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► Argosulfan (sulfatiazole (silver sulfatiazole salt)) - Practical Medicine

Argosulfan (sulfatiazole (silver sulfatiazole salt)) - cream

The name of the preparation Character; dose; package Manufacturer Price 100% Price after refund In which pharmacy?
Argosulfan cream; 20 mg / g; 40 g PharmaSwiss / Valeant 34.99 Check
Argosulfan cream; 20 mg / g; 400 g PharmaSwiss / Valeant 235.23 Check

Note: reimbursed drug prices are in line with the regulations in force from July 1, 2018.

The preparation contains the substance:sulfatiazole (silver sulfatiazole)

The drug is available on prescription

What is Argosulfan?

An antibacterial drug from the group of sulfonamides, applied topically to the skin to treat bacterial infections.

What does Argosulfan contain and how does it work?

The active substance of the preparation is silver sulfatiazole, a chemotherapeutic agent of the antimicrobial group of sulfonamides. Thanks to the combination of silver and sulfonamide, it exerts a much stronger antibacterial effect than the sulfatiazole itself. Sulfonamides have a bacteriostatic effect by blocking the activity of the bacterial enzyme involved in the synthesis of dihydrofolic acid necessary for bacterial growth. Silver sulfatiazole also has antiviral activity (against herpes, varicella and herpes viruses). The product is intended for topical use. Silver sulfatiazole salt is characterized by poor solubility and high stability. Thanks to this, it ensures that the proper concentration of the drug remains in the selected area for a long time and is practically not absorbed into the blood (absorption may increase if the preparation used on a large wound surface).

When to use Argosulfan?

The preparation is indicated for the local treatment of infections in the case of:
· Skin burns of all grades, also radiation
· bedsores
· Chronic leg ulcers.

When not to use this preparation?

Unfortunately, even if there are indications to use the preparation, it can not always be used. You can not use the preparation if you are allergic (you are hypersensitive) to any of the ingredients or other sulfonamides.
Contraindication to the use of the preparation is a congenital deficiency of the glucose-6-phorate dehydrogenase enzyme due to the risk of haemolytic anemia.
Do not use the preparation in premature babies, newborns and infants up to the age of 2 months (risk of developing jaundice in the cerebral cortices).
It should not be used in women who are breast-feeding.

Take special care with Argosulfan?

Certain diseases and other circumstances may constitute a contraindication to use or indication to change the dosage of the preparation. In some situations it may be necessary to carry out specific check-ups.
The preparation is intended only for use on the skin. Protect eyes from contact with the preparation.
Due to the risk of cross-allergy, the preparation should be used with caution in people with hypersensitivity to sulphonylurea (eg medicines used to treat diabetes), thiazides (eg hydrochlorothiazide with a diuretic effect), p-aminosalicylic acid (used to treat tuberculosis). If you are hypersensitive to any medication, in particular for medicines from the group of sulfonamides, consult your doctor before using the preparation.
Caution should be used if the product is used in shock, with extensive burn injuries or in people with burns that are difficult to reach.
Caution should be used when using the preparation in people with liver or kidney problems.In these patients, there is a risk of drug accumulation and side effects. If the preparation is used for a long time or on a large area of ​​the skin, it is recommended to control the concentration of sulfonamide in the blood, especially in people with impaired renal or hepatic function.
During the period of application, there is a risk of agranulocytosis or anemia. For this reason, your doctor may recommend regular monitoring of liver function, kidneys and blood counts.
Long-term use of the preparation should be avoided. Prolonged use may result in excessive development of resistant bacteria and fungi.
Do not use the product in parallel with other topical preparations on the same skin surface.
Information on additional ingredients of the preparation.
the preparation contains cetylstearyl alcohol, which may cause local allergic reactions (eg contact dermatitis)
the preparation contains propyl parahydroxybenzoate and methyl parahydroxybenzoate, which may cause allergic reactions (possible late-type allergic reactions).

Does this preparation affect the ability to drive vehicles?
The preparation has no influence on the ability to drive and use machines / machines.

Dosage of Argosulfan

The product is a cream and is intended for topical application to the skin. Use the product as directed by your doctor. If you have any doubts regarding the use of the preparation, consult a physician.
Adults and children after 2 months of age:
Burns: clean the burned wound cover under aseptic conditions with a layer of cream 2-3 mm thick; a dressing can be used (it is not necessary). The wound should be covered with cream throughout the treatment until the skin has healed or transplanted.
Decubitus ulcers, chronic leg ulcers: Apply a thin layer of cream 2-3 times a day to affected areas. If exudate occurs, before applying the cream again, wash the wound with, for example, a 3% aqueous boric acid solution or a 0.1% aqueous solution of chlorhexidine.
Caution should be used when using the preparation in people with liver or kidney problems. In patients with severe renal impairment, the concentration of sulfonamide in the blood serum should be monitored.
The use of the preparation is contraindicated in premature infants, newborns and infants up to the age of 2 months (risk of developing subcortical nuclei jaundice).

Can you use Argosulfan during pregnancy and breastfeeding?

During pregnancy, do not use any medicine without consulting your doctor!
It is very important that before using any medicine during pregnancy or breastfeeding, consult a physician and explain beyond any doubt the potential risks and benefits associated with the use of the drug. If you are pregnant or plan to become pregnant, please inform the doctor prescribing the prescription for this medicine.
Do not use the preparation in pregnant women. Use of the preparation during pregnancy is only allowed if the doctor considers it absolutely necessary, and in his opinion the benefits for the mother outweigh the risk to the fetus. Only a doctor can assess the benefit / risk ratio in your case.
Do not use during breast-feeding.

Can I use other preparations in parallel?

Tell your doctor about all medicines you have recently taken, including those that are over the counter.
The product is used topically. Folic acid or procaine and other agents used for local anesthesia from the group of PABA derivatives may reduce the antibacterial effect of the silver sulfathiazole salt. However, the occurrence of these interactions is unlikely.

What side effects can occur?

Like all medicines, Argosulfan can also cause side effects, although it will not occur in all patients who use this medicine. Remember that the expected benefits of using the drug are usually greater than the damage resulting from the occurrence of side effects.
Irritation and symptoms of hypersensitivity may occur at the application site (pruritus, burning, erythema). Long-term use may be associated with the occurrence of general adverse reactions of sulfonamides, including: kidney or liver damage, agranulocytosis, haemorrhagic diathesis, aplastic and hemolytic anemia, reduction of white blood cell count (leukopenia).Possible severe hypersensitivity reactions and skin reactions (Stevens and Johnson syndrome, exfoliative dermatitis).