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► Aspirin Cardio (acetylsalicylic acid) - Practical Medicine

Aspirin Cardio (acetylsalicylic acid) - coated tablets

The name of the preparation Character; dose; package Manufacturer Price 100% Price after refund In which pharmacy?
Aspirin Cardio coated tablets; 100 mg; 28 tabl. bayer 9.49 Check

Note: reimbursed drug prices are in line with the regulations in force from July 1, 2018.

The preparation contains the substance:acetylsalicylic acid

The drug is available without a prescription

What is Aspirin Cardio?

A preparation that inhibits platelet aggregation.

What does Aspirin Cardio contain and how does it work?

The active substance is a non-steroidal anti-inflammatory drug (NSAID) Acetylsalicylic acid . Like other NSAIDs , it has anti-inflammatory, analgesic, antipyretic and platelet aggregation inhibitors. The basis of the mechanism of action of acetylsalicylic acid is the inhibition of cyclooxygenases (both COX-1 and COX-2), enzymes involved in the synthesis of prostaglandins and thromboxane from lipids of cell membranes. Prostaglandins play a significant role in the development of inflammation, and thromboxane stimulates platelet aggregation and vasoconstriction (which may contribute to the formation of clots and congestion). Inhibition of increased prostaglandin synthesis underlies the analgesic and anti-inflammatory effects of acetylsalicylic acid, and the inhibition of thromboxane synthesis at the base of its antiaggregatory action.
Acetylsalicylic acid, used in low doses (usually 75-150 mg daily), inhibits platelet COX-1 activity. This leads to suppression of thromboxane synthesis, reduction of platelet aggregation ability and inhibition of vasodilator-dependent vasoconstriction. COX-1 activity is inhibited by acetylsalicylic acid irreversibly and persists throughout the life of the platelet, i.e. about 9 days. Analgesic and anti-inflammatory effects, dependent on inhibition of COX-2 induced inflammation, require higher doses of acetylsalicylic acid (usually 2-6 g per day).
The rate of absorption of acetylsalicylic acid from the gastrointestinal tract depends on the pharmaceutical form used. Acetylsalicylic acid found in enteric coated tablets is absorbed more slowly than from tablets disintegrating in the stomach. The release of the active substance from coated tablets takes place only in the small intestine, which contributes to the protection of the gastric mucosa against the irritating effect of acetylsalicylic acid.

When should I use Aspirin Cardio?

The preparation is indicated for use in the following cardiovascular diseases:
· In unstable ischemic heart disease
· If you have a recent heart attack or if you have a suspicion
· To prevent a second heart attack
· In the prevention of thromboembolic complications after surgical or intervention on vessels (eg coronary artery bypass grafting, percutaneous transluminal coronary angioplasty, carotid endarterectomy, arteriovenous anastomosis)
· In the prevention of attacks of transient ischemia (TIA) and ischemic stroke in patients with TIA
· In the prevention of first myocardial infarction in patients with multiple risk factors
· In the prevention of deep vein thrombosis and pulmonary embolism in long-term immobilized patients (eg after major surgery) as a supplement to other methods of prophylaxis.

When not to use this preparation?

Unfortunately, even if there are indications to use the preparation, it can not always be used. You can not use the preparation if you are allergic (you are hypersensitive) to any of the ingredients or other salicylates.
It is contraindicated if you have ever had asthma attacks (so-called aspirin-induced asthma) after taking salicylates or non-steroidal anti-inflammatory drugs (eg Ibuprofen , Ketoprofen , Naproxen ).
The use of the preparation is contraindicated in people:
· With an increased risk of bleeding (haemorrhagic diathesis)
· With active peptic ulcer of the stomach and / or duodenum
· With severe liver or kidney failure
· With severe heart failure
· Taking Methotrexate in doses of 15 mg in a week or more in parallel
and
· In women in the third trimester of pregnancy
· In children up to 12 years of age, especially in the course of viral infections (eg influenza, chickenpox), due to the risk of Reye's syndrome, a severe condition leading to liver and brain damage that may be life-threatening.

Take special care with Aspirin Cardio?

Certain diseases and other circumstances may constitute a contraindication to use or indication to change the dosage of the preparation. In some situations it may be necessary to carry out specific check-ups.
Caution should be exercised if acetylsalicylic acid is used in people:
· With hypersensitivity to non-steroidal anti-inflammatory and anti-rheumatic drugs or to any allergens
· Using anticoagulants in parallel
· Using ibuprofen (risk of reducing acetylsalicylic acid inhibiting platelet aggregation); before the combined use of ibuprofen and acetylsalicylic acid, a doctor should be consulted
· With impaired renal or cardiovascular function (eg renal vascular disease, congestive heart failure, decreased intravascular volume, major surgical procedures, sepsis or haemorrhagic events), because acetylsalicylic acid may increase the risk of kidney damage and acute renal failure
· With liver problems
· With a history of peptic ulceration or Gastrointestinal bleeding (risk of ulcer recurrence and gastrointestinal bleeding)
· Deficient in Glucose -6-phosphate dehydrogenase (risk of haemolysis of red blood cells).
If you suspect or have been diagnosed with any of the above conditions, consult a physician before using the preparation.
Using acetylsalicylic acid may cause an asthma attack, bronchospasm causing difficulty in breathing or other hypersensitivity reactions. Increased risk includes patients with bronchial asthma, also if it has occurred in the past, patients with rhinitis, nasal polyps, chronic respiratory diseases, and people who have allergic reactions to any allergens (eg skin reactions, pruritus, urticaria).
The preparation may cause prolongation of bleeding time, including during or after surgery (this also applies to minor surgical procedures, eg tooth extraction). Before the planned surgery, you should consult a doctor, because it is usually necessary to discontinue use a few days before the procedure.
Acetylsalicylic acid, even when used in small doses, inhibits the excretion of uric acid. In patients with reduced uric acid excretion, the preparation may cause gout attack.
Do not use in children or adolescents in the course of viral infections (eg, influenza, chickenpox), because of the risk of Reye's syndrome, a serious condition leading to liver and brain damage that may be life-threatening. Persistent vomiting occurring during the course of viral diseases may indicate the occurrence of Reye's syndrome.

Does this preparation affect the ability to drive vehicles?
There was no effect of the preparation on the ability to drive vehicles and operate equipment / machines.

Dosage of Aspirin Cardio

The preparation is in the form of coated tablets. It is intended for oral use. Use the preparation as recommended. Do not exceed the recommended doses, because it will not increase the effectiveness of the drug and may harm your health and life. If you have any doubts about the use of the preparation, consult your doctor.
Usually 100 mg once daily.
Fresh myocardial infarction or suspicion: an initial loading dose of 200-300 mg once a day, tablets should be broken down for quicker absorption.
Prevention of deep vein thrombosis and pulmonary embolism in long-term immobilized patients, in addition to other prophylaxis methods: 100-200 mg once daily.
Do not use in children under 12 years of age.
Application method:
The preparation is intended for oral use. The tablets should be taken after a meal, swallowed whole (do not break, do not chew), with plenty of liquid.
Warning! In fresh myocardial infarction or suspicion, the enteric preparation should be thoroughly broken down to obtain rapid absorption of the active substance.

Can Aspirin Cardio be used during pregnancy and breastfeeding?

During pregnancy, do not use any medicine without consulting your doctor!
It is very important that before using any medicine during pregnancy or breastfeeding, consult a physician and explain beyond any doubt the potential risks and benefits associated with the use of the drug. If you are pregnant or plan to become pregnant, consult a physician before using the product.
The use of the preparation is contraindicated in women in the third trimester of pregnancy.
The preparation should not be used in the first and second trimester of pregnancy, unless the doctor considers it absolutely necessary. The use of the preparation in the first and second trimester of pregnancy and in women planning pregnancy is allowed only on the order of a physician, if he considers the use necessary after considering whether the expected benefits to the mother outweigh the possible risk to the fetus (only short-term use of small doses). Only a doctor can assess the benefit / risk ratio in your case.
Before using the product during breastfeeding, consult a doctor (your doctor may allow short-term use of salicylates at low doses during this period). If you regularly take high doses of acetylsalicylic acid, breast-feeding should be stopped earlier.

Can I use other preparations in parallel?

Tell your doctor about all medicines you have recently taken, including those that are over the counter.
Concomitant use of acetylsalicylic acid and methotrexate at doses of 15 mg per week or more is contra-indicated (possible increase in methotrexate concentration and increased bone marrow toxicity, sometimes severe intoxication leading to death).
If you are using any of the medicines listed below, consult your doctor before using the product because you may need to change your dosage or stop taking your medicine. Take particular care if you are using:
· Methotrexate at doses lower than 15 mg per week (possible increase in methotrexate concentration and increased bone marrow toxicity, if a physician recommends using acetylsalicylic acid in parallel, blood counts should be monitored once a week during the first weeks of treatment; renal and elderly patients require regular medical examinations and supervision)
· Ibuprofen (possible reduction of platelet aggregation inhibiting the effects of acetylsalicylic acid in small doses)
· Anticoagulants such as Warfarin , Heparin (possible increase in anticoagulant effect and prolonged bleeding time, increased risk of haemorrhage)
· Selective serotonin reuptake inhibitors (increased risk of gastrointestinal bleeding)
· Other non-steroidal anti-inflammatory drugs and salicylates, in doses of 3g per day or more (increased risk of side effects, especially stomach ulcer and / or duodenum, gastrointestinal bleeding and kidney damage)
· Drugs that increase uric acid excretion in the urine, eg benzbromarone, probenecid (acetylsalicylic acid used together with drugs increasing the excretion of uric acid, causes the weakening of the action of these drugs, in patients with reduced uric acid excretion the preparation may cause gout attack)
· Cardiac glycosides, e.g. Digoxin (the risk of increasing the concentration of cardiac glycosides in the blood, monitoring of the concentration of digoxin in the blood plasma is recommended)
· Antidiabetic medicines, e.g. insulin , sulphonylureas (increased severity, risk of hypoglycaemia)
· Thrombolytic drugs and platelet aggregation inhibitors such as ticlopidine, Clopidogrel (possible worsening of their effect, prolonged bleeding time and increased risk of haemorrhage)
· Diuretics (possible reduction of diuretic and antihypertensive effect, risk of acute renal failure - hydration is recommended and monitoring of renal function at the beginning of treatment, possible increase in the toxicity of Furosemide to the hearing organ)
· Antihypertensive agents, including angiotensin converting enzyme inhibitors, angiotensin antagonists, and beta blockers (possible reduction of antihypertensive effect, risk of acute renal failure)
· corticosteroid s used generally, with the exception of Hydrocortisone used as a replacement therapy in Addison's disease (use with acetylsalicylic acid increases the risk of stomach ulcer and / or duodenum and gastrointestinal bleeding)
· Valproic acid (possible increase in its toxicity and aggravation of platelet aggregation inhibition).
Alcohol consumption increases the risk of gastrointestinal adverse reactions, including gastrointestinal bleeding.

What side effects can occur?

Like all medicines, Aspirin Cardio can cause side effects, although they will not occur in all patients who use this medicine. Remember that the expected benefits of using the drug are usually greater than the damage resulting from the occurrence of side effects.
Gastrointestinal side effects may occur, including nausea, vomiting, indigestion and abdominal pain. Rare: gastritis, gastrointestinal bleeding (including tarry stools, bloody vomiting) and gastric and / or duodenal ulcer, sometimes with bleeding and perforation, increased liver enzymes, transient liver dysfunction, hypoglycaemia. Possible: headache and dizziness, tinnitus, renal dysfunction (after prolonged use of high doses of acetylsalicylic acid may occur renal papillary necrosis and interstitial nephritis), prolonged bleeding time and increased risk of bleeding (perioperative hemorrhage, hematomas, bleeding from the nose, bleeding from the urogenital tract, bleeding from the gums, gastrointestinal haemorrhage, cerebral haemorrhage, especially in people with uncontrolled hypertension and / or taking haemostatic agents in parallel). In some cases, haemorrhage can be life-threatening; they can also lead to acute or chronic anemia (also as a result of latent microcortes from the gastrointestinal tract) with appropriate symptoms, such as weakness, paleness, and reduced blood supply to organs and tissues. Hypersensitivity reactions (rash, urticaria, pruritus) and Anaphylactic reactions may occur, including life threatening anaphylactic shock, angioneurotic edema (swelling of the face, larynx, tongue, throat that may impede breathing), bronchospasm, asthma attack and severe skin reactions.
Prolonged intake of medicines containing acetylsalicylic acid may cause a headache that worsens when taking subsequent doses. Prolonged intake of analgesics may lead to severe renal dysfunction and renal failure. In patients with severe deficiency of glucose-6-phosphate dehydrogenase, haemolysis or haemolytic anemia may occur.

Other preparations on the Polish market containing acetylsalicylic acid

Abrea (enteric-coated tablets)
Acard (enteric-coated tablets)
Acard 150 mg (enteric-coated tablets)
Acard 300 mg (tablets)
Acesan (tablets)
Alepton (enteric-coated tablets)
Alka-Prim (effervescent tablets)
Alka-Seltzer (effervescent tablets)
Anacard medica protect (enteric-coated tablets)
Aspifox (enteric-coated tablets)
Aspirin (tablets)
Aspirin Effect (granules)
Aspirin Pro (coated tablets)
Aspirin Ultra Fast (effervescent tablets)
Cardiopirin (enteric-coated tablets)
Encopirin (enteric-coated tablets)
Encopirin Cardio 81 (enteric-coated tablets)
Gripblocker (tablets)
Hascopiryn cardio (enteric-coated tablets)
Lecardi (gastro-resistant tablets)
Maxipirin (tablets)
Polocard (enteric-coated tablets)
Polopiryna Max (enteric-coated tablets)
Polopyrine S (tablets)
Proficar (enteric-coated tablets)
Pyramidon fast (oral powder)