|The name of the preparation
||Character; dose; package
||Price after refund
||In which pharmacy?
||solution for injection;
1 amp. contains: 400 mg of glucosamine sulphate, 10 mg of lidocaine hydrochloride;
6 amps And with subst. + 6 amp. B from the beginning
Note: reimbursed drug prices are in line with the regulations in force from July 1, 2018.
The drug is available on prescription
What is Arthryl?
The product has a beneficial effect on the cartilage and may contribute to the relief of osteoarthritis.
What does Arthryl contain and how does it work?
The active substance of the preparation is glucosamine, an amino sugar found naturally in the human body. Glucosamine is part of glycosaminoglycan molecules, compounds with a characteristic structure, which in combination with proteins form so-called proteoglycans. These substances are an important component of the connective tissue, including cartilage. The mechanism of action of glucosamine in humans has not been fully elucidated. Glucosamine may stimulate the biosynthesis of glycosaminoglycans and proteoglycans, which may have beneficial and protective effects on cartilage and contribute to alleviating the symptoms of diseases associated with cartilage degeneration.
When should you use Arthryl?
The preparation is indicated for the symptomatic treatment of mild to moderate osteoarthritis of the knee joints.
When not to use this preparation?
Unfortunately, even if there are indications to use the preparation, it can not always be used. You can not use the preparation if you are allergic (you are hypersensitive) to any of the ingredients.
The preparation in sachets in the form of powder for oral solution contains aspartame and therefore the preparation is contraindicated in patients with phenylketonuria.
The preparation in ampoules, in the form of a solution for injection, contains lidocaine and for this reason its use is contraindicated in patients with impaired cardiac system function and in patients with untreated or non-responding to treatment of heart failure.
Use in children is not recommended.
When should you take special care with Arthryl?
Certain diseases and other circumstances may constitute a contraindication to use or indication to change the dosage of the preparation. In some situations it may be necessary to carry out specific check-ups.
Caution should be exercised when using the preparation in people who are allergic to crustaceans because the active substance contained in the preparation is obtained from these organisms.
Caution should be used when using a solution for injection in the case of:
· People with asthma, because these people may be more prone to allergic reactions to glucosamine, which is associated with a potential exacerbation of disease symptoms
· People with diabetes (at the beginning of treatment, close monitoring of blood glucose may be necessary)
· People with myasthenia gravis, epilepsy, congestive heart failure, bradycardia or respiratory failure, taking class III anti-arrhythmic drugs, due to the content of lidocaine
· People with hypovolaemia of various etiologies (haemorrhage, dehydration) or in people with impaired venous return, related to, for example, ascites or the presence of a large tumor in the abdomen (possibility of severe hypotension).
After administration of lidocaine, an increase in phosphocreatine kinase concentration is possible intramuscularly, which may interfere with the diagnosis of acute myocardial infarction.
There are no studies on the use of the product in people with renal or / and hepatic impairment. There are no indications that dosage should be changed in these patient groups, however, caution should be exercised in patients with severe renal or hepatic impairment.
Injecting lidocaine in place of an inflammatory process or infection may cause the weakening of lidocaine.
Lidocaine should be avoided in people with porphyria.
Additional information about the other ingredients of the preparation:
preparation in the form of powder for oral solution contains aspartame and is contraindicated in patients with phenylketonuria;
a powder formulation for oral solution contains 151 mg sodium per dose; this should be taken into account for people who are on a low sodium diet;
a solution for injection contains 40.3 mg sodium per dose; this should be taken into account for those who are on a low sodium diet.
Does this preparation affect the ability to drive vehicles?
There are no data on the effect of the preparation on the ability to drive and use machines / machines. In the event of headache or dizziness or drowsiness, do not drive or use machines / machines.
Dosage of Arthryl
It is a powder for oral solution (sachet) or solution for injection (ampoules). Use the product as directed by your doctor. Do not exceed the recommended doses because it will not increase the effectiveness of the drug and may harm your health and life. If you have any doubts regarding the use of the preparation, consult a physician.
Preparation in powder form for oral solution: Dissolve 1 sachet contents in a glass of water, mix well and drink. Take once a day, during a meal. The safety of the preparation has not been established for more than 3 years.
Solution for injection: 1-2 ampoules (400-800 mg) 3 times a week for 4-6 weeks. The preparation should be administered intramuscularly. Before use, the contents of the ampoule A (brown content) should be combined in the syringe with the contents of the ampoule B (colorless). Ampule A contains the active substance of the preparation and the ampoule B is a solvent.
Due to the lack of data, it is not recommended for use in children.
Elderly patients do not need to modify their dosage.
There are no studies on the use of the product in people with renal or / and hepatic impairment.
Can Arthryl be used during pregnancy and breastfeeding?
During pregnancy, do not use any medicine without consulting your doctor!
It is very important that before using any medicine during pregnancy or breastfeeding, consult a physician and explain beyond any doubt the potential risks and benefits associated with the use of the drug. If you are pregnant or plan to become pregnant, please inform the doctor prescribing the prescription for this medicine.
There are no data on the use of the product in pregnant women or during breast-feeding.
Can I use other preparations in parallel?
Tell your doctor about all medicines you have recently taken, including those that are over the counter.
Data on the interaction of the preparation with other drugs are limited. No interaction of the oral formulation with other drugs has so far been found.
In the case of a solution for injection, caution should be used in parallel:
· Anticoagulants from the group of coumarin derivatives (indicated control of blood coagulation parameters)
· Hydantoin derivatives (e.g., phenytoin) used to treat convulsions
Class III antiarrhythmics
· Cimetidine - elevation of lidocaine plasma concentrations may occur
· Beta-blockers - may inhibit the metabolism of lidocaine in the liver and increase its toxic effects
Muscle relaxants - high doses of lidocaine may increase their effect.
What side effects can occur?
Like all medicines, Arthryl can also cause side effects, although it will not occur in all patients who use this medicine. Remember that the expected benefits of using the drug are usually greater than the damage resulting from the occurrence of side effects.
Common: headache, drowsiness, fatigue, diarrhea, constipation, nausea, bloating, abdominal pain, indigestion.
Uncommon: erythema, rash, pruritus may occur.
In addition, with unknown frequency, allergic reactions, dizziness, visual disturbances, hair loss, reactions at the injection site may occur.