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Note: reimbursed drug prices are in line with the regulations in force from July 1, 2018.
The preparation contains the substance:amlodipine
The drug is available on prescription
What is Amlozek?
A drug blocking Calcium
channels. It mainly works on blood vessels causing a reduction in muscle tone of the vascular walls and vasodilation. It lowers blood pressure and reduces peripheral vascular resistance.
What does Amlozek contain and how does it work?
The active substance is Amlodipine
, a dihydropyridine derivative belonging to a group of medicines called calcium channel blockers (or calcium channel blockers). Calcium antagonists act by blocking calcium channels, structures that allow the passage of calcium ions across the cell membrane. Amlodipine blocks the inflow of calcium ions from the extracellular space into the smooth muscle cells of the walls of the blood vessels and to a lesser extent into the cells of the heart muscle. Increasing the intracellular calcium concentration is necessary for the contraction of muscle cells. Amlodipine works mainly on peripheral blood vessels. Blockage of calcium channels reduces the tension of the vessel walls and vasodilation. The immediate effect of this action of amlodipine is lowering blood pressure. Enlargement of peripheral arterioles reduces peripheral vascular resistance, which relieves the heart (it reduces energy consumption by the myocardium and its oxygen demand). Coronary arteries are also likely to expand, which increases oxygen transport to the myocardium, also in patients with vasospastic angina (Prinzmetal). As a result, in patients with angina pectoris, exercise tolerance increases (the time to angina pain increases during exercise) and the incidence and severity of angina pains decreases. The clinical condition of patients with angina pectoris improves and Nitroglycerin
Preparations from this group are used as medicines to lower blood pressure and to relieve symptoms of angina. In hypertensive patients, taking once daily provides a clinically significant reduction in blood pressure, both standing and lying, for 24 hours. The effect of amlodipine appears gradually, so it does not cause sudden hypotension. To obtain a stationary concentration of amlodipine in the blood requires 7.-8.days of daily use.
When should Amlozek be used?
The preparation is indicated as monotherapy or in combination treatment:
· Stable angina
· Vasospastic angina (Prinzmetal).
When not to use this preparation?
Unfortunately, even if there are indications to use the preparation, it can not always be used. You can not use the preparation if you are allergic (you are hypersensitive) to any of the ingredients of the preparation or to dihydropyridine derivatives.
The preparation should not be used during pregnancy unless it is absolutely necessary in the opinion of the doctor. The preparation is contraindicated during breast-feeding.
When should you take extra care with Amlozek?
Certain diseases and other circumstances may constitute a contraindication to use or indication to change the dosage of the preparation. In some situations it may be necessary to carry out specific check-ups.
Caution should be exercised in patients with heart failure
, especially severe (NYHA grade III and IV); in this group of patients, there is an increased risk of pulmonary edema during the period of application.
People with hepatic impairment should be treated with caution as the effect of the preparation may be exacerbated. The doctor will start treatment with the use of small doses, which will be increased gradually while maintaining adequate control of the patient's condition.
Does this preparation affect the ability to drive vehicles?
The effect of the preparation on the ability to drive vehicles and operate equipment / machines is unlikely. The preparation may, in some people, cause side effects (eg headaches, dizziness, fatigue, visual disturbances and other symptoms) that may impair psychophysical fitness and the ability to react quickly.
Dosage of Amlozek
The preparation is in the form of tablets. It is intended for oral use. Do not exceed the recommended doses because it will not increase the effectiveness of the drug and may harm your health and life. If you have any doubts regarding the use of the preparation, consult a physician.
The usual recommended starting dose is 5 mg once daily. Then, depending on the response to your treatment, your doctor may increase the dose up to a maximum dose of 10 mg a day. The doctor will determine whether the preparation is to be used in monotherapy or in combination with other antihypertensive or anti-anginal drugs.
Elderly patients do not need to adjust their dosage. Caution should be exercised when increasing the dose.
In people with hepatic impairment, the effect of the preparation may be increased; caution should be used and treatment should be started with the lowest possible dose.
There is no need to adjust the dose in patients with impaired renal function. Amlodipine is not removed during dialysis.
It is not recommended for use in children due to the lack of data on the safety and efficacy of its use in this age group.
Can I use Amlozek during pregnancy and breastfeeding?
During pregnancy, do not use any medicine without consulting your doctor!
It is very important that before using any medicine during pregnancy or breastfeeding, consult a physician and explain beyond any doubt the potential risks and benefits associated with the use of the drug. If you are pregnant or plan to become pregnant, please inform the doctor prescribing the prescription for this medicine.
Use of the preparation in pregnancy is only allowed if the doctor deems it absolutely necessary and a safer alternative medicine can not be used and when the doctor believes that the benefits associated with the treatment clearly outweigh the risks associated with the use of the preparation.
The use of the preparation during breast-feeding is contraindicated.
Can I use other preparations in parallel?
Tell your doctor about all medicines you have recently taken, including those that are over the counter.
The preparation, if prescribed by a doctor, may be used in parallel with thiazide diuretics, beta-blockers, angiotensin converting enzyme inhibitors, prolonged nitrates, sublingual nitroglycerine, non-steroidal anti-inflammatory drugs, antibiotics, oral antidiabetic agents.
Cimetidine, antacids containing aluminum or Magnesium
do not affect the pharmacokinetics of amlodipine.
Amlodipine does not affect the pharmacokinetics of Atorvastatin
Parallel consumption of grapefruit juice is not recommended, because grapefruit juice may affect the effect of amlodipine and may increase blood pressure in some people.
Preparations that reduce the activity of cytochrome P450 3A4 isoenzyme, such as, for example, diltiazem, Verapamil
, azole antifungals (ketoconazole, Itraconazole
), protease inhibitors (ritonavir), macrolide antibiotics (erythromycin, Clarithromycin
) can inhibit the metabolism of amlodipine and increase its concentration in the blood and intensifying its operation. Caution should be exercised, especially in the elderly.
Preparations that increase the activity of the cytochrome P450 3A4 isoenzyme (such as, for example, rifampicin, St. John's wort, phenobarbital, phenytoin and carbamazepine) may reduce amlodipine levels in the blood and reduce its effect. Be careful.
Due to the aggregation of the antihypertensive effect of various preparations, amlodipine may potentiate the effect of parallel antihypertensive agents (such as beta-blockers, angiotensin-converting enzyme inhibitors, alpha-blockers, diuretics).
What side effects can occur?
Like all medicines, Amlozek may cause side effects, although they will not occur in all patients who use this medicine. Remember that the expected benefits of using the drug are usually greater than the damage resulting from the occurrence of side effects.
Common side effects include headache, dizziness, drowsiness, fatigue, swelling, palpitations, flushing and hot flushes, nausea, abdominal pain. Uncommonly possible: malaise, weakness, fainting, chest pain, tingling or numbness (paresthesia), tremors, sleep disturbances, mood changes, taste disturbances, irritability, blurred vision, tinnitus, gingival hyperplasia, dry mouth , intestinal motility disorders, vomiting, diarrhea, constipation, indigestion, alopecia, profuse sweating, rash, pruritus, urticaria, skin discoloration, purpura, hypotension, dyspnoea, rhinitis, muscular pains and spasms, joint pain, back pain , impaired urination, impotence, gynecomastia, increase / decrease of body weight. Very rare: gastritis, pancreatitis, increased activity of liver enzymes, jaundice, hepatitis, cough, vasculitis, angioneurotic edema
(swelling of the face, lips, tongue, throat, larynx in sporadic cases that may cause narrowing of the air passages, impede breathing and threaten life), severe skin reactions (erythema multiforme), urticaria, allergic reactions, increased blood Glucose
, thrombocytopenia, decreased white blood cell count (leukopenia), peripheral neuropathy.
Other preparations on the Polish market containing amlodipine
Agen 5 (tablets)
Agen 10 (tablets)
Aldan 5 (tablets)
Aldan 10 (tablets)
Amlodipine Aurobindo (tablets)
Amlodipine Bluefish (tablets)
Amlodipinum 123ratio (tablets)
Amlopin 5 (tablets)
Amlopin 10 (tablets)
Apo-Amlo 5 (tablets)
Apo-Amlo 10 (tablets)