|The name of the preparation||Character; dose; package||Manufacturer||Price 100%||Price after refund||In which pharmacy?|
|Ambrohexal||solution for injection; 7.5 mg / ml (15 mg / 2 ml); 5 amps 2 ml||Sandoz||10.73||Check|
Note: reimbursed drug prices are in line with the regulations in force from July 1, 2018.
Mucolytic drug, thins secretions in the airways and facilitates its removal.
The active substance of the preparation is Ambroxol . Ambroxol increases the secretion of mucus in the airways, reduces its viscosity and thins out the obstructing secretion. It improves the function of respiratory epithelial cilia which improves the transport of secretions. In this way, it supports the purification of the airways, facilitates expectoration and does not disturb the natural cough reflex.
Ambroxol crosses the blood-brain barrier, the placental barrier and into breast milk. Metabolized mainly in the liver. In severe renal impairment, accumulation of ambroxol metabolites is possible.
Indications for use of the preparation include:
• secretolytic treatment in acute and chronic bronchial and lung diseases associated with mucus secretion and transport disorders (such as: exacerbation of chronic bronchitis, bronchitis, bronchitis and bronchial asthma) when oral ambroxol administration is not possible;
• support for the production of pulmonary surfactant in premature infants and newborns with respiratory distress syndrome;
• prophylaxis to reduce the risk of atelectasis in patients with chronic obstructive pulmonary disease during intensive care after surgery.
Unfortunately, even if there are indications to use the preparation, it can not always be used. You can not use the product if you are allergic (you are hypersensitive) to any of the ingredients.
It is not recommended during the first trimester of pregnancy or during breastfeeding.
Certain diseases and other circumstances may constitute a contraindication to use or indication to change the dosage of the preparation. In some situations it may be necessary to carry out specific check-ups.
In children under 2 years of age, the preparation may be used only under the supervision of a physician.
Very rarely, too rapid intravenous administration of the preparation may cause headache, fatigue, exhaustion and heaviness in the legs.
Due to the risk of secretion, care should be taken if respiratory disorders, increased secretion, impaired cough reflex or ciliary clearing disorders occur.
Caution should be exercised in patients with impaired renal function or severe liver disease. In patients with renal insufficiency, it may be necessary to adjust the dosage by the doctor. In the case of severe renal failure, accumulation of ambroxol metabolites in the liver may occur.
Occasionally, the use of the preparation may be associated with severe skin lesions: Stevens and Johnson syndrome, erythema multiforme, toxic epidermal necrolysis and acute generalized pustular rash. These conditions can be a direct threat to life.If any changes occur within the skin or mucous membranes, it is necessary to immediately consult a physician and immediately prevent the cessation of the use of the preparation.
Does this preparation affect the ability to drive vehicles?
So far, the effects of the preparation on the ability to drive vehicles and operate equipment / machines have not been found.
The preparation is a solution for intravenous administration. The preparation may only be administered by qualified medical personnel. If you have any doubts about the use of the preparation, consult your doctor.
Secretolytic treatment in acute and chronic diseases of the bronchi and lungs:
Adults: 15 mg 2-3 times a day; in severe cases 30 mg 2-3 times a day.
Children: the average daily dose is 1.2-1.6 mg / kg body weight per day (up to 2 years of age 7.5 mg twice daily, 2-5 years 7.5 mg 3 times daily) after 5 years of age 15 mg 2-3 times a day).
The doctor will determine the duration of treatment.
Supporting the production of pulmonary surfactant in premature infants and newborns with respiratory distress syndrome:
The best results were obtained by using the drug at a dose of 30 mg / kg body weight per day in 4 divided doses. The drug should be given as a slow intravenous infusion lasting at least 5 minutes. Apply for 5 days.
Prophylaxis to reduce the risk of atelectasis:
Adults: 1 g once a day; drug is given 3 days before surgery, on the day of surgery and 2 days after it. The drug should be given as a slow intravenous infusion lasting at least 3-4 hours.
During pregnancy, do not use any medicine without consulting your doctor!
It is very important that before using any medicine during pregnancy or breastfeeding, consult a physician and explain beyond any doubt the potential risks and benefits associated with the use of the drug. If you are pregnant or planning to become pregnant, please inform your prescribing physician about this medicine.
It is not recommended during the first trimester of pregnancy. Use during the remainder of pregnancy only if the doctor deems it absolutely necessary. Be careful.
It is not recommended to use the product during breastfeeding.
Tell your doctor about all medicines you have recently taken, including those that are over the counter
You should not take medicines that inhibit the cough reflex (anti-tussive medicines, such as codeine), because this reflex promotes the removal of large secretion after liquefaction. Decreasing the cough reflex may cause secretion.
Like all medicines, AmbroHEXAL can also cause side effects, although they will not occur in all patients who use this medicine. Remember that the expected benefits of using the drug are usually greater than the damage resulting from the occurrence of side effects.
Uncommon: dry mouth and respiratory tract, increased salivation, watery runny nose, constipation, difficulty urinating, erythema, elevated temperature. Rare: hypersensitivity reactions, rash, urticaria. Possible other side effects for which their incidence has not been determined: nausea, vomiting, indigestion, diarrhea, abdominal pain, Anaphylactic reactions (severe reactions that may be life threatening, including throat edema, larynx, bronchospasm, dyspnea, hypotension, shock) , severe skin reactions (Stevens and Johnson syndrome, melanotic toxic necrosis, erythema multiforme, acute generalized pustular rash).
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