|The name of the preparation
||Character; dose; package
||Price after refund
||In which pharmacy?
||powder for solution for infusion;
||PharmaSwiss / Valeant
|| b / d
Note: reimbursed drug prices are in line with the regulations in force from July 1, 2018.
The preparation contains the substance:acyclovir
What is Aciclovir Jelfa?
An antiviral drug for general use.
What does Aciclovir Jelfa contain and how does it work?
The active substance is Acyclovir
, a synthetic medicine with antiviral activity. Effective against herpes simplex virus type 1 and 2 and varicella zoster virus. In virus-infected cells with viral enzymes, aciclovir is converted to a nucleotide analogue molecule, a chemical compound necessary for the synthesis of nucleic acid. The chemical similarity makes the modified acyclovir substitute for the actual nucleotide of the virus, disrupting the synthesis of viral DNA. As a consequence, the multiplication of viruses is inhibited. After intravenous administration, the Biol
ogical half-life of aciclovir is approximately 3 hours in adults and extends to approximately 19 hours in patients with chronic renal dysfunction. Aciclovir penetrates the organs, reaching a significant concentration in the liver, kidneys, muscles and lungs. The concentration of aciclovir in the cerebrospinal fluid reaches up to 50% of the plasma concentration. Acyclovir is excreted in human breast milk.
When to use Aciclovir Jelfa?
The preparation is indicated:
· In the treatment of skin and mucous membrane infections caused by herpes simplex virus and their recurrence in immunocompromised patients
· In the treatment of infections caused by varicella zoster in immunocompromised patients
· In the treatment of herpetic meningitis in patients after six months of age
· In the treatment of the initial herpetic stage of genital infection of severe clinical course.
When not to use this preparation?
Unfortunately, even if there are indications to use the preparation, it can not always be used. You can not use the product if you are allergic (you are hypersensitive) to any of the other ingredients or to valacyclovir.
When should you take extra care when using Aciclovir Jelfa?
Certain diseases and other circumstances may constitute a contraindication to use or indication to change the dosage of the preparation. In some situations it may be necessary to carry out specific check-ups.
The product is intended for intravenous use only, as a slow intravenous infusion. Do not give it in a quick intravenous injection, because it could damage the kidneys. It must not be used orally, subcutaneously or intramuscularly. If accidental contact of the preparation with the skin or mucous membranes occurs, this area should be cleaned with soap and water. If the preparation comes into contact with eyes, wash them thoroughly with plenty of water.
People should be treated with caution in patients with renal insufficiency and in the elderly. In these groups, there is an increased risk of nerve-related side effects. In people with renal insufficiency it is necessary to adjust the dosage by the doctor. In elderly people, renal dysfunction often occurs, therefore in this group of patients, if necessary, the doctor will recommend a corr
esponding reduction in dosage.
Particular care should be taken when using high doses of the preparation, the patient is dehydrated or takes other medicines that can damage the kidneys. Ensure adequate fluid supply and hydration. This will reduce the risk of kidney damage. During the treatment period, you should be carefully monitored.
Particular caution requires the use of the preparation in people who had prior treatment associated with neurological disorders. An increased risk of these disorders also exists in patients with renal, hepatic, electrolyte abnormal, hypoxic or parallel Methotrexate
In patients after bone marrow transplants or in patients with significant immune deficiencies, the effectiveness of the preparation may be reduced.
Does this preparation affect the ability to drive vehicles?
During the period of treatment, numerous disorders of the central nervous system may occur, including convulsions, agitation, and disturbances in consciousness. Such symptoms interfere with psychophysical fitness and make it impossible to drive vehicles and operate equipment / machines.
Dosage of Aciclovir Jelfa
The preparation is a powder for solution for infusion. It is intended for intravenous use only. It must not be used orally. The doctor will select the appropriate dosage and determine the duration of treatment depending on the severity and type of infection. Treatment should be started as soon as possible after diagnosis. If you have any doubts regarding the use of the preparation, consult a physician. In certain special patient groups, additional dosage adjustment is necessary. The preparation can be used only during closed treatment (treatment in hospital wards).
Skin and mucous membrane infections caused by herpes simplex virus in immunocompromised patients and herpetic genital infections of severe clinical course: 5 mg / kg body weight every 8 hours.
Immunodeficient patients infected with varicella zoster virus and those with herpetic meningitis receive 10 mg / kg body weight every 8 hours.
Children from 6 months of age-12. age:
Infections of the skin and mucous membranes caused by herpes simplex virus in immunocompromised patients and herpetic genital infections of severe clinical course: 250 mg / m2 body surface every 8 hours.
Immunodeficient children infected with varicella zoster virus and children suffering from herpetic meningitis receive 500 mg / m2 body surface every 8 hours.
Special groups of patients:
In patients with impaired renal function it is necessary to be cautious (constant control of creatinine clearance or its serum concentration is necessary) and maintenance of the proper hydration status of the body. Your doctor will reduce the dosage accordingly depending on your creatinine clearance.
If a patient undergoes hemodialysis, it is necessary to give a properly selected dose after each dialysis.
In the elderly, the doctor will consider the possibility of renal dysfunction and, if necessary, adjust the dose accordingly. The condition of proper hydration should be maintained.
The duration of treatment will be determined by the doctor (usually 5-10 days).
Method of administration:
The preparation can only be given as an infusion into a vein. The required dose is given as a slow intravenous infusion lasting at least 60 minutes.
Can I use Aciclovir Jelfa during pregnancy and breastfeeding?
During pregnancy, do not use any medicine without consulting your doctor!
It is very important that before using any medicine during pregnancy or breastfeeding, consult a physician and explain beyond any doubt the potential risks and benefits associated with the use of the drug. If you are pregnant or plan to become pregnant, please inform the doctor prescribing the prescription for this medicine.
Avoid using the product during pregnancy unless the doctor considers it absolutely necessary and in his opinion the expected benefits for the mother outweigh the potential risk to the fetus. Only a doctor can assess the risk-benefit ratio in your case.
Aciclovir is excreted in the milk of a nursing woman.If it is necessary to use the product during breastfeeding it is recommended to stop feeding.
Can I use other preparations in parallel?
Tell your doctor about all medicines you have recently taken, including those that are over the counter. In particular, please inform your doctor if you use:
· Probenecid (a medicine used to treat gout)
· Cimetidine (a medicine used in peptic ulcer disease)
· Tacrolimus, ciclosporin, mycophenolate mofetil (medicines used in people with transplants).
Caution should be exercised if the preparation is administered via intravenous infusions together with drugs that compete with it in the same excretion mechanism; there is a risk of increasing the concentration of these drugs in the blood.
Caution should be exercised (monitoring of renal function is necessary) if the preparation is administered intravenously in parallel with medicinal products that affect renal function (eg cyclosporine, tacrolimus).
There were no clinically relevant interactions of the preparation with other drugs.
What side effects can occur?
Like all medicines, Aciclovir Jelfa can cause side effects, although it will not occur in all patients who use this medicine. Remember that the expected benefits of using the drug are usually greater than the damage resulting from the occurrence of side effects.
The most common are: nausea, vomiting, transient elevation of liver enzymes, phlebitis, rash, photosensitivity, pruritus, urticaria, increased urea and creatinine in the blood. Uncommon haematological disorders (anemia, thrombocytopenia, decreased white blood cell count). Very rare: headaches and dizziness, drowsiness, confusion, psychosis, tremors, lack of mobility, speech disorders, hallucinations, coma, encephalopathy, dyspnoea, diarrhea, abdominal pain, hepatitis, jaundice, increased bilirubin, acute renal failure
, renal dysfunction (usually reversible after discontinuation of the drug and hydration of the patient), fatigue, fever, local inflammatory reactions, hypersensitivity and Anaphylactic reactions
: angioneurotic edema
and anaphylactic shock.
Other preparations on the Polish market containing acyclovir
Aciclovir Ziaja (cream)
Acix 250 (powder for solution for infusion)
Acix 500 (powder for solution for infusion)
Hascovir Control (tablets)
Hascovir Lipożel pro (gel)
Hascovir pro (cream)
Heviran (coated tablets)
Heviran Comfort (coated tablets)
Virolex (eye ointment)
Viru-POS (eye ointment)
Zovirax Intensive (cream)