► Aurorix (moklobemid) - Medycyna Praktyczna

Aurorix (moclobemide) - coated tablets

The name of the preparation Character; dose; package Manufacturer Price 100% Price after refund In which pharmacy?
Aurorix coated tablets; 150 mg; 30 tabl. MEDA Pharma 23.08 0.00
Aurorix coated tablets; 300 mg; 30 tabl. MEDA Pharma 46.00 0.00

Note: reimbursed drug prices are in line with the regulations in force from July 1, 2018.

The preparation contains the substance:moclobemide

The drug is available on prescription

What is Aurorix?

Antidepressant from the group of monoamine oxidase inhibitors.

What does Aurorix contain and how does it work?

The active substance of the preparation is moclobemide. The mechanism of its action is based on the selective and reversible blocking of an enzyme called monoamine oxidase type A. Its action is to disconnect the amino group from the molecule serotonin, noradrenaline and Dopamine . The antidepressant effect of the drug is related to the increase of the impulse transmission force by means of these relays. The effect of moclobemide is short-lived and is about 24 hours maximum. The effect achieved does not depend on the image and severity of depression, the length of the depressive phase and current treatment. Relatively better results are obtained in patients who have had more depressive phases.

When should I use Aurorix?

The preparation is indicated for the treatment of:
· Depressive syndromes
· Social phobia.

When not to use this preparation?

Unfortunately, even if there are indications to use the preparation, it can not always be used. You can not use the preparation if you are allergic (you are hypersensitive) to any of the ingredients.
Contraindications to the use of the preparation are also:
· Acute confusion
· Pheochromocytoma
· Parallel use of: selegiline, pethidine, dextromethorphan, selective serotonin reuptake inhibitors (SSRIs), monoamine oxidase inhibitors (MAOs), tricyclic antidepressants; after stopping treatment with serotonin reuptake inhibitors, and before starting treatment with moclobemide, it is necessary to maintain a gap of 4-5 periods of Biol ogical half-life of the drug or its active metabolite (usually taken 14 days)

The preparation should not be used in children and adolescents up to 18 years of age.

Take special care with Aurorix?

Certain diseases and other circumstances may constitute a contraindication to use or indication to change the dosage of the preparation. In some situations it may be necessary to carry out specific check-ups.
Depression is associated with an increased risk of suicidal thoughts, self-injury and suicide (events related to suicide). The effects of the preparation may occur only after a few weeks of treatment, sometimes this time is longer. Patients should be under strict medical supervision until they recover.People who have suicide attempts or those who show a significant degree of suicidal tendency before starting treatment should be closely monitored by a doctor. Also, during the change of dosage, the patient should be covered by special medical care. Patients and those around them should pay attention to any clinical sign of disease severity, suicidal behavior or thoughts or abnormal changes in behavior, and contact their physician immediately if they occur.
Patients with depression who are predominantly agitated in the clinical picture should not be treated with moclobemide or should be given only in combination with sedatives (eg benzodiazepine derivatives). Do not take any calming medication for more than 2-3 weeks.
When used to treat the depressive phase of bipolar disorder, the transition to the manic phase may occur.
Take special care in people:
· With hyperthyroidism due to the possibility of a rise in blood pressure
· With epilepsy
· With hypertension
· With hypersensitivity to thyrramine (they should not consume large amounts of tyramine during treatment).
To avoid relapse, the preparation should be discontinued gradually.
In people with liver failure, it is recommended to use 1 or 1/3 of the usual dose.
Moklobemide may exacerbate symptoms in patients with depression in schizophrenia or schizoaffective disorder; the use of moclobemide in this group of people is not recommended.
Hyponatremia may occur very rarely (usually in the elderly, probably due to the abnormal secretion of the antidiuretic hormone).
Preparations containing lactose should not be used in people with hereditary galactose intolerance, primary lactase deficiency or malabsorption of Glucose -galactose.
Does this preparation affect the ability to drive vehicles?
The use of moclobemide does not impede activities that require attention (eg driving a motor vehicle). However, special care should be taken in the initial period of treatment, due to possible individual reactions to the drug.

Dosage of Aurorix

The preparation is in the form of tablets. It is intended for oral use. Do not exceed the recommended doses because it will not increase the effectiveness of the drug and may harm your health and life. If you have any doubts regarding the use of the preparation, consult a physician.
Depressive syndromes.
Adults. Oral, initially 300 mg / day in 2 divided doses; your doctor may recommend increasing the dose after 7 days of use. The maximum dose is 600 mg / day in 2-3 divided doses. In some people, the dose can be reduced to 150 mg / day.
Social phobia.
Adults. Oral, initially 300 mg / day in 2 divided doses; your doctor may recommend increasing the dose after 21 days of use. The maximum dose is 600 mg / day in 2-3 divided doses. Treatment should be continued for 8-12 weeks.
Do not use the product too late in the evening. If the maintenance dose is 150 mg / day, you can take it once a day, in the morning.
In people with liver failure, it is recommended to use 1 or 1/3 of the usual dose.

Can you use Aurorix during pregnancy and breastfeeding?

During pregnancy, do not use any medicine without consulting your doctor!
It is very important to consult a physician before taking any medicine during pregnancy (and also during breastfeeding) and to explain beyond any doubt the potential risks and benefits of using the medicine. If you are pregnant or plan to become pregnant, please inform the doctor prescribing the prescription for this medicine.
The preparation can be used during pregnancy only in case of extreme necessity.
Do not use the product during breast-feeding.

Can I use other preparations in parallel?

Tell your doctor about all medicines you have recently taken, including those that are over the counter.
The use of selegiline, pethidine, dextromethorphan, selective serotonin reuptake inhibitors (SSRIs), monoamine oxidase inhibitors (MAOs) and tricyclic antidepressants is contraindicated.
The parallel use of:
· With sympathomimetic drugs (ephedrine, pseudoephedrine)
· With selective serotonergic receptor agonists (triptans) and within 14 days of discontinuation.
Caution should be used in parallel:
· Opioid analgesics; moclobemide increases their effect, it may be necessary to adjust the doses of both drugs
· Cimetidine; it will slow the metabolism of moclobemide, the doctor will probably recommend a half dose reduction of moclobemide
· Levodopa; there may be a hypertensive crisis
· Other drugs that increase serotonin levels (eg selective serotonin reuptake inhibitors, tricyclic antidepressants); there is the possibility of a serotonin syndrome
· Metoprolol ; moclobemide intensifies its antihypertensive effect
· Ibuprofen and other non-steroidal anti-inflammatory drugs (NSAIDs), moclobemide increases their effect, the doctor will probably recommend a reduction of the NSAID dose

You should not consume alcohol during treatment with moclobemide.
Because hypersensitivity to tyramine may occur during treatment, patients are advised to avoid eating large amounts of foods rich in it (chocolate, smoked meat and fish, cheese, soya products, yeast extract). It is recommended to take moclobemide after meals to reduce the likelihood of interaction with tyramine.

What side effects can occur?

Like all medicines, Aurorix can also cause side effects, although they will not occur in all patients who use this medicine. Remember that the expected benefits of using the drug are usually greater than the damage resulting from the occurrence of side effects.
The following side effects were seen: sleep disturbance, agitation, anxiety, anxiety, confusion, which resolved quickly after discontinuation of treatment.
She reported cases of suicidal thoughts and behavior during treatment with moclobemide, and also shortly after discontinuation of the drug.
dizziness, headache, paresthesia, irritability, dry mouth, nausea, diarrhea, constipation, vomiting, blurred vision, skin reactions such as rash, pruritus, urticaria, swelling, redness (especially on the face).
Rare cases of increased liver enzymes have been observed that did not cause clinical consequences.
In very rare cases, hyponatremia has been reported.

Other preparations on the Polish market containing moclobemide

Mobemid (coated tablets)
Moklar (coated tablets)