► Alka-Prim (acetylsalicylic acid) - Practical Medicine

Alka-Prim (acetylsalicylic acid) - effervescent tablets

The name of the preparation Character; dose; package Manufacturer Price 100% Price after refund In which pharmacy?
Alka-Prim effervescent tablets; 330 mg; 10 tables Polpharma 10.55 Check

Note: reimbursed drug prices are in line with the regulations in force from July 1, 2018.

The preparation contains the substance:acetylsalicylic acid

The drug is available without a prescription

What is Alka-Prim?

A non-steroidal anti-inflammatory drug with analgesic, antipyretic and anti-inflammatory effects and inhibits platelet aggregation.

What does Alka-Prim contain and how does it work?

The active substance is a non-steroidal anti-inflammatory drug (NSAID) Acetylsalicylic acid . Like many other NSAIDs , it has anti-inflammatory, analgesic, antipyretic and platelet aggregation inhibitors. The basis of the mechanism of action of acetylsalicylic acid is the inhibition of cyclooxygenases (both COX-1 and COX-2), enzymes involved in the synthesis of prostaglandins and thromboxane from lipids of cell membranes. Prostaglandins play a significant role in the development of inflammation, and thromboxane stimulates platelet aggregation and vasoconstriction (which may contribute to the formation of clots and congestion). Inhibition of increased prostaglandin synthesis underlies the analgesic and anti-inflammatory effects of acetylsalicylic acid, and the inhibition of thromboxane synthesis at the base of its antiaggregatory action.
Acetylsalicylic acid, used in low doses (usually 75-150 mg daily), inhibits platelet COX-1 activity. This leads to inhibition of thromboxane synthesis, reduction of platelet aggregation abilities and inhibition of vasodilator-dependent vasoconstriction. COX-1 activity is inhibited by acetylsalicylic acid irreversibly and persists throughout the life of the platelet, i.e. about 9 days. Analgesic and anti-inflammatory effects, dependent on inhibition of COX-2 induced inflammation, require higher doses of acetylsalicylic acid (usually 2-6 g per day).
The rate of absorption of acetylsalicylic acid from the gastrointestinal tract depends on the pharmaceutical form used. The form of suspension (dissolved effervescent tablets) accelerates the absorption of the active substance. Glycine contained in the preparation reduces the irritating effect of acetylsalicylic acid on the mucous membrane of the stomach. Analgesic and antipyretic effects of the preparation start after 30 minutes from the moment of application, reaching the maximum after 1-3 hours. After a single dose, the analgesic effect lasts for 3-6 hours.

When to use Alka-Prim?

The preparation is indicated:
in low to moderate pain (eg: headache, muscle and joint pain)
antipyretics in the course of colds, viral infections and other diseases.

When not to use this preparation?

Unfortunately, even if there are indications to use the preparation, it can not always be used. You can not use the preparation if you are allergic (you are hypersensitive) to any of the ingredients of the preparation or to other salicylates.
It is contraindicated if you have ever had asthma attacks (so-called Aspirin asthma), bronchospasm, rhinitis, shock, urticaria or other signs of hypersensitivity after taking salicylates or non-steroidal anti-inflammatory drugs (eg Ibuprofen , Ketoprofen , Naproxen ).
The use of the preparation is contraindicated in people:
patients with bronchial asthma, chronic respiratory disease, allergic or seasonal rhinitis or nasal edema (increased risk of asthma attack, angioneurotic edema or urticaria after taking non-steroidal anti-inflammatory drugs)
with active or recurrent gastric and / or duodenal ulcer disease, inflammation or Gastrointestinal bleeding (risk of ulcer recurrence and gastrointestinal haemorrhage)
with severe liver or kidney failure
with severe heart failure
with increased risk of bleeding (haemorrhagic diathesis, haemophilia, thrombocytopenia, any blood coagulation disorders) or using anticoagulants (eg Warfarin , Heparin ) in parallel
deficiency of Glucose -6-phosphate dehydrogenase
using Methotrexate in doses of 15 mg in a week or more in parallel
· In women in the third trimester of pregnancy
· In women who are breast-feeding
· In children up to 12 years of age in the course of viral infections, especially influenza or chickenpox, due to the risk of Reye's syndrome, a serious condition leading to liver and brain damage that may be life-threatening.

Take special care with Alka-Prim?

Certain diseases and other circumstances may constitute a contraindication to use or indication to change the dosage of the preparation. In some situations it may be necessary to carry out specific check-ups.
Use of the product at the lowest effective dose over the shortest possible period reduces the risk of side effects.
Patients taking other medicines in parallel should consult a physician before using the product, as dosage may need to be changed or discontinuation of a specific preparation (see paragraph "Can I use other medicines in parallel?"). In particular, the use is not recommended if the anti-diabetic medication of the sulphonylurea group (the risk of hypoglycaemia) or medicines used to treat gout are used in parallel.
Caution should be exercised if the preparation is used:
in people with impaired renal function (increased risk of side effects and worsening of renal function)
in patients with juvenile rheumatoid arthritis and / or systemic lupus erythematosus and liver failure (increased salicylate toxicity, liver function should be monitored).
The preparation may cause prolongation of bleeding time, including during or after surgery (this also applies to minor surgical procedures, eg tooth extraction). The preparation should be discontinued 5-7 days before the planned surgery, after prior consultation with a doctor.
Caution should be exercised if the preparation is used in cases of genital tract haemorrhages, heavy menstrual bleeding (they may be worse), by women with intrauterine devices, and in people with hypertension or heart failure.
Alcohol should not be consumed while using the product because alcohol increases the risk of gastrointestinal adverse reactions (ulceration, bleeding).
Special care should be taken if the preparation is used by elderly people. In this age group, there is an increased risk of side effects, such as gastrointestinal bleeding or perforation, which can lead to death. If prolonged use is required, a doctor should be consulted, as it may be necessary to reduce the dose or to prolong the interval between doses. Patients in this age group should remain under medical supervision.
The use of non-steroidal anti-inflammatory drugs, including the preparation, may cause fertility disorders in women. This effect is transient and disappears after treatment.

Does this preparation affect the ability to drive vehicles?
There was no effect of the preparation on the ability to drive vehicles and operate equipment / machines.

Dosage of Alka-Prim

The preparation is in the form of effervescent tablets. Use the preparation as recommended. Do not exceed the recommended doses because it will not increase the effectiveness of the drug and may harm your health and life. If you have any doubts regarding the use of the preparation, consult a physician.
Adults: 1-2 effervescent tablets 2-4 times a day.Do not use more than 3g per day in adults.
Adolescents after 12 years: 2-3 effervescent tablets daily.
Do not use the doctor for more than 3 days without consulting a doctor.
Application method:
The preparation is intended for oral use. Effervescent tablets should be dissolved in 0.75 glasses of water and the suspension should be drunk. The preparation should be taken with a meal.

Can I use Alka-Prim during pregnancy and breastfeeding?

During pregnancy, do not use any medicine without consulting your doctor!
It is very important that before using any medicine during pregnancy or breastfeeding, consult a physician and explain beyond any doubt the potential risks and benefits associated with the use of the drug. If you are pregnant or plan to become pregnant before using the preparation, consult a doctor (see the warnings in the section "When should you take extra care with the preparation?").
The use of the preparation is contraindicated in women in the third trimester of pregnancy. The use of acetylsalicylic acid in the first and second trimester of pregnancy, and in women planning pregnancy, is allowed only on the order of a doctor in cases when considering the ratio of expected benefits to the mother to possible risk to the fetus he considers the use of the preparation as strictly necessary (only short-term use of small doses). Only a doctor can assess the benefit / risk ratio in your case.
The preparation is contraindicated in breastfeeding women.

Can I use other preparations in parallel?

Tell your doctor about all medicines you have recently taken, including those that are over the counter.
Concomitant use of acetylsalicylic acid and methotrexate at doses of 15 mg per week or more is contra-indicated (possible increase in methotrexate concentration and increased bone marrow toxicity, sometimes severe intoxication leading to death).
If you are using any of the medicines listed below, consult your doctor before using the product because you may need to change your dosage or stop taking your medicine. Take particular care if you are using:
· Methotrexate at doses less than 15 mg per week (possible increase in methotrexate concentration and increased bone marrow toxicity, may be recommended by the doctor to periodically check blood counts)
· Anticoagulants such as warfarin, heparin (possible increase in anticoagulant effect and prolonged bleeding time, increased risk of haemorrhage)
· Selective serotonin reuptake inhibitors, e.g. citalopram , paroxetine, sertraline (increased risk of bleeding)
· Other non-steroidal anti-inflammatory drugs (parallel use of acetylsalicylic acid and other NSAIDs is not recommended because of the increased risk of side effects, especially gastrointestinal bleeding and kidney damage)
· Drugs that increase uric acid excretion in the urine, eg benzbromarone, probenecid (acetylsalicylic acid used together with drugs increasing the uric acid excretion, causes the weakening of the action of these drugs; with medicines used to treat gout)
· Cardiac glycosides, e.g. Digoxin (risk of intensification of digoxin)
· Antidiabetic agents, eg insulin , sulphonylureas eg tolbutamide, chlorpropamide, glibenclamide (their severity, risk of hypoglycaemia, should not be used in parallel with sulfonylureas)
· Thrombolytics, such as streptokinase and altepaza, and platelet aggregation inhibitors such as ticlopidine, Clopidogrel (possibly more potent, prolonged bleeding time and increased risk of haemorrhage)
· Diuretics, e.g. Furosemide (possible reduction of diuretic effectiveness, possible increase in furosemide toxicity on the hearing organ)
· Antihypertensive agents, including angiotensin converting enzyme inhibitors, angiotensin antagonists, and beta blockers (possible reduction of antihypertensive effect)
· Glucocorticosteroids generally used, with the exception of Hydrocortisone used as replacement therapy in Addison's disease (use with acetylsalicylic acid increases the risk of stomach ulcer and / or duodenum and gastrointestinal bleeding)
· Valproic acid (risk of increased toxicity and aggravation of antiaggregation)
· Acetazolamide (carbonic anhydrase inhibitor, a weak diuretic used sometimes in the treatment of e.g. glaucoma, risk of increased toxicity of acetazolamide).
Alcohol consumption increases the risk of gastrointestinal adverse reactions, including haemorrhage.

What side effects can occur?

Like all medicines, Alka-Prim can cause side effects, although they will not occur in all patients who use this medicine. Remember that the expected benefits of using the drug are usually greater than the damage resulting from the occurrence of side effects.
Gastrointestinal side effects may occur, including: nausea, vomiting, indigestion, abdominal pain, anorexia, gastroenteritis, gastrointestinal bleeding (including tarry stools, vomiting) and gastric ulcer and / or duodenum, sometimes with bleeding and perforation, increased liver enzymes, transient liver dysfunction, focal liver necrosis, tenderness and hepatomegaly, especially in patients with juvenile rheumatoid arthritis, systemic lupus erythematosus, rheumatic fever or pre-existing liver disease. Possible: headache and dizziness, tinnitus, impaired hearing, hypertension, heart failure, kidney problems, renal papillary necrosis, interstitial nephritis, proteinuria, red blood cells in the urine, prolonged bleeding time and increased risk of bleeding (perioperative hemorrhage, hematomas, nosebleeds, genital tract bleeding, bleeding from the gums, gastrointestinal haemorrhage, cerebral haemorrhage, especially in people with uncontrolled hypertension and / or taking haemostatic agents in parallel). In some cases, haemorrhage can be life-threatening; they can also lead to acute or chronic anemia (also as a result of latent microcortes from the gastrointestinal tract) with appropriate symptoms, such as weakness, paleness, and reduced blood supply to organs and tissues. Patients with glucose-6-phosphate dehydrogenase deficiency may experience haemolytic anemia. Possible other hematological disorders (agranulocytosis, leukopenia). Hypersensitivity reactions (rash, urticaria, pruritus) and Anaphylactic reactions may occur, including life threatening anaphylactic shock, angioneurotic edema (swelling of the face, larynx, tongue, throat that may impede breathing), bronchospasm, asthma attack and severe skin reactions.

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