|The name of the preparation||Character; dose; package||Manufacturer||Price 100%||Price after refund||In which pharmacy?|
|Abaktal||coated tablets; 400 mg; 10 tables||Sandoz||39.76||Check|
Note: reimbursed drug prices are in line with the regulations in force from July 1, 2018.
An antibacterial drug generally used. A chemotherapeutic agent used to treat bacterial infections.
The active substance is pefloxacin. It is a synthetic chemotherapeutic agent, a substance with a broad spectrum of antibacterial activity. Due to its chemical structure, it belongs to a group of medicines called fluoroquinolones. The mechanism of action of pefloxacin is the inhibition of the bacterial enzyme activity necessary for the formation of the corr ect structure of the bacterial nucleic acid (DNA). Bacterial DNA is destabilized, which in turn leads to inhibition of divisions and the death of the bacterial cell. Pefloxacin has slightly less activity compared to Ciprofloxacin and Ofloxacin . After oral administration, it is absorbed very well and quickly from the gastrointestinal tract.
The preparation is indicated for the treatment of infections caused by pefloxacin susceptible organisms, such as:
• respiratory tract infection
• urinary tract infection
• infection of the ear, nose and throat
• infections of the digestive tract and bile ducts
• infection of bones and joints
• skin infection
• septicemia and endocarditis
Pefloxacin is also effective in the treatment and prevention of infections in immunocompromised patients.
Unfortunately, even if there are indications to use the preparation, it can not always be used. You can not use the preparation if you are allergic (you are hypersensitive) to any of the ingredients, wheat or other quinolones. You can not use the preparation if:
• you have a disease of the central nervous system, such as epilepsy or atherosclerosis of cerebral blood vessels
• the use of other medicines from the quinolone group has caused damage to the tendon in the past
• you have a deficiency of Glucose -6-phosphate dehydrogenase.
Do not use the preparation in children and adolescents up to 18 years of age.
The preparation is contraindicated in pregnant women and during breastfeeding.
Certain diseases and other circumstances may constitute a contraindication to use or indication to change the dosage of the preparation. In some situations it may be necessary to carry out specific check-ups.
The preparation may cause cutaneous hypersensitivity reactions to light. During the period of application and for at least 6 days after the end of treatment, exposure to sunlight or UV (solarium, quartz lamps) should be avoided. If any changes on the skin occur, please consult your doctor.
Excessive physical effort should be avoided during treatment.
The preparation, like other fluoroquinolones, increases the risk of inflammation and sometimes tendon rupture (cases of Achilles tendon rupture). This is particularly true for the elderly and people who use corticosteroid s in parallel. If painful swelling or inflammation of the tendons appears, avoid physical exercise and consult a physician.Your doctor may advise you to stop taking the medicine and continue treatment with another antibiotic.
For people withmyasthenia gravis be careful.
The use of the preparation may cause hypersensitivity reactions. If you suspect hypersensitivity reactions, please consult your doctor immediately. The doctor may recommend discontinuation of the preparation.
The use of the preparation may increase the risk of seizures or sensory and / or motor neuropathy in some people. If you experience seizures, significant psychiatric disorders or neuropathy symptoms, you should immediately consult a physician.
During the period of treatment, care should be taken to ensure adequate hydration and take a lot of fluids.
Elderly, with cerebrovascular disorders, changes in the structure of the brain or stroke, care should be taken.
In patients with porphyria, the use of the preparation may exacerbate the symptoms of the disease. If you have porphyria or suspect such a possibility, consult your doctor before using the product.
In the event of visual disturbances or other eye disorders, immediately consult an ophthalmologist.
In people with liver failure, it is necessary to adjust the dosage by the doctor. The preparation should be avoided in patients with severe hepatic impairment.
If diarrhea occurs during or after treatment, do not treat it yourself, but consult a physician. There is a risk of pseudomembranous colitis, sometimes with a serious, life-threatening course. Its clinical symptoms (such as watery stools with blood and mucus, blunt, spilled or colic stomach ache, fever, periodic pressure on the stool) are caused by the wormClostridium difficile, which can multiply in the conditions of disturbance of the normal bacterial flora in the gut. The use of drugs that inhibit intestinal motility is contraindicated in this case. If necessary, the doctor will apply appropriate pharmacological treatment.
Due to the risk of hypoglycaemia, it is recommended to control the level of sugar in people with diabetes using insulin or hypolipemic drugs and simultaneously treated with quinolones.
Avoid prolonged use of antibiotics, as this may lead to excessive growth of non-susceptible organisms.
There have been reports of prolongation of the QT interval when using other drugs in this group.
Additional information about the other ingredients of the preparation:
the preparation contains gluten, but in negligible amounts; it is considered safe for people with celiac disease;
the preparation contains lactose; people with galactose intolerance, lactase deficiency or malabsorption of glucose-galactose should not use this preparation.
Does this preparation affect the ability to drive vehicles?
In some people the preparation may impair the ability to drive vehicles and operate equipment / machines. This risk is further increased if alcohol is consumed in parallel.
The preparation is in the form of coated tablets. It is intended for oral use. Use the product as directed by your doctor. Do not exceed the recommended doses because it will not increase the effectiveness of the drug and may harm your health and life. If you have any doubts regarding the use of the preparation, consult a physician. The doctor will select the individual dose depending on the indication, the severity of the infection and the patient's liver function. In certain special patient groups, additional dosage adjustment is necessary.
Usually 400 mg 2 times a day are used every 12 hours.
In patients with impaired renal function, no dosage adjustment is necessary. Pefloxacin is not removed during dialysis and an additional dose should not be taken after dialysis.
In patients with impaired liver function, dosage adjustment by the physician is necessary. The preparation should be avoided in patients with severe hepatic impairment.
Method of administration:
To reduce the risk of gastrointestinal disturbances, the drug should be taken with a meal.
During pregnancy, do not use any medicine without consulting your doctor!
It is very important that before using any medicine during pregnancy or breastfeeding, consult a physician and explain beyond any doubt the potential risks and benefits associated with the use of the drug. If you are pregnant or plan to become pregnant, please inform the doctor prescribing the prescription for this medicine.
The preparation is contraindicated during pregnancy and breast-feeding.
Tell your doctor about all medicines you have recently taken, including those that are over the counter. In particular, inform your doctor if you use:
• iron and Magnesium salts, antacids containing aluminum, magnesium and aluminum didanosine preparations
• oral anticoagulants (eg Warfarin , acenocoumarol)
The parallel use of pefloxacin with aluminum-containing antacids containing aluminum, magnesium and iron salts, and combinations of dydaonosine with magnesium or aluminum, and with sucralfate reduces the absorption of oral pefloxacin. Therefore, the preparation should be used at least 2 hours before admission or 4 to 6 hours after taking these medicines. Pefloxacin may reduce the metabolism of theophylline in the liver and increase its concentration in serum. Quinolones may increase the effect of anticoagulants (eg warfarin); if you use these medicines in parallel, your doctor may recommend checking your blood clotting parameters. The use of corticosteroids in parallel (especially in people over 60 years old, with renal dysfunction or lipid dysfunction) is not recommended due to the risk of tendon side effects (inflammation or rupture of the Achilles tendon).
The preparation may affect the results of the urine concentration test (false positives).
Pefloxacin does not affect the determination of urinary glucose.
Like all medicines, Abaktal can also cause side effects, although it will not occur in all patients who use this medicine. Remember that the expected benefits of using the drug are usually greater than the damage resulting from the occurrence of side effects.
Adverse reactions that may occur after the use of the preparation include: nausea, vomiting, diarrhea, abdominal pain, indigestion, lack of appetite, taste disturbances, headache and dizziness, excessive agitation and restlessness, depression, sleep disorders (drowsiness, insomnia, nightmares) , confusion, hallucinations, tremors, convulsions, epileptic seizures, psychotic states, blurred vision. Rarely, intestinal inflammation may occur and very rarely pseudomembranous enteritis (manifested by severe persistent or bloody diarrhea during or after treatment), the course of which may be life-threatening. Possible increase in liver enzymes and increased bilirubin in the blood. The following may occur: hematological disorders (decrease in the number of leukocytes, thrombocytopenia, eosinophilia) and renal dysfunction (precipitation of crystals in the urine, haematuria , interstitial nephritis), muscle and joint pain, inflammation and rupture of the tendons (Achilles tendon). Possible hypersensitivity reactions to sunlight or UV radiation, as well as severe hypersensitivity reactions of the anaphylactic type: angioneurotic edema (swelling of the mouth, tongue, throat impeding breathing) and anaphylactic shock. Very rarely the separation of nails from the placenta.