histamine type 1 (H1) receptors. In this way, it circumferentially inhibits the action of histamine, a substance that causes allergic symptoms.In vitro desloratadine inhibits the release of cytokines by human mast cells and basophils. These mechanisms are probably responsible for reducing the allergic reaction. Relieves allergic symptoms such as sneezing, runny nose, swelling and itching of mucous membranes, tears and redness of the eyes, urticaria (relieves pruritus and reduces the number and size of urticaria changes).
Desloratadine is well absorbed after oral administration, the maximum concentration in blood is reached after about 3 hours. The enzyme responsible for the metabolism of desloratadine has not been known so far, so interaction with other drugs can not be ruled out. The effect of desloratadine persists for more than 24 hours.
The preparation is indicated for use in adults and adolescents after the age of 12 to relieve the symptoms associated with:
• with allergic rhinitis
• with urticaria.
Unfortunately, even if there are indications to use the preparation, it can not always be used. You can not use the product if you are allergic (you are hypersensitive) to any of the ingredients or to loratadine.
It is not recommended for pregnant women or breast-feeding women.
Certain diseases and other circumstances may constitute a contraindication to use or indication to change the dosage of the preparation. In some situations it may be necessary to carry out specific check-ups.
In case of suspected or confirmed kidney dysfunction, consult a doctor before using the product. Caution should be exercised in people with severe renal impairment.
Additional information about the other ingredients of the preparation:
• the product contains lactose; people with galactose intolerance, lactase deficiency or malabsorption of Glucose -galactose should not use this preparation.
Does this preparation affect the ability to drive vehicles?
In clinical trials, there was no reduction in psychomotor performance in people taking desloratadine. However, before driving or operating machinery / equipment, check the individual response to the medicine and be careful.
Very rarely, some people may have side effects such asdrowsiness that may impair the ability to drive vehicles and operate machinery / machines.
The preparation is in the form of coated tablets for oral use. Can be taken with or without food. Do not exceed the recommended doses, because it will not increase the effectiveness of the drug and may harm your health and life. If you have any doubts about the use of the preparation, consult your doctor.
Adults and adolescents after the age of 12: 5 mg once daily.
It is not recommended to use the tablet formulation in children under 12 years of age due to the lack of data on the safety and efficacy of the preparation in this age group.
If you have kidney problems, your doctor will adjust the dosage.
During pregnancy, do not use any medicine without consulting your doctor!
It is very important that you consult a physician before taking any medicine during pregnancy or breastfeeding and explain beyond any doubt the potential risks and benefits of using the medicine. If you are pregnant or planning to become pregnant, please inform your prescribing physician about this medicine.
It is not recommended for pregnant women or women who are breast-feeding.
Tell your doctor about all medicines you have recently taken, including those that are over the counter.
Parallel administration of the preparation with ketoconazole or Erythromycin does not result in clinically significant interactions.
In clinical trials, desloratadine did not potentiate the effects of alcohol and psychomotor disorders caused by alcohol. However, alcohol intolerance and alcohol intoxication have been reported after the medicine has been placed on the market.
Like all medicines, Aerius can also cause side effects, although it will not occur in all patients who use this medicine. Remember that the expected benefits of using the drug are usually greater than the damage resulting from the occurrence of side effects.
Fatigue, dry mouth, headache and dizziness, drowsiness, insomnia, psychomotor agitation, convulsions, hallucinations, increased heart rate (tachycardia), palpitations, QT prolongation in ECG, arrhythmia, nausea, vomiting may occur , abdominal pain, diarrhea, indigestion, abnormal liver function (including increased liver enzymes, increased bilirubin, hepatitis), hypersensitivity to light, muscle pain, hypersensitivity reactions (rash, urticaria, pruritus) and Anaphylactic reactions (including severe reactions that may be life-threatening, including swelling of the throat, larynx, bronchospasm, dyspnea, hypotension, anaphylactic shock).
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