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► Alphagan (Brymonidyna) - Medycyna Praktyczna

Alphagan (brimonidine) - eye drops, solution

The name of the preparation Character; dose; package Manufacturer Price 100% Price after refund In which pharmacy?
Alphagan eye drops, solution; 2 mg / ml; 5 ml Allergan 29.84 0.00
3.20
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Note: reimbursed drug prices are in line with the regulations in force from July 1, 2018.

The preparation contains the substance:brimonidine

The drug is available on prescription

What is Alphagan?

A medicine from the sympathomimetic group applied topically to the eye (into the conjunctival sac) to reduce intraocular pressure.

What does Alphagan contain and how does it work?

The active substance is brimonidine, a drug from the sympathomimetic group. Sympathomimetics work by stimulating a specific type of receptors, the so-called adrenergic receptors on the surface of target cells. These are receptors stimulated in physiological conditions by adrenaline or noradrenaline released after the activation of the sympathetic nervous system. Brimonidine is selective for alpha-2 adrenergic receptors, which means that it does not affect alpha-1 receptors at the doses used. Thanks to the selective action, it does not dilate the pupil. It lowers intraocular pressure both by reducing the production of aqueous humor and by increasing its outflow. In the form of eye drops, brimonidine is applied to the conjunctival sac. It exerts a local action, is also absorbed into the systemic circulation and may cause systemic side effects. It affects the functioning of the cardiovascular and respiratory systems to a minimum.
The preparation is characterized by a rapid onset of action. The maximum effect occurs after 2 hours after topical application to the eye. The drug is mainly excreted through the kidneys. Brimonidine is used as monotherapy or in combination with beta-blockers or prostaglandin analogs.

When to use Alphagan?

The preparation is indicated to lower the increased intraocular pressure in patients with open-angle glaucoma or ocular hypertension.
The preparation can be used:
· As monotherapy in patients in whom the use of topical beta-blockers (another name is beta-blockers) is contraindicated
· As adjunctive therapy in combination with other drugs that lower the intraocular pressure, when lowering the pressure with just one drug is insufficient.

When not to use this preparation?

Unfortunately, even if there are indications to use the preparation, it can not always be used. You can not use the preparation if you are allergic (you are hypersensitive) to any of the ingredients.
You can not use the preparation if you are taking:
· Drugs from the group of MAO inhibitors
· Antidepressants that affect noradrenergic transmission (eg tricyclic antidepressants, mianserin).
Contraindication is contraindicated in newborns, infants and children up to the age of 2.
Do not use the product during breast-feeding.

When should you take extra care with Alphagan?

Certain diseases and other circumstances may constitute a contraindication to use or indication to change the dosage of the preparation.In some situations it may be necessary to carry out specific check-ups.
The preparation is intended only for external application, locally to the conjunctival sac.
When using the preparation in children 2.-7. year of life and / or with a body weight of less than 20 kg, caution should be exercised and the child should be observed; use of the preparation in this age group is associated with a high incidence of drowsiness of high severity.
Use with caution in patients with severe or unstable and non-responsive coronary artery disease.
During treatment, local side effects of allergic nature may occur. In the event of their occurrence, a doctor should be consulted who will decide if it is necessary to discontinue use.
The use of the preparation may cause delayed hypersensitivity reactions.
Use with caution in patients:
· With depression
· With cerebral or coronary circulation insufficiency
· With Raynaud's syndrome
· With orthostatic hypotension
· With thromboangiitis obliterans.
There are no data on the safety and efficacy of the preparation in patients with impaired renal or hepatic function; Caution should be exercised if the preparation is used in these groups of patients.
Additional information about the other ingredients of the preparation:
the preparation contains benzalkonium chloride as a preservative, which can accumulate in contact lenses and destroy them (cause discoloration); people who use contact lenses should remove them before instillation and wait at least 15 minutes before re-inserting.

Does this preparation affect the ability to drive vehicles?
The use of the preparation may cause fatigue and / or drowsiness and blurred vision (including blurred vision) which may impair the ability to drive vehicles and operate machinery / equipment. Until these symptoms disappear, do not drive or operate machines / machines.

Dosage of Alphagan

The preparation is in the form of eye drops. Use the product as directed by your doctor. Do not exceed the recommended doses because it will not increase the effectiveness of the drug and may harm your health and life. If you have any doubts regarding the use of the preparation, consult a physician.
Adults: 1 drop 2 times daily (approximately every 12 hours) to the conjunctival sac.
To limit the systemic absorption of the active substance, it is recommended to compress in the medial angle of the eye (near the nose) for 1 minute, immediately after instillation.
If other preparations administered to the eyes are used in parallel, wait 5-15 minutes between administrations of the next drugs.
There are no data on the safety and efficacy of the preparation in patients with impaired renal or hepatic function; Caution should be exercised if the preparation is used in these groups of patients.
There are no data on the safety and efficacy of the preparation in children and adolescents (12 -17 years of age). Use in newborns, infants and children up to the age of 2 is contraindicated, and in children up to 12 years of age is not recommended.
Wash your hands before using the product. Do not touch the surface of the eye or the eyelid or any other surface with the dropper tip, as this may contaminate the product and lead to eye infection. The infection can cause serious eye damage or blindness.

Can Alphagan be used during pregnancy and breastfeeding?

During pregnancy, do not use any medicine without consulting your doctor!
It is very important that before using any medicine during pregnancy or breastfeeding, consult a physician and explain beyond any doubt the potential risks and benefits associated with the use of the drug. If you are pregnant or plan to become pregnant, please inform the doctor prescribing the prescription for this medicine.
Use during pregnancy is only allowed if the doctor considers it absolutely necessary, and in his opinion the expected benefits outweigh the possible risks. Only a doctor can assess the benefit / risk ratio in your case.
Do not use the product during breast-feeding.

Can I use other preparations in parallel?

Tell your doctor about all medicines you have recently taken, including those that are over the counter.
The use of the preparation is contraindicated if you are taking medicines from the MAO group or antidepressants that affect noradrenergic transmission (eg tricyclic antidepressants, mianserin).
There have been no detailed studies of drug interactions with other drugs, however, the possibility of adding up and acting together should be considered if the preparation is used in parallel with central nervous system depressants such as, for example, opioid analgesics, sedatives and hypnotics ( including barbiturates), anesthetics and also if alcohol is consumed during the use of the preparation.
Caution should be exercised if drugs that may affect catecholamine concentrations (eg, chlorpromazine, methylphenidate, reserpine) are used in parallel.
The preparation may cause a clinically insignificant reduction in blood pressure; caution should be used if blood pressure lowering drugs and / or cardiac glycosides are used.
Caution should be used if the product is used in parallel with agents that stimulate or block adrenergic receptors, such as, for example, isoprenaline, prazosin, which may interact with alpha-agonists or alter their activity.

What side effects can occur?

Like all medicines, Alphagan can also cause side effects, although they will not occur in all patients who use this medicine. Remember that the expected benefits of using the drug are usually greater than the damage resulting from the occurrence of side effects.
There may be local side effects on the eye / eyes: eye irritation (stinging, stinging, hyperemia, pruritus, foreign body sensation, conjunctival blebs), blurred vision, allergic blepharitis, allergic conjunctivitis, local allergic reactions, swelling and eyelid hyperemia, blepharitis, eye edema, conjunctivitis, eye pain, tearing, photophobia, Corn eal epithelium damage, dry eyes, conjunctivitis, blurred vision, conjunctivitis, iritis, pupil constriction, iritis and ciliary inflammation, eyelid pruritus .
In addition, systemic side effects may occur such as: headache and dizziness, drowsiness, disturbed taste, dry mouth and nasal passages, palpitations and arrhythmias, reduction / increase in heart rate, upper respiratory tract symptoms, dyspnea, elevation or lowering of blood pressure, gastrointestinal disturbances, fainting, fatigue, weakness, insomnia, depression, generalized hypersensitivity reactions, erythema, face edema, rash, pruritus.

Other preparations on the Polish market containing brimonidine

Biprolast (eye drops, solution)
Briglau PPH (eye drops, solution)
Brymont (eye drops, solution)
Luxfen (eye drops, solution)
Mirvaso (gel)
Oculobrim (eye drops, solution)