Note: reimbursed drug prices are in line with the regulations in force from July 1, 2018.
The active substance is Paracetamol
. Paracetamol has analgesic and antipyretic effects. The mechanism of its action consists in inhibiting the activity of cyclooxygenase 2 (COX-2) in the brain and in the spinal cord, the enzyme responsible for the synthesis of prostaglandins. Paracetamol has no anti-inflammatory activity because it practically does not inhibit the activity of cyclooxygenases and prostaglandin synthesis in peripheral tissues. It does not damage the gastric mucosa. It does not inhibit platelet aggregation and does not affect the coagulation process. After oral administration, paracetamol is well and quickly absorbed from the gastrointestinal tract, mainly in the small intestine. It passes through the placenta and also into breast milk.
Unfortunately, even if there are indications to use the preparation, it can not always be used. You can not use the preparation if you are allergic (you are hypersensitive) to any of the ingredients.
The use of the preparation is contraindicated in people:
with severe liver failure
Certain diseases and other circumstances may constitute a contraindication to use or indication to change the dosage of the preparation. In some situations it may be necessary to carry out specific check-ups.
Other paracetamol-containing medicines should not be used in parallel because of the risk of overdose and serious side effects. Check whether other medicines used do not contain paracetamol.
Caution should be exercised in patients with impaired renal or hepatic function and in patients with bronchial asthma.
In people who are debilitated, starved, with liver failure or regularly consuming alcohol, there is an increased risk of liver damage.
Alcohol should not be consumed while using the product. Consumption of alcohol during the use of the preparation may lead to toxic liver damage and its inefficiency.
Does this preparation affect the ability to drive vehicles?
There was no effect on the ability to drive or use machines / machines.
The preparation is in the form of tablets for oral use. Use the preparation as recommended. Do not exceed the recommended doses because it will not increase the effectiveness of the drug and may harm your health and life. If you have any doubts regarding the use of the preparation, consult a physician.
0.3-1 g, no more frequently than every 4 hours; maximum 4g daily.
Children. 6.-12. age.
0.15-0.3 g 3-4 times a day.
The preparation should be used no more frequently than every 4 hours. In case of renal dysfunction, reduce the dose or extend the interval between doses to 6 hours.
Do not use the preparation for more than 10 days for the treatment of pain or for more than 3 days for the treatment of fever without consulting a doctor.
Tell your doctor about all medicines you have recently taken, including those that are over the counter. In particular, consult your doctor if you are using any of the medicines listed below, as you may need to change your dosage or stop taking your medicine.
It must not be used with other paracetamol medicines (risk of paracetamol overdose and serious side effects).
Do not use with MAO inhibitors
or within 2 weeks after discontinuing their use. Paracetamol used with MAO inhibitors may cause arousal and high fever.
Do not use with zidovudine. Paracetamol may increase the toxic effects of zidovudine (risk of neutropenia, risk of liver damage).
Paracetamol taken regularly may increase the effect of anticoagulants from the coumarin group (eg Warfarin
), increasing the risk of bleeding.
Caffeine enhances the analgesic effect of paracetamol.
Medicines increasing hepatic metabolism, including rifampicin, isoniazid, antiepileptics (eg phenytoin, carbamazepine), barbiturates (eg phenobarbital), hypnotics and alcohol, diflunisal, sulfinpyrazone used in parallel with paracetamol may lead to liver damage, even if recommended doses. If you use them, please consult your doctor.
The use of paracetamol with non-steroidal anti-inflammatory drugs (NSAIDs) in people with impaired renal function may cause further deterioration of their function and severity of failure.
Consumption of alcohol during the use of the preparation may lead to toxic liver damage and its inefficiency.
Like all medicines, Acenol and Acenol forte can cause side effects, although they will not occur in all patients who use this medicine. Remember that the expected benefits of using the drug are usually greater than the damage resulting from the occurrence of side effects.
The following may occur: haemolysis occurring sporadically in people with blood cell enzymopathy, deficiency of Glucose
-6-phosphate dehydrogenase (occurring mainly in populations of the Mediterranean and Black); hypothermia (body temperature below 35.5 ° C) (previously only found in children); impaired renal and / or liver function, liver damage (mainly in alcoholics or long-term use). Extremely rare: rash and hypersensitivity (only a few cases have been described) with typical symptoms of a startling shock. Isolated cases of hematological disorders, i.e. thrombocytopenia and agranulocytosis.