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► Arteoptic (carteolol (cardolole hydrochloride)) - Practical Medicine

Arteoptic (carteolol (karteolol hydrochloride)) - eye drops, solution

The name of the preparation Character; dose; package Manufacturer Price 100% Price after refund In which pharmacy?
Arteoptic eye drops, solution; 20 mg / ml; 5 ml Laboratoires Thea 28.49 Check

Note: reimbursed drug prices are in line with the regulations in force from July 1, 2018.

The preparation contains the substance:karteolol (cardolole hydrochloride)

The drug is available on prescription

What is Arteoptic?

A drug from the beta-blocker group applied topically to the eye (into the conjunctival sac).

What does Arteoptic contain and how does it work?

The active substance is Karteolol. It is a substance belonging to a group of medicines called beta-blockers (another name is beta-blockers). These drugs work by blocking certain types of receptors, called beta adrenergic receptors. These are receptors stimulated in physiological conditions by adrenaline or noradrenaline released after the activation of the sympathetic nervous system. Pharmacological blocking of receptors prevents them from being stimulated, thereby reducing the effects of adrenaline or noradrenaline on target tissues with beta receptors. Preparations from this group are mainly used as antihypertensive drugs and in the course of cardiovascular diseases. In the form of eye drops, the cardeolol is applied topically to the conjunctival sac, where it lowers the intraocular pressure probably by reducing the production of aqueous humor. In addition, karteolol increases the blood flow in the eye (perfusion). It does not cause pupil constriction.
From the conjunctival sac, karteolol penetrates the Corn ea well, resulting in a high concentration in the structures of the eye. It can be absorbed into the bloodstream and cause systemic side effects. The maximum concentration in ocular tissues is obtained within 30-60 minutes after topical application to the eye.

When to use Arteoptic?

The preparation is indicated to reduce intraocular pressure in people:
· With open-angle, chronic, open-angle glaucoma
· With ocular hypertension.

When not to use this preparation?

Unfortunately, even if there are indications to use the preparation, it can not always be used. You can not use the preparation if you are allergic (you are hypersensitive) to any of the ingredients.
You can not use the preparation if you are present:
· Sinus bradycardia
· A sick sinus node syndrome
· Sinoatrial block
· 2nd or 3rd degree atrioventricular block in patients without a pacemaker
· Cardiogenic shock
· Symptomatic heart failure
· Bronchial asthma (also seen in the past) or severe chronic obstructive pulmonary disease and other reactive respiratory diseases.

When should you exercise extreme caution when using Arteoptic?

Certain diseases and other circumstances may constitute a contraindication to use or indication to change the dosage of the preparation. In some situations it may be necessary to carry out specific check-ups.
The preparation is intended only for external application, locally to the conjunctival sac.
Beta-blockers applied topically (to the conjunctival sac) can be absorbed and cause systemic side effects that are characteristic of this group of drugs. To minimize the systemic absorption of the preparation, it is recommended to close the eyelid and press the Nasol abial duct for about 2 minutes after administration.
In people with heart disease (such asischemic heart disease, Prinzmetal vasospastic angina, heart failure) and in people with hypotension, the doctor will consider the possibility of another treatment. However, if the doctor recommends the use of the preparation, care should be taken and follow medical observation. In the event of side effects or worsening of symptoms of heart disease, you should immediately consult a doctor.
Caution should be exercised if the preparation is used in patients with a first degree heart block; the preparation may reduce the speed of the conduction of stimuli in the heart.
The use of the preparation in patients with peripheral circulation disorders (Raynaud's syndrome, intermittent claudication) or with an untreated phaeophilic adrenal tumor requires caution.
Administration of beta-blockers in the form of eye drops may occasionally result in an asthma attack or respiratory distress in patients with an increased risk of bronchospasm. Before starting the preparation in patients with mild to moderate chronic obstructive pulmonary disease, the physician will consider the benefit / risk ratio and will in each case individually decide whether to start treatment with the product. Caution should be exercised because the use of beta-blockers in this group of patients may result in increased resistance in the airways and respiratory distress syndrome.
Patients with diabetes and those at risk of hypoglycaemia (low blood Glucose ) should take special care because beta-blockers may mask the symptoms of hypoglycaemia, such as palpitations, increased heart rate (tachycardia) or sweating. You should monitor your blood glucose. The preparation may also mask symptoms of hyperthyroidism, including increased heart rate. Caution should be exercised in people suspected of hyperthyroidism, in particular, the use of beta-blockers should not be abruptly interrupted, as this could lead to increased tachycardia and thyroid crisis.
Use with caution in patients with metabolic acidosis or ketoacidosis.
In the case of corneal diseases, care should be taken because beta-blockers can cause dry eyes.
Caution should be used if the product is used in parallel with other systemic beta blockers due to the risk of increased activity and side effects, including serious cardiac adverse events. The patient should remain under medical surveillance.
The use of two locally active beta-blockers is not recommended.
Beta-blockers may increase sensitivity to allergens and increase hypersensitivity reactions (including Anaphylactic reactions including anaphylactic shock). It is possible to reduce the effectiveness of adrenaline used then. Special care should be taken when using the preparation in patients with atopic dermatitis and in people prone to allergic reactions.
If you are planning any surgery requiring anesthesia, please inform your doctor that you are using a beta blocker. It may be necessary to gradually discontinue use (the decision will be made by a physician).
In patients with glaucoma, regular monitoring of intraocular pressure and assessment of the cornea is recommended.
Use with caution in patients with myasthenia gravis (a disease characterized by muscle fatigue). Drugs from the beta-blocker group may exacerbate muscular weakness, typical of myasthenia gravis (double vision, eyelid drooping, general weakness).
Additional information about the other ingredients of the preparation:
the preparation contains benzalkonium chloride as a preservative, which can accumulate in contact lenses and destroy them (cause discoloration); people who use contact lenses should remove them before instillation and wait at least 15 minutes before re-inserting.

Does this preparation affect the ability to drive vehicles?
Caution should be exercised because, when administered to the eye, transient visual disturbances may occur which may impair the ability to drive vehicles and operate machinery / equipment.If visual disturbances occur, do not drive or operate mechanical devices until the disorder is resolved and acute vision returns.

Dosage of Arteoptic

The preparation is in the form of eye drops. Use the product as directed by your doctor. If you have any doubts regarding the use of the preparation, consult a physician.
Adults:
Usually, 1 drop 2 times daily into the conjunctival sac.
Elderly patients do not need to adjust their dosage.
Children:
There are no data on the safety and efficacy of the preparation in children.
Do not touch the surface of the eye or eyelid or any other surface with the dropper tip, as this may cause contamination of the preparation.
The preparation should be instilled into the conjunctival sac. After instillation, it is recommended to close the eyelid and compress the nasopharyngeal canal for approximately 2 minutes to reduce systemic absorption of the drug and to prevent systemic side effects.
If the intraocular pressure does not decrease sufficiently, your doctor will recommend combination therapy.
If other preparations administered to the eyes are used in parallel, wait at least 5 minutes between administrations of the next drugs.

Can I use Arteoptic during pregnancy and breastfeeding?

During pregnancy, do not use any medicine without consulting your doctor!
It is very important that before using any medicine during pregnancy or breastfeeding, consult a physician and explain beyond any doubt the potential risks and benefits associated with the use of the drug. If you are pregnant or plan to become pregnant, please inform the doctor prescribing the prescription for this medicine.
The preparation should not be used during pregnancy unless the doctor considers it absolutely necessary and in his opinion the expected benefits outweigh the possible risks. Only a doctor can assess the benefit / risk ratio in your case.
Before using the preparation during breastfeeding, consult a doctor.

Can I use other preparations in parallel?

Tell your doctor about all medicines you have recently taken, including those that are over the counter.
Caution should be exercised if the preparation is used in parallel with the following drugs (generally administered), due to the risk of increased action leading to a reduction in heart rate (bradycardia) and marked hypotension:
· Beta-blockers (another name: beta-blockers)
· Calcium channel antagonists (another name: calcium antagonists)
· Anti-arrhythmic drugs, including Amiodarone
· Digitalis glycosides
· parasympathomimetics
Antihypertensives, such as, for example, reserpine, clonidine, methyldopa, guanethidine, guanfacine.
In the case of topical use of other ophthalmic preparations, a minimum of 5 minutes should be allowed between each administration of the medicines.
Administration of karteolol at the same time as adrenaline may cause the pupil dilation.
The use of two locally active beta-blockers is not recommended.

What side effects can occur?

Like all medicines, Arteoptic can cause side effects, although they will not occur in all patients who use this medicine. Remember that the expected benefits of using the drug are usually greater than the damage resulting from the occurrence of side effects.
Beta-blockers applied topically to the conjunctival sac can be absorbed and cause systemic side effects that are characteristic of this group of drugs. The incidence of systemic adverse reactions after topical application to the eye is lower than after the general administration. However, the following side effects can not be ruled out: hypoglycaemia, insomnia, depression, sleep disorders, memory impairment, worsening of myasthenia gravis (including eyelid sagging), paresthesia, headache and / or dizziness, syncope, stroke / ischemia of the brain, visual disturbances, choroidal detachment, eye irritation (eg burning, pruritus, tearing, redness), feeling of a foreign body in the eye, dry eye, photosensitization (photophobia), conjunctivitis, blepharitis, keratitis, decreased corneal sensitivity, eyelid drooping, conjunctival hyperemia, double vision,reduction of atrioventricular conduction velocity, reduction of heart rate (bradycardia), atrioventricular block, heart failure, cardiac arrest, hypotension, worsening of peripheral circulatory disorders (severity of Raynaud's syndrome, severity of intermittent claudication), bronchospasm in patients with bronchial asthma or obstructive airways disease, shortness of breath, cough, nausea, vomiting, diarrhea, dry mouth, alopecia, exacerbation of psoriasis, muscle pain, sexual dysfunction (impotence), fatigue / weakness, hypersensitivity reactions (including angioneurotic edema , urticaria, rash, anaphylactic reactions).

Other preparations on the Polish market containing karteolol (karteolol hydrochloride)

Carteol LP 2% (eye drops)