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► Atossa (ondansetron) - Medycyna Praktyczna

Atossa (ondansetron) - coated tablets

The name of the preparation Character; dose; package Manufacturer Price 100% Price after refund In which pharmacy?
ATOSS coated tablets; 8 mg; 10 tables EGIS 44.23 3.20
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Note: reimbursed drug prices are in line with the regulations in force from July 1, 2018.

The preparation contains the substance:ondansetron

The drug is available on prescription

What is Atossa?

The drug is used to prevent nausea and vomiting and to treat nausea and vomiting associated with Chemotherapy and radiotherapy for cancer or the post-operative period.

What does Atossa contain and how does it work?

The active substance of the preparation is ondansetron. Ondansetron is used in the prevention of nausea and vomiting and in their symptomatic treatment. Ondansetron limits the action of serotonin (another name for serotonin is 5-hydroxytryptamine, in short 5-HT) naturally occurring in the gastrointestinal tract, nervous system and in the platelets of substances with multiple effects, which may cause the gag reflex. Ondansetron selectively blocks 5-HT3 serotonin receptors located in the nerve cells of the central and peripheral nervous systems. In this way, it prevents the stimulation of these receptors by serotonin. Ionizing radiation (radiotherapy) and cytostatics (chemotherapy) can cause the release of serotonin in the small intestine, thus initiating the gag reflex as a consequence of stimulation of the 5-HT3 serotonin 5-HT3 vagus nerve fibers. Stimulating the vagus nerve can also trigger central excitation leading to vomiting. Ondansetron inhibits the formation of the gag reflex. After oral administration, ondansetron is rapidly and completely absorbed from the gastrointestinal tract. The maximum blood concentration occurs after about 90 minutes after an oral 8 mg dose. After rectal administration (suppositories) the maximum concentration occurs after 6 hours, and after intramuscular administration after about 10 minutes. Ondansetron is metabolised in the liver; in subjects with severe hepatic impairment, the Biol ogical half-life of the drug is significantly prolonged and the bioavailability of forms absorbed from the gastrointestinal tract increases due to reduced metabolism during the first pass through the liver.

When to use Atossa?

The preparation is indicated:
· In the prevention of nausea and vomiting caused by cancer chemotherapy
· In the prevention of nausea and vomiting caused by radiotherapy
· In the prevention of nausea and vomiting of the perioperative period.

When not to use this preparation?

Unfortunately, even if there are indications to use the preparation, it can not always be used. You can not use the preparation if you are allergic (you are hypersensitive) to any of the ingredients.
The use of the preparation with apomorphine is contraindicated.

When should you exercise extreme caution when using Atoss?

Certain diseases and other circumstances may constitute a contraindication to use or indication to change the dosage of the preparation. In some situations it may be necessary to carry out specific check-ups.
In people with liver failure, it is necessary to adjust the dosage by the doctor; do not use a dose of more than 8 mg per day in these patients.
Caution should be exercised if the preparation is used in patients with gastrointestinal motility disorders. The preparation may affect the prolongation of intestinal transit time. After the preparation, patients with symptoms of subacute obstruction should remain under special observation.
If you have ever been suspected of being hypersensitive to other medicines with similar effects (other medicines blocking serotonin 5-HT3 receptors), please inform your doctor. In people who are allergic to other drugs in this group, the preparation may cause hypersensitivity reactions, sometimes severe. A harbinger of hypersensitivity reactions may be respiratory disorders that require adequate symptomatic treatment and special precautions.
The preparation is not effective in the case of nausea and vomiting associated with motion sickness.
Additional information about the other ingredients of the preparation:
the preparation contains lactose; people with galactose intolerance, lactase deficiency or malabsorption of Glucose -galactose should not use this preparation.

Does this preparation affect the ability to drive vehicles?
In the conducted tests, no effect of the preparation on psychomotor performance was found.

Dosage of Atossa

The preparation is in the form of coated tablets. Do not exceed the recommended doses because it will not increase the effectiveness of the drug and may harm your health and life. If you have any doubts regarding the use of the preparation, consult a physician.
In people with moderate or severe liver dysfunction, it is necessary to adjust the dosage by the doctor; do not use a dose of more than 8 mg per day in these patients.
Nausea and vomiting caused by chemotherapy:
Adults and children over 12 years of age: oral 8 mg twice daily. The first dose is taken 30 minutes before the start of chemotherapy, the dose is repeated after 8 hours, after which treatment is continued at 8 mg 2 times a day (every 12 hours) for 1-2 days after the end of chemotherapy.
Children 4-12. year of life: 4 mg 3 times a day. The first dose is taken 30 minutes before the start of chemotherapy, the dose is repeated after 4 and 8 hours, after which treatment is continued at doses of 4 mg 3 times a day (every 8 hours) for 1-2 days after the end of chemotherapy.
Children up to 4 years old: dosage has not been established.
Nausea and vomiting caused by radiotherapy:
Adults: 8 mg 3 times a day. In the case of whole body radiotherapy, 8 mg are taken 1-2 hours before each fraction of radiotherapy; in the case of a single abdominal radiotherapy [high dose fraction] 8 mg is taken 1-2 hours before radiotherapy, then every 8 hours; treatment is continued for 1-2 days after the end of radiotherapy; in the case of fractionated daily abdominal radiotherapy 8 mg is taken 1-2 hours before radiotherapy, then every 8 hours of radiotherapy each day.
Children: no data on the use of the preparation in children in this indication.
Prevention of nausea and vomiting of the perioperative period:
Adults: 16 mg 1 hour before anesthesia.
Children: no data on the use of the preparation in children in this indication.
In people with moderate or severe liver dysfunction, it is necessary to adjust the dosage by the doctor; do not use a dose of more than 8 mg per day in these patients.

Can Atossa be used during pregnancy and breastfeeding?

During pregnancy, do not use any medicine without consulting your doctor!
It is very important that before using any medicine during pregnancy or breastfeeding, consult a physician and explain beyond any doubt the potential risks and benefits associated with the use of the drug. If you are pregnant or plan to become pregnant, please inform the doctor prescribing the prescription for this medicine.
The preparation should not be used during pregnancy unless the physician considers the use of the preparation during this period to be strictly necessary.
Do not use the preparation during breastfeeding; ondansetron is excreted in breast milk.

Can I use other preparations in parallel?

Tell your doctor about all medicines you have recently taken, including those that are over the counter.
Drugs that potentiate the activity of the cytochrome P450 3A4 isoenzyme (eg, phenytoin, carbamazepine, rifampicin) may cause a reduction in the concentration of ondansetron in the blood.
Tramadol may increase the amount of ondansetron in the blood.
Application with apomorphine is contraindicated due to the risk of significant hypotension and unconsciousness.
Ondansetron does not affect the antitumor efficacy of chemotherapy drugs or interactions with other antiemetics.

What side effects can occur?

Like all medicines, Atossa can also cause side effects, although they will not occur in all patients who use this medicine. Remember that the expected benefits of using the drug are usually greater than the damage resulting from the occurrence of side effects.
Very often or frequently: headache, dizziness, calming, constipation, diarrhea, rash, itching, dry mouth, hiccups, feeling hot or flushing. Uncommon: increased liver enzymes, increased bilirubin. Rarely or very rarely: seizures, epileptic seizures, involuntary movements (including extrapyramidal system symptoms such as paroxysmal upward and / or dystonic symptoms), arrhythmias, chest pain sometimes with ST depression in the ECG, hypotension, reduced heart rate (bradycardia), hypersensitivity reactions, sometimes severe, including Anaphylactic reactions (angioneurotic edema, anaphylactic shock).

Other preparations on the Polish market containing ondansetron

Ondansetron Accord 2 mg / ml (solution for injection and infusion)
Ondansetron B. Braun 2 mg / ml (solution for injection)
Ondansetron Bluefish (orodispersible tablets)
Ondansetron Kabi (solution for injection)
Setronon (coated tablets)
Zofran (suppositories)
Zofran (syrup)
Zofran (coated tablets)
Zofran (solution for injection)
Zofran Zydis (oral lyophilisate)