|The name of the preparation
||Character; dose; package
||Price after refund
||In which pharmacy?
||Bayer Pharma AG
|| b / d
||Bayer Pharma AG
Note: reimbursed drug prices are in line with the regulations in force from July 1, 2018.
The preparation contains the substance:moxifloxacin
The drug is available on prescription
An antibacterial drug generally used. A chemotherapeutic agent used to treat bacterial infections.
What does Avelox contain and how does it work?
The active substance of the preparation is moxifloxacin. It is a synthetic chemotherapeutic agent, a substance with a broad spectrum of antibacterial activity. Due to its chemical structure, it belongs to a group of medicines called fluoroquinolones. The mechanism of action of moxifloxacin is the inhibition of the bacterial enzyme activity necessary for the formation of the corr
ect structure of the bacterial nucleic acid (DNA). Bacterial DNA is destabilized, which in turn leads to inhibition of divisions and the death of the bacterial cell. After oral administration, it is absorbed very well and quickly from the gastrointestinal tract. It penetrates well into tissues, obtaining high concentrations especially in the tissues of the respiratory system and alveolar macrophages.
When should I use Avelox?
The preparation is indicated in people over 18 years of age in the treatment of infections caused by microbes sensitive to moxifloxacin, such as:
· Acute bacterial sinusitis (correctly diagnosed)
· Acute exacerbation of chronic bronchitis (correctly diagnosed)
· Community-acquired pneumonia (except in severe cases)
· Minor or moderate pelvic inflammatory disease (including infection of the upper tract of the reproductive tract, including salpingitis and endometritis) without ovarian and ovarian abscess or pelvis in the smaller pelvis.
The preparation is used if it is inappropriate to use antibacterial drugs, recommended in these infections as first-line treatments.
In the case of infections within the pelvic organs, if there is suspicion or it is certain that the bacteria caused them Neisseria gonorrhoeaeshould be used in combination with another antibiotic, due to the resistance of this bacterium to moxifloxacin.
The preparation can be used in the following cases as a continuation of treatment for a dożyn:
- community-acquired pneumonia
- complicated infections of the skin and subcutaneous tissue.
It must not be used to start treatment for any type of skin or subcutaneous tissue infections or severe community-acquired pneumonia.
When not to use this preparation?
Unfortunately, even if there are indications to use the preparation, it can not always be used. You can not use the preparation if you are allergic (you are hypersensitive) to any of the ingredients or other quinolones. You can not use the preparation if:
· You have tendinitis disease after using other quinolones
· You have severe liver failure or hepatic transaminases 5. your upper limit of normal
· You have risk factors for QT interval prolongation in ECG, such as any of the following: congenital or acquired QT prolongation, electrolyte abnormalities, especially low blood potassium (hypokalaemia), decreased heart rate (bradycardia), heart failure
, cardiac arrhythmias, use of drugs that may prolong the QT interval (e.g., some anti-arrhythmic drugs, tricyclic antidepressants, macrolide antibiotics).
Do not use the preparation in people under 18 years of age.
The preparation is contraindicated in pregnant women and during breastfeeding.
Take special care with Avelox?
Certain diseases and other circumstances may constitute a contraindication to use or indication to change the dosage of the preparation. In some situations it may be necessary to carry out specific check-ups.
Fluoroquinolone antibiotics administered as a general rule may cause hypersensitivity reactions, including anaphylactic shock (the occurrence of shock is possible even after a single dose). Some of the hypersensitivity reactions may be life-threatening and may be associated with acute circulatory failure, loss of consciousness, vasomotor edema, airway obstruction, dyspnea, urticaria and pruritus. If you suspect hypersensitivity reactions, please consult your doctor immediately. It may be necessary to stop using the preparation and to take immediate immediate treatment.
The preparation, like other fluoroquinolones, may cause a prolongation of the QT interval in the ECG record. Women and the elderly may be more sensitive to changes in the length of the QT interval. Special care should be taken by people who are taking medications that can reduce the level of potassium in the blood. Particular caution is also required in patients with risk factors for arrhythmia (eg in patients with acute myocardial ischemia or QT prolongation). In these patients the risk of life-threatening arrhythmias increasestorsade de pointes
and cardiac arrest. Prolongation of the QT interval may increase with increasing moxifloxacin concentrations. Before starting treatment, the physician, in each case individually, will consider the risk-benefit ratio and will decide if the treatment can be carried out. If you experience heart rhythm disturbances, please consult your doctor immediately.
The use of the preparation may be associated with the occurrence of fulminant hepatitis, sometimes fatal. If you experience symptoms such as progressive weakness of the body connected with jaundice, dark urine, bleeding tendencies or disturbances of consciousness, you should immediately consult a doctor (before the next dose). Your doctor will advise you to carry out appropriate check-ups.
If changes occur on the skin or mucous membranes, consult a physician immediately before using the next dose. In individual cases, the use of the preparation may be associated with severe skin lesions, including Stevens and Johnson syndrome, and toxic epidermal necrolysis. These changes can be life-threatening.
Quinolones can cause seizures. Particular care should be taken in people who are at increased risk of seizures. These are, in particular, people with central nervous system disorders (eg after a history of craniocerebral trauma, stroke, inflammation within the central nervous system) and people taking drugs that increase the risk of seizures (medicines that lower the seizure threshold, such as fenbufen and non-steroidal anti-inflammatory drugs, theophylline). Patients using moxifloxacin in parallel and the above-mentioned drugs are more likely to experience seizures.
Quinolones can cause sensory and sensory-motor neuropathies. If you experience sensory disturbances such as: pain, burning sensation, tingling, numbness or weakness, please consult your doctor before taking the next dose, as these symptoms may be signs of developing neuropathy.
If diarrhea occurs during or after treatment, do not treat it yourself, but consult a physician. There is a risk of pseudomembranous colitis, sometimes with a serious, life-threatening course. Its clinical symptoms (such as watery stools with blood and mucus, blunt, spilled or colic stomach ache, fever, periodic pressure on the stool) are caused by the wormClostridium difficile
, which can multiply in the conditions of disturbance of the normal bacterial flora in the gut. The use of drugs that inhibit intestinal motility is contraindicated in this case. If necessary, the doctor will apply appropriate pharmacological treatment.
Quinolones, including moxifloxacin, may exacerbate symptoms in patients with myasthenia gravis. Be careful.
The preparation, like other fluoroquinolones, increases the risk of inflammation and sometimes tendon rupture (cases of Achilles tendon rupture). This is particularly true for the elderly and people who use corticosteroid
s in parallel. If painful swelling or inflammation of the tendons appears, avoid physical exercise and consult a physician. Your doctor may advise you to stop taking the medicine and continue treatment with another antibiotic.
In elderly patients with impaired renal function it is necessary to be cautious and ensure adequate hydration of the body. Dehydration increases the risk of renal failure.
If visual disturbances occur (or other eye changes), consult an ophthalmologist immediately.
Due to the risk of hypersensitivity reactions to light during the treatment period, exposure to sunlight and UV (including sunbeds) should be avoided.
The use of the preparation for persons with a deficiency of Glucose
-6-phosphate dehydrogenase is possible only after the physician, in each individual case, assesses the risk-benefit ratio. These people have a risk of hemolysis (irreversible damage to the blood cells). If the preparation is used in these people, care should be taken to check for signs of hemolysis (usually the doctor will prescribe appropriate laboratory tests).
In the case of complicated infections of pelvic organs, the use of the preparation is not recommended.
For the treatment of pelvic organ infections, the doctor will usually use combination therapy with other antibiotics. If no improvement occurs within 3 days, you will probably need to change your treatment.
The product is not recommended for infections caused by multiresistant staphylococcus aureus.
Even after the first administration of drugs in this group, mental reactions may occur. In very rare cases, depression or psychotic reactions can lead to suicidal thoughts and auto-aggressive behaviors, such as suicide attempts. Administering the drug to people who have experienced psychosis or mental illness in the past requires the doctor to take special care.
The efficacy of the preparation in the treatment of severe inflammatory infections, fasciitis and diabetic foot infections with osteomyelitis has not been established.
The use of the preparation may interfere with the examination performed for detectionMycobacterium spp
. inhibiting the growth of mycobacteria and causing false negative results of culture of samples.
Additional information about the other ingredients of the preparation:
the preparation contains lactose; people with galactose intolerance, lactase deficiency or malabsorption of glucose-galactose should not use this preparation.
Does this preparation affect the ability to drive vehicles?
The preparation may cause central nervous system symptoms such as dizziness, severe temporary loss of vision, sudden loss of consciousness that may impair your ability to drive or use machines / machines. The occurrence of the above-mentioned side effects may be a threat in situations requiring psycho-motor skills. Check the body's reaction before driving or operating machinery / equipment.
Dosage of Avelox
The preparation is in the form of coated tablets. It is intended for oral use. Use the product as directed by your doctor. Do not exceed the recommended doses because it will not increase the effectiveness of the drug and may harm your health and life. If you have any doubts regarding the use of the preparation, consult a physician. In certain special patient groups, additional dosage adjustment is necessary.
Usually 400 mg once daily is used.
In patients with impaired renal function and in patients undergoing dialysis no dose adjustment is necessary.
Clinical data on the use of the preparation in patients with hepatic insufficiency are insufficient.
No dosage adjustment is necessary for the elderly or those with low body weight.
The use of the preparation in children and adolescents up to 18 years of age is contraindicated.
Method of administration:
The tablets should be swallowed whole, without chewing, with liquid. Can be taken with or without food.
The duration of treatment will be determined by a doctor (usually 5-10 days, in some cases 14 days).
Can I use Avelox during pregnancy and breastfeeding?
During pregnancy, do not use any medicine without consulting your doctor!
It is very important that before using any medicine during pregnancy or breastfeeding, consult a physician and explain beyond any doubt the potential risks and benefits associated with the use of the drug.If you are pregnant or plan to become pregnant, please inform the doctor prescribing the prescription for this medicine.
The preparation is contraindicated during pregnancy and breast-feeding.
Can I use other preparations in parallel?
Tell your doctor about all medicines you have recently taken, including those that are over the counter. In particular, inform your doctor if you use:
· Drugs that may prolong the ECG QT interval (some anti-arrhythmic drugs, tricyclic antidepressants, neuroleptics, macrolides, some antihistamines)
· Antacids containing iron, Magnesium
, aluminum, Calcium
· Anticoagulants (coumarin derivatives eg Warfarin
· Medicines that can reduce potassium levels [e.g. loop and thiazide diuretics, laxatives and rectal infusions (high doses), corticosteroids, amphotericin B] or medications that are associated with the occurrence of clinically significant bradycardia.
Contraindications are contraindicated if drugs that may prolong the QT interval (some anti-arrhythmic drugs: quinidine, disopyramide, Amiodarone
, sotalol, tricyclic antidepressants, some macrolide antibiotics: intravenous Erythromycin
, neuroleptics: phenothiazines, Haloperidol
, sultopride, antimalarial drugs are contraindicated) especially halofantrine, some antihistamines: terfenadine, astemizole, mizolastine, others: cisapride, vincammine, bepridil).
The concurrent use of moxifloxacin with antacids containing iron, magnesium, aluminum, calcium or zinc and with sucralfate or didanosine reduces the absorption of oral moxifloxacin. Therefore, a 6-hour interval should be maintained between taking these drugs and moxifloxacin. Do not take active charcoal because it significantly reduces the absorption of moxifloxacin. Quinolones may increase the effect of anticoagulants (eg warfarin); in the case of parallel use of these drugs, regular monitoring of blood coagulation parameters is recommended (if necessary, the doctor may adjust the dosage of anticoagulants). The preparation may increase the concentration or increase the effect of glibenclamide (although no clinically significant interaction has been observed, the risk of slight and transient hypoglycaemia can not be excluded).
What side effects can occur?
Like all medicines, Avelox can cause side effects, although they will not occur in all patients who use this medicine. Remember that the expected benefits of using the drug are usually greater than the damage resulting from the occurrence of side effects.
The frequent or not very frequent side effects that may occur after the use of the preparation include: headache and dizziness, nausea, vomiting, diarrhea, abdominal pain, lack of appetite, indigestion, constipation, bloating, gastritis, superinfection with resistant bacteria or fungi (e.g. yeast), increased liver enzymes and increased bilirubin in the blood, prolonged QT interval in the ECG, especially in patients with hypokalemia, palpitations, increased heart rate (tachycardia), angina pectoris, arrhythmia, dyspnoea (including asthmatic), agitation, anxiety reactions, increased psychomotor activity, confusion, anxiety, sleep disorders (drowsiness, insomnia), paresthesia, tremors, disturbances of taste, blurred vision (blurred vision), muscle and joint pain, feeling unwell, excessive sweating weakness, sometimes ob river. Uncommon haematological disorders (thrombocytopenia, anemia, leukopenia / neutropenia [reduced number of leukocytes / neutrophils], eosinophilia, prolonged prothrombin time). Very rarely agranulocytosis [significant granulocyte deficiency], increased prothrombin concentration, changes in blood clotting. Rare emotional instability, depression, hallucinations, life threatening behaviors, occasionally possible suicide attempts, psychotic reactions. Rare olfaction, abnormal movement coordination, seizures, epileptic seizures, speech and memory disorders. Rarely hearing impairment, tinnitus, total loss of hearing.Rarely short-term loss of consciousness, arrhythmia, hypertension / hypotension, occasionally rhythm torsade de pointes,
cardiac arrest. Rarely, intestinal inflammation may occur and very rarely pseudomembranous enteritis (manifested by severe persistent or bloody diarrhea during or after treatment), the course of which may be life-threatening. Rarely hepatitis, jaundice, very rare fulminant hepatitis that can lead to death. Rarely impaired renal function (increased creatinine and urea), renal failure. Uncommon rash, pruritus, urticaria, dry skin. The rare but serious life-threatening side effects include hypersensitivity reactions of the anaphylactic type: angioneurotic edema
(swelling of the mouth, tongue, throat impeding breathing) and anaphylactic shock. Very rarely severe skin reactions Stevens and Johnson syndrome, toxic epidermal necrolysis. Severe skin reactions and Anaphylactic reactions
may occur even after the first dose of the drug. Rarely possible: muscle weakness, muscle and joint pain, muscle stiffness, inflammation and tendon rupture (mainly Achilles tendon), worsening of myasthenia gravis.
Other preparations on the Polish market containing moxifloxacin
Floxamic (eye drops, solution)
Floxamic Neo (eye drops, solution)
Floxitrat (coated tablets)
Floxitrat Ofta (eye drops, solution)
Moloxin (coated tablets)
Monafox (eye drops, solution)
Moxinea (coated tablets)
Vigamox (eye drops, solution)