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► Azopt (brinzolamide) - Practical Medicine

Azopt (brinzolamide) - eye drops, suspension

The name of the preparation Character; dose; package Manufacturer Price 100% Price after refund In which pharmacy?
Azopt eye drops, suspension; 10 mg / ml; 5 ml Novartis Europharm 38.82 0.00
11.53
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Note: reimbursed drug prices are in line with the regulations in force from July 1, 2018.

The preparation contains the substance:brinzolamide

The drug is available on prescription

What is Azopt ?

A drug from the group of carbonic anhydrase inhibitors applied topically to the eye (into the conjunctival sac) to reduce intraocular pressure.

What does Azopt contain and how does it work?

The active substance is brinzolamide. It is a substance from the group of sulfonamides, used topically in ophthalmology to reduce intraocular pressure. It inhibits the activity of the enzyme dehydratase (anhydrase) carbonate. Carbonate dehydratase is an enzyme found in many tissues of the body, including the eye. Inhibition of this enzyme in the processes of the ciliary body of the eye leads to a decrease in the production of aqueous humor and, consequently, to lower intraocular pressure. After administration to the conjunctival sac, brinzolamide exerts a local action, it is also absorbed into the general circulation. Brinzolamide and its metabolites are mainly excreted by the kidneys. Brynzolamide is used as monotherapy or in combination with beta-blockers or prostaglandin analogues.

When to use Azopt?

The preparation is indicated to lower the increased intraocular pressure in patients with:
· Ocular hypertension
· Open angle glaucoma.
The preparation can be used:
· Monotherapy in adults who do not respond adequately to beta-blockers or in whom the use of beta-blockers is contraindicated
· In combination therapy with beta-blockers (another name is beta-blockers) or prostaglandin analogues.

When not to use this preparation?

Unfortunately, even if there are indications to use the preparation, it can not always be used. You can not use the preparation if you are allergic (you are hypersensitive) to any of the ingredients or other sulfonamides.
Contraindication is contraindicated in patients with severe renal impairment (creatinine clearance less than 30 ml / min) or with hyperchloraemic acidosis.
The preparation is not recommended in people with hepatic impairment due to lack of clinical experience.
It should not be used in pregnant women, in women who are breastfeeding or in women of childbearing potential who do not use effective methods of preventing pregnancy.

Take special care with Azopt?

Certain diseases and other circumstances may constitute a contraindication to use or indication to change the dosage of the preparation. In some situations it may be necessary to carry out specific check-ups.
The preparation is intended only for external application, locally to the conjunctival sac.
Brynzolamide is a sulfonamide and, despite local application, it is absorbed into the systemic circulation. Therefore, adverse reactions characteristic of sulfonamides of general use (e.g.orally), including severe hypersensitivity reactions such as Stevens and Johnson syndrome, toxic epidermal necrolysis, or severe hematological disorders. If you suspect any hypersensitivity symptoms, please consult your doctor immediately (before re-applying the preparation). The doctor may recommend discontinuation of the preparation (in severe cases, immediate treatment may be necessary).
Oral use of carbonic anhydrase inhibitors may be associated with urolithiasis due to disturbances of the acid-base balance. The possibility of such disorders should be considered when using the preparation, because brinzolamide is absorbed into the systemic circulation.
There are no data on the use of the preparation in premature babies (born before the 36th week of pregnancy) or in newborns in the first week of life. In the case of significant renal tubular hypoplasia, the doctor will decide whether the preparation can be used, due to the risk of metabolic acidosis.
Brinzolamide is absorbed into the systemic circulation and, in the elderly, may, like oral medications in this group, impair the ability to perform tasks requiring increased concentration and / or motor coordination.
Co-administration with other carbonic anhydrase inhibitors is not recommended orally (systemically acting) due to the risk of increased activity and side effects.
There are insufficient data on the efficacy and safety of the preparation in patients with glaucoma in the course of exfoliative pseudoexfoliation syndrome and pigment glaucoma. The use of the preparation in these groups of patients requires careful attention and close monitoring of intraocular pressure. There are no data on the use of the preparation in patients with obstructed angulation glaucoma and the use of the preparation in this group of patients is not recommended.
There are no data on the effect of the preparation on Corn eal endothelial function in patients with corneal damage, especially in patients with low corneal endothelial cells. During the period of application, persons using contact lenses should remain under careful medical supervision. The preparation may affect the degree of corneal hydration which may increase the corneal risk associated with the use of contact lenses. Staying under careful medical observation is also recommended in other cases of corneal damage, such as, for example, in patients with diabetes.
The preservative of benzalkonium chloride contained in the preparation may cause point or toxic ulcerative keratopathy. If the preparation is used in patients with dry eye or corneal lesions, careful medical supervision and observation of the patient is required.
The intraocular pressure changes were not studied after discontinuation of the preparation and it is not known whether there is a so-called rebound effect, i.e. a significant increase in intraocular pressure after a sudden discontinuation of the drug. The hypotensive effect should last for 5-7 days.
The safety of the preparation in patients wearing contact lenses has not been studied.
Additional information about the other ingredients of the preparation:
the preparation contains benzalkonium chloride as a preservative, which can accumulate in contact lenses and destroy them (cause discoloration); people who use contact lenses should remove them before instillation and wait at least 15 minutes before re-inserting.

Does this preparation affect the ability to drive vehicles?
Caution should be exercised because, when administered to the eye, transient visual disturbances may occur which may impair the ability to drive vehicles and operate machinery / equipment. If visual disturbances occur, do not drive or operate mechanical devices until the disorder is resolved and acute vision returns.
Brinzolamide is absorbed into the systemic circulation and, in the elderly, may, like oral medications in this group, impair the ability to perform tasks requiring increased concentration and / or motor coordination.

Dosage of Azopt

The preparation is in the form of eye drops. Use the product as directed by your doctor.Do not exceed the recommended doses because it will not increase the effectiveness of the drug and may harm your health and life. If you have any doubts regarding the use of the preparation, consult a physician.
Adults: usually 1 drop 2 to 3 times a day, into the conjunctival sac.
To limit the systemic absorption of the active substance, it is recommended to close the eyelid or to gently compress the Nasol abial duct after instillation of the drug.
If other medicines were used before in the treatment of glaucoma, the physician will specify an individual schedule for changing the treatment method; usually the drug should be discontinued and the preparation should be started the next day.
If other preparations administered to the eyes are used in parallel, wait at least 5 minutes between administrations of the next drugs.
Shake the bottle thoroughly before using the product. Keep the bottle tightly closed.
Wash your hands before using the product. Do not touch the surface of the eye or the eyelid or any other surface with the dropper tip, as this may contaminate the product and lead to eye infection. The infection can cause serious eye damage or blindness.
The safety and efficacy of the preparation has not been determined in children and adolescents up to 18 years of age and its use in this age group is not recommended.
Contraindication is contraindicated in patients with severe renal impairment (creatinine clearance less than 30 ml / min) or with hyperchloraemic acidosis.
The preparation is not recommended in people with hepatic impairment due to lack of clinical experience.

Can Azopt be used during pregnancy and breastfeeding?

During pregnancy, do not use any medicine without consulting your doctor!
It is very important that before using any medicine during pregnancy or breastfeeding, consult a physician and explain beyond any doubt the potential risks and benefits associated with the use of the drug. If you are pregnant or plan to become pregnant, please inform the doctor prescribing the prescription for this medicine.
It should not be used in pregnant women, in women who are breastfeeding or in women of childbearing potential who do not use effective methods of preventing pregnancy.

Can I use other preparations in parallel?

Tell your doctor about all medicines you have recently taken, including those that are over the counter.
No specific interaction studies have been performed with other drugs.
The use of the preparation with prostaglandin analogs and with Timolol eye drops does not cause interaction.
The brinzolamide contained in the preparation is a carbonic anhydrase inhibitor. If the preparation is used in parallel with other carbonic anhydrase inhibitors when taken orally (acting systemically), there is a risk of increased activity and side effects, such as acid-base imbalance. Combination therapy is not recommended.
Caution should be exercised if drugs inhibiting the activity of cytochrome P450 3A4 is co-administered, such as, for example, ketoconazole, Itraconazole , Clotrimazole , ritonavir, troleandomycin; these drugs may inhibit brinzolamide metabolism, but should not cause accumulation.
If other preparations administered to the eyes are used in parallel, wait at least 5 minutes between administrations of the next drugs.

What side effects can occur?

Like all medicines, Azopt can also cause side effects, although it will not occur in all patients who use this medicine. Remember that the expected benefits of using the drug are usually greater than the damage resulting from the occurrence of side effects.
Local eye / eye reactions such as blurred vision, blurred vision, eye irritation, eye pain, dry eye, eye discharge, pruritus, ocular and conjunctiva congestion, feeling of a foreign body in the eye, corneal erosion may occur. , keratitis, punctate keratitis, corneal injury, increased intraocular pressure, conjunctivitis, thyroiditis, photophobia, abnormal sensation in the eye, scleral and / or corneal discoloration, subconjunctival cyst, eyelid pruritus, blepharitis, eyelid edema, tearing , loss of eyelashes.
In addition, systemic side effects may occur, such as: headache and dizziness, bitter or unusual taste in the mouth, memory problems, movement disorders, paresthesia, sensory disturbances, tremors, apathy, depression, nightmares, insomnia / drowsiness, nervousness, noise in ears, reduction / increase in heart rate, arrhythmias, palpitations, cardiorespiratory failure, angina pectoris, chest pain, shortness of breath, airway hyperresponsiveness, cough, asthma, pharyngitis and sinusitis, rhinitis, throat irritation, pain larynx and throat, runny nose, inflammation of the mouth, inflammation of the esophagus, diarrhea, nausea, vomiting, indigestion, abdominal pain, abnormal liver function tests, reduced number of red blood cells, increase in blood chloride, back pain, muscle cramps, muscle aches and pains joints, kidney pain, increased frequency of urination, dysfunction of the sec (impotence), malaise, weakness, fatigue, peripheral edema, hypersensitivity reactions (including urticaria, rash, pruritus, angioneurotic edema ), alopecia, dermatitis, erythema.
Brynzolamide is a sulfonamide and, despite local application, it is absorbed into the systemic circulation. Therefore, adverse reactions characteristic of sulfonamides commonly used (e.g., orally), including severe hypersensitivity reactions, such as Stevens and Johnson syndrome, toxic epidermal necrolysis, or severe hematological disorders, may occur.

Other preparations on the Polish market containing brinzolamide

Brinzolamide Genoptim (eye drops, solution)
Brinzolamide Sandoz (eye drops, suspension)
Optilamide (eye drops, suspension)