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► Atropinum Sulfuricum WZF 1% (atropine) - Medycyna Praktyczna

Atropinum Sulfuricum WZF 1% (atropine) - eye drops, solution

The name of the preparation Character; dose; package Manufacturer Price 100% Price after refund In which pharmacy?
Atropinum Sulfuricum WZF 1% eye drops, solution; 10 mg / ml; 5 ml Polfa Warsaw 15.51 4.96
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Note: reimbursed drug prices are in line with the regulations in force from July 1, 2018.

The preparation contains the substance:atropine

The drug is available on prescription

What is WZF Atropinum Sulfuricum?


A drug from the group of parasympatolytics applied topically to the eye (into the conjunctival sac) to dilate the pupil.

What contains and how does Atropinum Sulfuricum WZF work?

The active substance is atropine, an alkaloid found in plants belonging to the Solanaceae family (Solanaceae), including in wolfberry (Atropa belladonna). Atropine belongs to a group of medicines called parasympatolytics (another name used is anticholinergic drugs, cholinolytic drugs). The effect of cholinolytic drugs is to block the activation of cholinergic receptors located on the surface of nerve cells and target cells. The effects of atropine are muscarinic receptors, which are a subtype of cholinergic receptors. These are receptors stimulated in physiological conditions by acetylcholine. By acting on muscarinic receptors, atropine eliminates the action of acetylcholine and causes relaxation of the smooth muscle of the gastrointestinal tract, urinary tract, biliary tract and bronchi. It has an inhibitory effect on the secretion of most glands (except for milk), including sweat glands. It affects heart function by inhibiting the transmission of the vagus nerve. Modifying the activity of the sinoatrial node and atrio-ventricular node increases the frequency of the heart rhythm.
In the form of eye drops, atropine is applied to the conjunctival sac. Atropine has a relaxant effect on the pupil sphincter and the ciliary body muscle and causes pupil dilation. It strikes the accommodation of the eye.
After administration to the conjunctival sac, atropine is absorbed into the systemic circulation. Its metabolism occurs in the liver, excreted in small amounts in the form of metabolites and in unchanged form. Hydroxyethylcellulose, which is an auxiliary component of the formulation, gives the drops greater viscosity and causes longer persistence in the conjunctival sac, thus extending the duration of action.

When should I use Atropinum Sulfuricum WZF?

The preparation is indicated:
· For long-term pupil dilation, eye diagnostic tests and refraction testing in young children
· In the treatment of iritis and cilium inflammation to prevent iris-lenticular adhesions.

When not to use this preparation?

Unfortunately, even if there are indications to use the preparation, it can not always be used. You can not use the preparation if you are allergic (you are hypersensitive) to any of the ingredients or other cholinolytics.
You also can not use the product if you have primary glaucoma with the possibility of closing the angle of vision or glaucoma with a closed angle of perception.

When should you use extreme caution when using WZF Atropinum Sulfuricum?

Certain diseases and other circumstances may constitute a contraindication to use or indication to change the dosage of the preparation.In some situations it may be necessary to carry out specific check-ups.
The preparation is intended only for external application, locally to the conjunctival sac.
After applying the preparation, eyes should be protected from light.
Use of the preparation in infants, young children, pregnant women and the elderly requires caution as side effects may occur or worsen; patients from these groups should remain under careful medical observation.
In people over 60 years of age, pupil dilation may accelerate the onset of glaucoma (due to closing of the angle of perception).
Additional information about the other ingredients of the preparation:
· The preparation contains benzalkonium chloride as a preservative, which can accumulate in contact lenses and destroy them (cause discolorations); people who use contact lenses should remove them before instillation and wait at least 30 minutes before putting them back on again
· Benzalkonium chloride may cause eye irritation.

Does this preparation affect the ability to drive vehicles?
Do not drive or operate machines / machines during the period of application. The use of the preparation causes long-lasting visual disturbances (disturbances may persist up to 5-7 days after application).

Dosage of Atropinum Sulfuricum WZF

The preparation is in the form of eye drops. Use the product as directed by your doctor. Do not exceed the recommended doses because it will not increase the effectiveness of the drug and may harm your health and life. If you have any doubts regarding the use of the preparation, consult a physician.
For ophthalmologic tests, the dosage is determined by the doctor, usually the preparation is used as described below.
In the refractive examination of the eye in young children, topically to the conjunctival sac, after appropriate dilution of the 1% solution:
· Children up to 3 years of age - 0.25% solution: 1 drop 2 times a day for 5 days
· Children 3.-6. year of life - 0.5% solution: 1 drop 2 times a day for 5 days
· Children after the age of 6 years - 1% solution: 1 drop 2 times a day for 3 days.
An additional dose may be given by the doctor immediately before the ophthalmological examination.
For the treatment of iritis and iridocyclitis: 1 drop of 1% solution into the conjunctival sac up to 2 times a day.
To limit the systemic absorption of the active substance, it is recommended to compress the internal canthus angle for one minute, immediately after instillation. This is especially important in children.
Do not touch the surface of the eye or the eyelid or any other surface with the dropper tip, as this may contaminate the product and lead to eye infection. The infection can cause serious eye damage or blindness.

Can I use Atropinum Sulfuricum WZF during pregnancy and breastfeeding?

During pregnancy, do not use any medicine without consulting your doctor!
It is very important that before using any medicine during pregnancy or breastfeeding, consult a physician and explain beyond any doubt the potential risks and benefits associated with the use of the drug. If you are pregnant or plan to become pregnant, please inform the doctor prescribing the prescription for this medicine.
Use during pregnancy is only allowed if the doctor considers it absolutely necessary, and in his opinion the expected benefits outweigh the possible risks. Only a doctor can assess the benefit / risk ratio in your case.
It is not known whether atropine is excreted in human milk. Before using the preparation during breastfeeding, consult a doctor.

Can I use other preparations in parallel?

Tell your doctor about all medicines you have recently taken, including those that are over the counter.
The effect of the preparation may be exacerbated if other cholinolytics or drugs exhibiting a cholinolytic effect are used, eg Amitriptyline , hydroxyzine, Haloperidol , chlorpromazine, first generation antihistamines and some drugs used in Parkinson's disease.
The atropine contained in the preparation acts in opposition to cholinomimetics (physostigmine, neostigmine, pilocarpine). These preparations can put up with each other's effects.

What side effects can occur?

Like all medicines, Atropinum Sulfuricum WZF 1% may cause side effects, although they will not occur in all patients using this product. Remember that the expected benefits of using the drug are usually greater than the damage resulting from the occurrence of side effects.
Local eye / eye reactions such as visual and accommodation disturbances, increased intraocular pressure in people with closed angle of view, conjunctivitis, pruritus, eyelid edema, lacrimation, photosensitivity may occur.
In addition, systemic side effects may occur such as: balance disorders, behavioral disturbances, dizziness, increased heart rate, arrhythmias, fever, hallucinations (visual, auditory), rashes, bloating (in infants), severe thirst, dry membrane mucous oral cavity, drowsiness, fatigue, weakness, dry skin, urinary retention. There may also be: dermatitis (eczema), severe generalized reactions manifested by a decrease in blood pressure and worsening breathing disorders.

Other preparations on the Polish market containing atropine

Atropinum Sulfuricum WZF (solution for injection)